Homo Sapiens migrated into Africa 150.000 years ago

[Proto-Shaman]

Archaic hominin introgression in Africa contributes to functional salivary MUC7 genetic variation

Abstract
One of the most abundant proteins in human saliva, mucin-7, is encoded by the MUC7 gene, which harbors copy number variable subexonic repeats (PTS-repeats) that affect the size and glycosylation potential of this protein. We recently documented the adaptive evolution of MUC7 subexonic copy number variation among primates. Yet, the evolution of MUC7 genetic variation in humans remained unexplored. Here, we found that PTS-repeat copy number variation has evolved recurrently in the human lineage, thereby generating multiple haplotypic backgrounds carrying 5 or 6 PTS-repeat copy number alleles. Contrary to previous studies, we found no associations between the copy number of PTS-repeat copy number and protection against asthma. Instead, we revealed a significant association of MUC7 haplotypic variation with the composition of the oral microbiome. Furthermore, based on in-depth simulations, we conclude that a divergent MUC7 haplotype likely originated in an unknown African hominin population and introgressed into ancestors of modern Africans.

Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. 2017.
https://academic.oup.com/mbe/article.../molbev/msx206

[Kamal900]

I guess we're seeing the notion that modern humans originated from Africa is becoming more and more obsolete, huh?

[Proto-Shaman]

I guess we're seeing the notion that modern humans originated from Africa is becoming more and more obsolete, huh?

ironically yes. Once I read another paper that states Australian natives are the oldest people by DNA.