Blood transfusion effect on DNA

[Sveta]

Does blood transfusion change one's haplogroup?

[Kale]

Change? No. Give a different reading in a test? Maybe.

All cells in the body are replaced eventually, so eventually the foreign blood will be as well. But if you got a transfusion, then immediately went and got a DNA test via blood, the lab may get confused being that multiple results could show up.

EDIT: Don't take this as law, I'm no blood transfusion expert.

[Dictator]

No you can't whitewash people through blood transfusion if that's what you have in mind.

[Kale]

No you can't whitewash people through blood transfusion if that's what you have in mind.

Right, you gotta use stem cells.

[Stanley]

First, blood isn't typically used in DNA genotyping.

Second, red blood cells have neither a nucleus (where autosomal DNA is) nor mitochondria, so there's no genetic information to gather from them to begin with.

So... Only if you randomly happened to test a white blood cell provided by the transfusion...

In conclusion, the answer is pretty much no.

[Sveta]

What about bone marrow transplantation? Eventually, bone marrow is what produces the leukocytes which carry DNA, right? In that case, transplanted bone marrow should be always producing white blood cells containing the donor's DNA.

[Stanley]

Sure, but that would only be in one cell type of many. It doesn't change their actual genetic profile. And why would someone who'd undergone bone marrow transplantation want to get their haplogroup tested via their blood anyway?

[Sveta]

Sure, but that would only be in one cell type of many. It doesn't change their actual genetic profile. And why would someone who'd undergone bone marrow transplantation want to get their haplogroup tested via their blood anyway?

I am not worried about the testing part. I am just wondering whether it is possible to possess more than one lineage in one body. Seems to be yes.

[Smaug]

No, but if you do a blood test after a transfusion it will probably result in different results.

[Prisoner Of Ice]

You can change your blood type with a transfusion but it may only work at birth. Sorry but I don't know how red cells are made so can't say for sure.