Marusya
07-01-2015, 10:40 PM
Is it mere coincidence, or do people with blue eyes really run a higher risk of being alcoholics? A new study out of the University of Vermont suggests that the link not only exists, but it appears to be a genetic one.
Reporting in the American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, the researchers find that among European-Americans, those with light-colored eyes — described as ones that are green, gray, and brown in the center — have higher rates of alcohol dependency than Euro-Americans with dark brown eyes; that link is strongest in blue-eyed people.
http://onlinelibrary.wiley.com/doi/10.1002/ajmg.b.32316/abstract;jsessionid=25216A1EB2665F144E14351FB99D25 EE.f03t01
“We still don’t know the reason,” researcher Dawei Li says in a University of Vermont press release, but they do know that the very genes that determine eye color are situated along the same chromosome as genes that are known to be linked to alcohol dependency.
It’s not the first time the eye color-alcohol link has been found: A 2000 study arrived at a similar conclusion, noting that among one sample set of women, dark-eyed females averaged 4.91 drinks in the last month to light-eyed females’ 5.78.
Blue eyes also correlate with other attributes, including lower pain tolerance and higher competitiveness, reports Medical Daily (http://www.medicaldaily.com/eye-color-explained-5-surprising-things-your-baby-blues-say-about-your-health-and-310792). “This suggests an intriguing possibility — that eye color can be useful in the clinic for alcohol dependence diagnosis,” says lead researcher Arvis Sulovari. The researchers say these findings could help us better understand the roots of not only alcoholism but other psychiatric illnesses as well.
https://www.yahoo.com/health/this-eye-color-is-linked-to-alcoholism-122943625863.html
From the University of Vermont press release: http://www.newswise.com/articles/study-suggests-link-between-eye-color-and-alcohol-dependence
The authors found that primarily European Americans with light-colored eyes – including green, grey and brown in the center – had a higher incidence of alcohol dependency than those with dark brown eyes, with the strongest tendency among blue-eyed individuals. The study outlines the genetic components that determine eye color and shows that they line up along the same chromosome as the genes related to excessive alcohol use.
But, Li says, “we still don’t know the reason” and more research is needed.
Li came to the University of Vermont in 2012 and has studied psychiatric genetics for a decade. During that time, he has worked with physicians and scientists throughout the Northeast who have collaborated to build a clinical and genetic database of more than 10,000 individuals, mostly African Americans and European Americans, diagnosed with at least one psychiatric illness. Many have multiple diagnoses of diseases, including depression, schizophrenia and bipolar disorder, as well as addiction and alcohol or drug dependence.
“These are complex disorders,” he says. “There are many genes, and there are many environmental triggers.”
From that extensive database, Li’s and Sulovari’s study filtered out the alcohol-dependent patients with European ancestry, a total of 1,263 samples. After Sulovari noticed the eye-color connection, they retested their analysis three times, arranging and rearranging the groups to compare age, gender and different ethnic or geographic backgrounds, such as southern and northern parts of the continent.
Next, Li wants to delve deeper into the relationship between cultural background and genetic makeup, continuing his quest to find the mechanisms of mental illness.
His greatest challenge: All the genes identified in the past 20 years “can only explain a small percentage of the genetics part that has been suggested,” he says. “A large number is still missing, is still unknown.”
Li just submitted a grant application to pursue those missing genes and is working on another proposal for funding to continue that pursuit using the large database of patient samples. His work with Sulovari has provided a strong stepping-stone, he says.
“What has fascinated me the most about this work has been investigating the interface between statistics, informatics and biology,” says Sulovari. “It’s an incredible opportunity to study genomics in the context of complex human diseases.”
Reporting in the American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, the researchers find that among European-Americans, those with light-colored eyes — described as ones that are green, gray, and brown in the center — have higher rates of alcohol dependency than Euro-Americans with dark brown eyes; that link is strongest in blue-eyed people.
http://onlinelibrary.wiley.com/doi/10.1002/ajmg.b.32316/abstract;jsessionid=25216A1EB2665F144E14351FB99D25 EE.f03t01
“We still don’t know the reason,” researcher Dawei Li says in a University of Vermont press release, but they do know that the very genes that determine eye color are situated along the same chromosome as genes that are known to be linked to alcohol dependency.
It’s not the first time the eye color-alcohol link has been found: A 2000 study arrived at a similar conclusion, noting that among one sample set of women, dark-eyed females averaged 4.91 drinks in the last month to light-eyed females’ 5.78.
Blue eyes also correlate with other attributes, including lower pain tolerance and higher competitiveness, reports Medical Daily (http://www.medicaldaily.com/eye-color-explained-5-surprising-things-your-baby-blues-say-about-your-health-and-310792). “This suggests an intriguing possibility — that eye color can be useful in the clinic for alcohol dependence diagnosis,” says lead researcher Arvis Sulovari. The researchers say these findings could help us better understand the roots of not only alcoholism but other psychiatric illnesses as well.
https://www.yahoo.com/health/this-eye-color-is-linked-to-alcoholism-122943625863.html
From the University of Vermont press release: http://www.newswise.com/articles/study-suggests-link-between-eye-color-and-alcohol-dependence
The authors found that primarily European Americans with light-colored eyes – including green, grey and brown in the center – had a higher incidence of alcohol dependency than those with dark brown eyes, with the strongest tendency among blue-eyed individuals. The study outlines the genetic components that determine eye color and shows that they line up along the same chromosome as the genes related to excessive alcohol use.
But, Li says, “we still don’t know the reason” and more research is needed.
Li came to the University of Vermont in 2012 and has studied psychiatric genetics for a decade. During that time, he has worked with physicians and scientists throughout the Northeast who have collaborated to build a clinical and genetic database of more than 10,000 individuals, mostly African Americans and European Americans, diagnosed with at least one psychiatric illness. Many have multiple diagnoses of diseases, including depression, schizophrenia and bipolar disorder, as well as addiction and alcohol or drug dependence.
“These are complex disorders,” he says. “There are many genes, and there are many environmental triggers.”
From that extensive database, Li’s and Sulovari’s study filtered out the alcohol-dependent patients with European ancestry, a total of 1,263 samples. After Sulovari noticed the eye-color connection, they retested their analysis three times, arranging and rearranging the groups to compare age, gender and different ethnic or geographic backgrounds, such as southern and northern parts of the continent.
Next, Li wants to delve deeper into the relationship between cultural background and genetic makeup, continuing his quest to find the mechanisms of mental illness.
His greatest challenge: All the genes identified in the past 20 years “can only explain a small percentage of the genetics part that has been suggested,” he says. “A large number is still missing, is still unknown.”
Li just submitted a grant application to pursue those missing genes and is working on another proposal for funding to continue that pursuit using the large database of patient samples. His work with Sulovari has provided a strong stepping-stone, he says.
“What has fascinated me the most about this work has been investigating the interface between statistics, informatics and biology,” says Sulovari. “It’s an incredible opportunity to study genomics in the context of complex human diseases.”