Post your MC1R SNPs - Do you have the Ginger Gene?

[Thor2009]

There are 6 major known mutations in the MC1R gene that can predispose you to having pale skin, freckles, and red hair: also known as being ginger.

Being recessive for one of these mutations almost guarantees you'll be 100% ginger, but having one or more heterozygous mutations has also been shown to have an effect on skin and hair color.
The more variant alleles you have, the stronger the effect appears to be.

There's a lot of interesting research, you can find most of it here: http://omim.org/entry/155555

So, which ginger mutations do you have?
Are you red haired, fair skinned, and freckled yourself? Do you have ginger family members?



SNP
Name
"Ginger" Allele


rs1805009/i3002507 (https://www.23andme.com/you/explorer/snp/?snp_name=i3002507) (23andMe)
Asp294His/D294H
C


rs2228479 (https://www.23andme.com/you/explorer/snp/?snp_name=rs2228479)
Val92Met/V92M
A


rs1805006 (https://www.23andme.com/you/explorer/snp/?snp_name=rs1805006)
Asp84Glu/D84E
A


rs1805007 (https://www.23andme.com/you/explorer/snp/?snp_name=rs1805007)
Arg151Cys/R151C
T


rs1805008 (https://www.23andme.com/you/explorer/snp/?snp_name=rs1805008)
Arg160Trp/R160W
T


rs1805005 (https://www.23andme.com/you/explorer/snp/?snp_name=rs1805005)
Val60Leu/V60L
T





My MC1R results
----------------
i3002507 - CG
rs2228479 - AG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GG
Total: 2 variants

I'm pretty ginger; my hair has a red tint to it, my beard is red, and I've got pale skin and freckles.
It runs in my family: my mom is ginger, with light red hair and pale freckled skin. There are actually a lot of gingers on that side of my family.

[Sea Warrior]

i3002507 - GG
rs2228479 - AG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GT
Total: 1 red variant and 1 blond variant.

I have a reddish tint to my hair and my beard contains quite a bit of red.

[Yehiel]

i3002507 - GG
rs2228479 - GG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GG

I have never really gotten sunburn, always tan, brown hair, some freckles (not visible on my skin)

[Jackson]

Me:
i3002507 - GG
rs2228479 - GG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GG

Father:
i3002507 - GG
rs2228479 - GG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GG
Grandfather:
i3002507 - GG
rs2228479 - GG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GG
Grandmother:
i3002507 - GG
rs2228479 - GG
rs1805006 - CC
rs1805007 - CT
rs1805008 - CC
rs1805005 - GG
Mother:
i3002507 - GG
rs2228479 - GG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GG
Aunt:
i3002507 - GG
rs2228479 - AG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GG

So my Aunt has 1 at rs2228479 and my Grandmother has one at rs1805007, that's it.

[Sehnsucht]

My MC1R results
----------------
i3002507 - GG
rs2228479 - GG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GG

Same for me. my mom, my aunt, and my grandmother. We just don't have any ginger alleles.

[Black Wolf]

My results. I have one on the last SNP in the list. Interestingly enough I seem to have inherited this from my paternal grandfather who is 100% Southern Italian who passed it onto my father who passed it onto me. I know this because both my grandfather and father have also tested and so has my mother.

i3002507 - GG
rs2228479 - GG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GT

Total: 1 variant

[Thor2009]

I probably should have gone into a bit more detail.

rs1805005/V60L is associated more with blond hair color, though it is weakly associated with red. It's not so much a "ginger gene" as the other five.

[Atlantic Islander]

No variants.

[Gaston]

I have none of them.

[sonofthedutch]

i3002507 GG
rs2228479 GG
rs1805006 CC
rs1805007 CC
rs1805008 CC
rs1805005 GG

Not very red indeed

[Mortimer]

There are 6 major known mutations in the MC1R gene that can predispose you to having pale skin, freckles, and red hair: also known as being ginger.

Being recessive for one of these mutations almost guarantees you'll be 100% ginger, but having one or more heterozygous mutations has also been shown to have an effect on skin and hair color.
The more variant alleles you have, the stronger the effect appears to be.

There's a lot of interesting research, you can find most of it here: http://omim.org/entry/155555

So, which ginger mutations do you have?
Are you red haired, fair skinned, and freckled yourself? Do you have ginger family members?



