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wvwvw
06-26-2014, 03:56 AM
Ibuprofen can help diabetes and dementia patients from growing old before their time
The popular over the counter painkiller gave ageing mice a new lease of life
Could help patients with age-related illnesses diabetes and dementia
While it's unlikely to improve illness, drug might slow its progression
By FIONA MACRAE
PUBLISHED: 00:45 GMT, 25 June 2014 | UPDATED: 10:48 GMT, 25 June 2014

It already works wonders on pounding headaches. But ibuprofen could also hold the secret to a long and healthy life

In a series of remarkable experiments, the popular painkiller gave ageing mice a new lease of life.
Researchers from Newcastle University say it might help people with age-related illnesses such as diabetes and dementia from growing old before their time.

While it is unlikely to improve their illness, the inexpensive drug might slow its progression – and help prevent them from developing other debilitating conditions.

As surprising as this might seem, researcher Thomas von Zglinicki said it is not unusual for a drug that is developed to treat one thing to have other powers.

At the heart of Professor von Zglinicki’s theory is the inflammation that causes pain, swelling and fever we experience when our body is fighting off an infection.

This inflammation is also present in a milder but longer-term form in age-related diseases such as diabetes, dementia and arthritis.

Using GM mice, the professor showed that far from being a result of ageing, this inflammation helps drive it. Mice with genes that made them particularly prone to inflammation aged twice as quickly as normal animals.

Just like people, their hair turned grey and fell out, they lost weight, became unsteady on their feet and had heart problems. They also lived half as long as usual.

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Read more: http://www.dailymail.co.uk/health/article-2668602/Common-painkiller-help-prevent-premature-ageing-Ibuprofen-help-diabetes-dementia-patients-growing-old-time.html#ixzz35iKIMENx

wvwvw
06-26-2014, 04:10 AM
It is true that it is the hidden inflammation in our bodies that causes cancer and many other diseases.

When we are fat for example our bodies are in a constant state of inflammation. That is why obesity is a trigger factor for many diseases and aging.

06 MAR
2013
A Mechanism by Which Fat Causes Chronic Inflammation
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The real monster when it comes to fat tissue and long term health appears to be inflammation, however. Temporary inflammation is a necessary portion of the response to damage and disease by the immune system, but chronic, unremitting inflammation accelerates progress towards frailty and ill-health. Indeed, it shows up as a contributing factor in degenerative aging later in life as the immune system becomes increasingly damaged and erratic. This process is known as inflammaging in some parts of the research community.

Distinct from the aging of the immune system, fat tissue itself spurs chronic inflammation. This has been known for some time, and researchers have been chasing down a detailed explanation as to why this is so. You might look at the connection to macrophage behavior, for example, or cytokine signaling. The more visceral fat you have, the higher your level of chronic inflammation - and thus the more damage gets added per unit time to the state of your biology. Aging itself is nothing more than damage and the reactions of bodily systems to that damage.

Here researchers present a fairly detailed account of how they think fat cells are causing this issue. You might look at the original paper as well as the more digestible research publicity materials linked below:

Obesity makes fat cells act like they're infected

Quote:High calorie diets cause [fat] cells to make major histocompatibility complex II, a group of proteins usually expressed to help the immune system fight off viruses and bacteria. In overweight mice and humans the fat cells, or adipocytes, are issuing false distress signals - they are not under attack by pathogens. But this still sends local immune cells into a tizzy, and that causes inflammation.
https://www.fightaging.org/archives/2013/03/a-mechanism-by-which-fat-causes-chronic-inflammation.php

While fasting and calorie restriction reduces inflammation and aging, and switches on our longevity genes:

http://i.dailymail.co.uk/i/pix/2010/10/26/article-1323758-0BC412C1000005DC-267_233x423.jpg
Professor Kenyon has found out why drastically reducing calories has such a remarkable effect:
http://www.dailymail.co.uk/health/article-1323758/Can-cutting-Carbohydrates-diet-make-live-longer.html#ixzz35iOAhuAW

♥ Lily ♥
07-01-2014, 02:52 PM
That's interesting. It's a good anti-inflammatory drug. I take high dosages of this pill in prescription along with much stronger opiate-based prescription painkillers along with codeine pills too because ibuprofen by itself isn't strong enough. I'm pleased ibuprofen has some good effects even if it doesn't numb pain in your head like the other painkillers do.