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http://en.wikipedia.org/wiki/Kumis
lactase persistence...
in Central Asians,general: 20%
in Kazakhs, traditionally herders: 25-32% (only 40.2% of these people have symptoms and 85-92% of the individuals are carriers of the 13.910*T allele.)
in Tajiko-Uzbeks, agriculturalists: 11-30% (only 40.8% of these people have symptoms and 53-58% of the individuals are carriers of the 13.910*T allele.)
The allele responsible for lactase persistence in Central Asia is the same as the one in Europe (13.910*T). Lactase persistence is connected with the proto-Turkic allele -13.910*T, which is most likely related to proto-Turkic R1b1 speakers in the Botai culture. These R1b1 people appeared 7500-8,300 years ago in the Pyrenees coming from the central Balkans and central Europe, originating in Central Asia. The relatively low prevalence of lactose malabsorption among the Kazakhs suggests that lactose persistence may be frequent in herding pastoralist populations of southwest Asia.
Surprise surprise, although many Central Asians are found by standard tests to have substantial amounts of lactose intolerance, they are able to consume large amounts of dairy products including horse milk without exhibiting any symptoms. But why? Remember the -13.910*T allele?
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Kumis is not milk, only a milk product.
The Central Asian persistence is European origin, but the Turks were not Europeans and they not lived in Europe or Central Asia before the Huns.lactase persistence...
in Central Asians,general: 20%
in Kazakhs, traditionally herders: 25-32% (only 40.2% of these people have symptoms and 85-92% of the individuals are carriers of the 13.910*T allele.)
in Tajiko-Uzbeks, agriculturalists: 11-30% (only 40.8% of these people have symptoms and 53-58% of the individuals are carriers of the 13.910*T allele.)
The allele responsible for lactase persistence in Central Asia is the same as the one in Europe (13.910*T). Lactase persistence is connected with the proto-Turkic allele -13.910*T, which is most likely related to proto-Turkic R1b1 speakers in the Botai culture. These R1b1 people appeared 7500-8,300 years ago in the Pyrenees coming from the central Balkans and central Europe, originating in Central Asia. The relatively low prevalence of lactose malabsorption among the Kazakhs suggests that lactose persistence may be frequent in herding pastoralist populations of southwest Asia.
Surprise surprise, although many Central Asians are found by standard tests to have substantial amounts of lactose intolerance, they are able to consume large amounts of dairy products including horse milk without exhibiting any symptoms. But why? Remember the -13.910*T allele?
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"The expansion time of the 13.910*T allele in Central Asia is also included in the wide confidence interval of the date estimated in Europe: 2,000 –20,000 yrs ago using surrounding haplotypes (Bersaglieri et al. 2004) or 3,400–42,000 yrs ago using microsatelittes (Coelho et al. 2005). These large confidence intervals for the time of the European expansion make it difficult to choose between an endogenous expansion in Central Asia vs. recurrent gene flow from Europe. One argument in favor of a low impact of recurrent gene flow is that the higher frequency of lactase persistence is found among Kazakhs who have the lowest proportion of “western” gene pool inferred from admixture analysis from autosomal microsatellite data: the percentage of gene pool from Europe Middle East is 25% for Kazakh and 55% for Tajiko-Uzbek (Martínez-Cruz et al. 2010). Therefore it could be that a local expansion of the allele arose in Central Asia. This could be an indirect genetic proof of the early domestication of horses for milk products as recently attested from archaeological remains (Outram et al. 2009)."
paper: Heyer et al. 2011. Lactase Persistence in Central Asia: Phenotype, Genotype, and Evolution. Human Biology, 83(3):379-392.
Or, that the −13.910-C/T polymorphism was already present in an ancestoral R1* population and it became naturally selected by both R1b and R1a popualtions due to their pasotralist lifestyles.
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Here it says the first milk drinkers originated in the Urals 6000-8000 years ago:
source: "Evolution zum Milchtrinker" Die Welt, 11. November 2004
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PARADOXON:
Yoshida et al. 1975, Gastroenterol Jpn. 10(1): 29-34. Studies on the etiology of milk intolerance in Japanese adults. PMID: 1234085
Abstract
"1. The incidence of milk intolerance is approximately 19% in Japanese adults when 200 ml of milk is given. However, a much greater incidence was assumed when considered under the criteria of Western standard. 2. The lactase activity was significantly greater in milk drinkers than non-drinkers. And, internationally, the active is higher in those nationalities whose milk consumption is greater. 3. Lactase is an adaptive enzyme and rather easily induced by lactose load feeding in animals. From the data of our own and of the literature, it was further confirmed that environmental factors play a more important role than genetic factors in the etio-pathogenesis of milk intolerance."
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