SNP
Name
"Ginger" Allele


rs1805009/i3002507 (23andMe)
Asp294His/D294H
C


rs2228479
Val92Met/V92M
A


rs1805006
Asp84Glu/D84E
A


rs1805007
Arg151Cys/R151C
T


rs1805008
Arg160Trp/R160W
T


rs1805005
Val60Leu/V60L
T





My MC1R results
----------------
i3002507 - CG
rs2228479 - AG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GG
Total: 2 variants

I'm pretty ginger; my hair has a red tint to it, my beard is red, and I've got pale skin and freckles.
It runs in my family: my mom is ginger, with light red hair and pale freckled skin. There are actually a lot of gingers on that side of my family.

i3002507 - GG
rs2228479 - GG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GG

[Mazik]

My MC1R results
----------------
i3002507 - GG
rs2228479 - GG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC

= no ginger genes, which is strange considering my brother got red hair. But he can tan quite well and have no freckles though.

blond hair gene: rs1805005 - GT

[Kadu]

I have one heterozygous mutation at rs1805007, no red hair, blackish brown actually but I do have pale skin - warm tones -, freckles and I'm indeed sun sensitive.

[Sehnsucht]

My paternal grandfather has one of the ginger alleles. I did not inherit it.

i3002507 - GG
rs2228479 - GG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GT

[larali]

i3002507 - GG
rs2228479 - GG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GT

Ah!! There it is. The last one.

I have reddish brown hair. Red also runs on my mom's side of the family.

http://i1205.photobucket.com/albums/bb427/bluefly102/DSCN4378.jpg

[Oneeye]

i3002507 - GG
rs2228479 - GG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GT

I have no head reds in my family, but my daughter has freckles on her face. My brother has freckles, and my dad had freckles as a kid.

[Atlantic Islander]

What I find interesting is that you don't have to have the genes to have red undertones, I don't have the variant, but when my hair is naturally highlighted by the sun I get reddish/auburn streaks. People with ashy/green undertones in their hair do not highlight reddish.

[Oneeye]

My grandfather:

i3002507 - GG
rs2228479 - GG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GG


Interestingly, my grandfather, who has been blonde his whole life, has GG at rs1805005.

[Damião de Góis]

Nothing, no ginger at all:

http://oi58.tinypic.com/2504bpi.jpg

[Mark]

My MC1R results
----------------
i3002507 - GG
rs2228479 - AG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GG

[Patches]

I have one variant at rs1805008 and I don't have any red to my hair or beard but I do have freckles and semi-pale skin. I can't think of any redheads in my family either...

[Hevo]

i3002507 - GG
rs2228479 - AG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GG

Hmm interesting, only my parental grandfather had red(with some blond) hair.

[larali]

Interestingly, my grandfather, who has been blonde his whole life, has GG at rs1805005.

Same with my hub.

Here are his results:

3002507 - GG
rs2228479 - AG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GG

Our kids have blonde hair. One is medium blonde and the other is very light blonde (not white). Both have strawberry tones.

[Black Wolf]

Same with my hub.

Here are his results:

3002507 - GG
rs2228479 - AG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GG

Our kids have blonde hair. One is medium blonde and the other is very light blonde (not white). Both have strawberry tones.

You are back! :)

[Loki]

rs1805005 - GG
rs1805008 - CT
rs1805007 - CC
rs1805006 - CC
rs2228479 - GG
i3002507 - GG

[Longbowman]

GG
GG
CC
CT
CC
GG

Makes sense. My beard grows blonde/black on the chin.

[Grace O'Malley]

Here are mine

i3002507 GG
rs2228479 GG
rs1805006 CC
rs1805007 CC
rs1805008 CT
rs1805005 GT

I'm fair skinned with freckling and have brown hair more on the light brown side.

[Grace O'Malley]

Does this mean I have a red variant and blond variant?

[Prisoner Of Ice]

Does this mean I have a red variant and blond variant?

Yes, the second to last is red and bottom one is blonde.

[Prisoner Of Ice]

You should post pics and get classified some day.

[Grace O'Malley]

Yes, the second to last is red and bottom one is blonde.

Thanks Melonhead I just wanted to make sure. I was blond until I was about 13 then my hair darkened to brown. I have a lot of red haired family members as well.

[Prisoner Of Ice]

Thanks Melonhead I just wanted to make sure. I was blond until I was about 13 then my hair darkened to brown. I have a lot of red haired family members as well.

Interesting, that happens in my family too.

