To me: The Simpsons >>>>> The Flinstones >>>>> Tom and Jerry.
But I rarely watch the last two. While the Simpsons is my favourite cartoon and it's always airing here on TV, and I have some of it's DVD and games.
I really like it's plot, which is a satire to the suburban American way of life.
In 2002, the show received a backslash in Brazil because of the episode that took place here, which showed this country as being ridden with violence, promiscuity, monkeys roaming in the streets...
https://en.wikipedia.org/wiki/Blame_It_on_Lisa
https://youtu.be/VhrswtPLn_U