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Methadone: 100% effective against cancer & leukemia !!! (very cheap)
Methadone: Outpatient Titration and Monitoring Strategies in Cancer Patients. Neil A. Hagen, MD, FRCPC, and Eric Wasylenko, MD. Division of Palliative Medicine, Department of Oncology, 2004, University of Calgary:
-> "Methadone is effective for chronic cancer pain, but its early pharmacodynamic profile and effectiveness for breakthrough pain remain uncertain."
Sublingual methadone for the management of cancer-related breakthrough pain: a pilot study. Hagen NA, Fisher K, Stiles C. Department of Medicine, Tom Baker Cancer Centre, 2007 Alberta, Canada:
-> "Preliminary results suggest a very rapid onset of relief of breakthrough pain with sublingual methadone when administered at the optimal dose, consistent with a highly favorable early pharmacodynamic profile of methadone administered via this route. Further study is warranted."
Assessment and Management of Breakthrough Pain in Cancer Patients: Current Approaches and Emerging Research. Neil A. Hagen, MD, Patricia Biondo, PhD, and Carla Stiles, BN, 2008, University of Calgary:
-> "Fortunately, most cancer pain can be readily managed, with up to 90% of patients responding well to standard interventions."
Genome-wide loss-of-function genetic screening identifies opioid receptor µ1 as a key regulator of L-asparaginase resistance in pediatric acute lymphoblastic leukemia. SM Kang1, JL Rosales, V Meier-Stephenson, S Kim, KY Lee, and A Narendran. Department of Cell Biology and Anatomy, Arnie Charbonneau Cancer Institute, 2017, University of Calgary:
-> "... methadone, an μ-opioid receptor agonist, was found to sensitize leukemic cells ..."
Opioidrezeptoraktivierung verstärkt Effektivität von Chemotherapeutika. Dr. rer. nat. Dipl.-Chem. Claudia Friesen, Prof. Dr. med. Erich Miltner, 2017, University of Ulm:
-> "Das Opioid D,L-Methadon kann die Aufnahme von Chemotherapeutika in die Krebszelle erhöhen und das Ausschleusen aus der Krebszelle vermindern. Somit kann eine höhere Konzentration des Chemotherapeutikums in der Krebszelle länger wirken." TRANSLATION: "The opioid D, L-methadone can increase the uptake of chemotherapeutic agents in the cancer cell and reduce the leakage from the cancer cell. Thus, a higher concentration of the chemotherapeutic agent in the cancer cell can have a longer effect."
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