[Catkin]

GG
AG
CC
CC
CC

GG

Ginger gene positive, but no blonde.

[Graham]

Thanks Melonhead I just wanted to make sure. I was blond until I was about 13 then my hair darkened to brown. I have a lot of red haired family members as well.
What you get here Alice, being Irish and all? Interested.

http://www.theapricity.com/forum/showthread.php?71203-Freckling-amp-Red-Hair-Markers

[Chrissi]

i3002507 - GG
rs2228479 - GG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GT

1 variant

Im blond like my father, dont know of any redheaded relatives

[Chrissi]

Interestingly, my grandfather, who has been blonde his whole life, has GG at rs1805005.

How is that possible? Are there other genes/SNPs that determine hair colour?

[Bartox]

i3002507 - CG
rs2228479 - GG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GT

Paternal grandmother was a redhead

[Proctor]

I have none of the variants, which is pretty interesting considering my paternal grandmother was a ginger.

[Stanley]

i3002507 GG
rs2228479 GG
rs1805006 CC
rs1805007 CC
rs1805008 CT
rs1805005 GT

2 variants

There's a ginger element to me—I freckle slightly and my dark hair has a reddish tint to it.


Here are mine

i3002507 GG
rs2228479 GG
rs1805006 CC
rs1805007 CC
rs1805008 CT
rs1805005 GT

I'm fair skinned with freckling and have brown hair more on the light brown side.

Exact same as mine.

[Siberia62]

Sweet, I get two variants.

GG
AG
CC
CC
CC
GT

This could make some sense, seeing as my parents have both told me that their mother's had reddish-brown hair. This also shows in my sister's hair and also in my beard, which is mostly red with bits of blonde and brown in the middle.

[EdAlencar]

From FamilyTreeDNA:

rs1805009 - not found
rs2228479 - AG
rs1805006 - CC
rs1805007 - not found
rs1805008 - CC
rs1805005 - GG

1 variant

I have two cousins who have reddish brown hair, but that's about it. Almost everyone in my family has blond hair, but: rs1805005 - GG :bored:

http://i.imgur.com/OWUSrP3.jpg
http://i.imgur.com/NcJSLA8.jpg

:(

[Thor2009]

How is that possible? Are there other genes/SNPs that determine hair colour?
http://www.theapricity.com/forum/showthread.php?113714-Post-your-MC1R-SNPs-Do-you-have-the-Ginger-Gene&p=2375236&viewfull=1#post2375236

rs1805005 is an MC1R mutation, but linked to light blond hair color rather than red hair color. I just lumped it in because it's another important MC1R mutation.

[Not a Cop]

I'm GT at rs1805005

[Übermensch]

My MC1R results
----------------
i3002507 - GG
rs2228479 - AG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GG
Total: 1 variants
I have dark blond hair with reddish strands, extremly fair skin (i don't tan very well and i need sunscreen), some freckles, my aunt (father's sister) is a pure ginger with a lot of freckles and milkish skin.

I'm also CT on rs1667394 so i also got the blond allele, i was orange-blond haired as a kid, now a darker blond:

https://fbcdn-sphotos-h-a.akamaihd.net/hphotos-ak-xfa1/v/t34.0-12/10807920_798664066864944_2138457780_n.jpg?oh=74a7f 68f3ae0be1d21631669725f4d1c&oe=546B023D&__gda__=1416303390_18c04fbe477b4e8c3c4ea1c8e911b90 f

My hair now

https://fbcdn-sphotos-h-a.akamaihd.net/hphotos-ak-xpa1/v/t34.0-12/10807840_798666366864714_1342721691_n.jpg?oh=716d2 45c1ffaf84b6bde22ef3b6fae53&oe=546B30E4&__gda__=1416277444_6c9b74afa4f5428e3c95669b222fde4 4

As a child

[Reith]

Looks like I have one. Hair was platinum blonde changed to dark blonde with maturity. I tan well.

I do have a few red whiskers though.

My MC1R results
----------------
i3002507 - GG
rs2228479 - AG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GG

[Longbowman]

Having grown my beard out I see where all the light-haired pigmented genes went. Soon they'll call me Barbarossa.

[MsSPF]

i3002507- G / G
rs2228479 - A / G
rs1805006 - C/C
rs1805007 - C/C
rs1805008 - C/C
rs1805005 - G/G

lol one of my great grandmother was a ginger

[Kaspias]

rs1805009 GG
rs2228479 GG
rs1805006 CC
rs1805007 TC
rs1805008 CC
rs1805005 TT

3 Variants. I have reddish beard, fair skin.

[frankhammer]

i3002507- G / G
rs2228479 - G / G
rs1805006 - C / C
rs1805007 - C / C
rs1805008 - C / C
rs1805005 - G / T

[Rocinante]

rs1805009 - CG : Red hair carrier, higher risk of melanoma
rs2228479 - GG : Common in complete genomics
rs1805006 - CC : Common in complete genomics
rs1805007 - Not tested
rs1805008 - CC : Common in complete genomics
rs1805005 - GG : Common in complete genomics

[mitalit]

i3002507 - G / G
rs2228479 - G / G
rs1805006 - not genotyped
rs1805007 - C / C
rs1805008 - C / C
rs1805005 - G / T

[Rocinante]

i3002507 - G / G
rs2228479 - G / G
rs1805006 - not genotyped
rs1805007 - C / C
rs1805008 - C / C
rs1805005 - G / T

Tienes alguno positivo? Creo que sí, vamos de tu parte no sería extraño.

[mitalit]

Tienes alguno positivo? Creo que sí, vamos de tu parte no sería extraño.

Solo el ultimo

[Rocinante]

Solo el ultimo

Eres portador del alelo de cabello rubio claro, no es de extrañar. A mí me salió el portador de cabello rojo pero no conozco gente con cabello rojo (si con barba muy roja) pero rubios hay bastantes, y eso que no lo porto al parecer.

[mitalit]

Eres portador del alelo de cabello rubio claro, no es de extrañar. A mí me salió el portador de cabello rojo pero no conozco gente con cabello rojo (si con barba muy roja) pero rubios hay bastantes, y eso que no lo porto al parecer.

Yo tengo el pelo de los sobacos de color rojo jajaja, y mi padre también. Supongo que no tiene nada que ver, tiene pinta de rasgo semita.

[Rocinante]

Yo tengo el pelo de los sobacos de color rojo jajaja, y mi padre también. Supongo que no tiene nada que ver, tiene pinta de rasgo semita.

El cabello rojo es únicamente europeo, nada de semita, de hecho el cabello castaño es únicamente europeo por origen, todo por los EHG.

Eso es que eres 1/4 irlandés y nos quieres intentar colar la del abuelo napolitano, tu eres un pilluelo.

[mitalit]

El cabello rojo es únicamente europeo, nada de semita, de hecho el cabello castaño es únicamente europeo por origen, todo por los EHG.

Eso es que eres 1/4 irlandés y nos quieres intentar colar la del abuelo napolitano, tu eres un pilluelo.

:rolleyes:

[Benyzero]

I have two variant according to this, I have other sun sensitivity haplotypes ,and despite I can tan pretty good, but usually burn myself ugly when stay on the sun for long. bet these are from my grandma, she is very pale, blonde.


i3002507 - GG
rs2228479 - AG
rs1805006 - Not found
rs1805007 - CT
rs1805008 - CC
rs1805005 - GG

[Rædwald]

i3002507 - GG
rs2228479 - GG
rs1805006 - CC
rs1805007 - CC
rs1805008 - CC
rs1805005 - GG

Odd considering my brother has red hair, and I have red/mixed beard.

[Rocinante]

¿Como puedo sacar esos resultados?

En el raw data de 23andme (o de LivingDNA) lo abres y buscas esos SNPs, luego las 2 letras que te salgan definen el cromosoma.

[Rocinante]

i3002507 - G/G
rs1805009 - No tested.
rs2228479 - G/G
rs1805006 - No tested.
rs1805007 - C/C
rs1805008 - C/C
rs1805005 - G/G

Ya vi, no eres portador del cabello rojo. Mira aqui buscas los SNPs https://www.snpedia.com/index.php/Rs2228479 teoricamente es el mismo metodo que usaba para buscar los haplogrupos.

[Rocinante]

No, si eso ya lo sé, pero no sé según YourDNAPortal también tengo como 4 veces más posibilidades de tener ojos azules y pelo rubio y que tengo una variante de pelo rubio claro, pero no lo sé

Ojo, estas son mas que todo enfocadas en cabello rojo, no rubio, a pesar que algunos de estos SNPs tambien hablen de hibrido rubio/rojo. Hay muchisimos SNPs de cabello rubio y lo otro.