Identify your genotype via SNPs with your raw data

[de Burgh II]

This occurred to me yesterday after looking through 23andme or any equivalent genetic company. Simply type the designated SNPs into SNPedia here and associated terms like "personality traits", "skin color", etc. to get basic genotype possibilities that you have via your raw data: http://www.snpedia.com/index.php/SNPedia

More references here you can look through if you want a basic idea: http://www.eupedia.com/genetics/psychological_traits_snp.shtml

Eye color: SNP: Rs4778241 on OCA2 gene:
rs4778241 is part of a haplotype spanning 166kB on chromosome 15, defined by 13 SNPs listed below, found in 97% of all Caucasians with blue eyes. In this haplotype, variations in rs1129038 and rs12913832 are relatively common in Caucasians though rare among other ethnic groups.[PMID 18172690]
The "h-1" haplotype found in homozygous state in 97% of individuals with blue eye color is composed as follows [PMID 18172690]:

Possible genotypes:

Geno Mag Summary
(A;A) usually brown eye color
(A;C) usually brown eye color
(C;C) blue eye color if part of blue eye color haplotype

Ex. My genotype: AC

http://www.snpedia.com/index.php/Rs4778241

Skin pigmentation: SNP: Rs1426654 on the SLC24A5 gene:

This SNP influences skin pigmentation. The allele, A111T, rs1426654(A), indicates light-skinned european ancestry. [PMID 16847698, PMID 16357253]
It appears as if this SNP is a relatively new one in human evolution; one estimate [PMID 17182896] is that the rs1426654(A) allele, in other words, light skin pigmentation, spread through the European population around 6,000 - 12,000 years ago. Prior to that, "European ancestors" were most likely relatively brown-skinned. Another study ([PMID 24048645OA-icon.png]) has concluded that almost individuals carrying the A111T variant can trace ancestry back to a single person who most likely lived at least 10,000 years ago.

This SNP is one of three from the SLC24A5 gene that can be analyzed to categorize the ancestry of a person as either European, African, or Asian, based on a 2009 study.[PMID 19440451OA-icon.png]

Possible genotypes:

Geno Mag Summary
(A;A) 2.7 probably light-skinned, European ancestry
(A;G) 2.5 mixed African/European ancestry possible
(G;G) 2.6 probably darker-skinned, Asian or African ancestry

Ex. My genotype: AA

http://www.snpedia.com/index.php/Rs1426654

Intelligence (less cognitive decline with age) associated with rs821616 on the DISC1 gene :

Women with two rs821616(T) SNPs seem to experience more rapid cognitive decline as they age compared to men. [PMID 16054297]
[PMID 17673452] 13 single-nucleotide polymorphisms (SNPs) in 723 members of 179 Finnish Bipolar disorder families.

Possible genotypes:

Geno Mag Summary
(A;A) cognitive decline in older women
(A;T) ?
(T;T) normal

Ex. My genotype: AA

http://www.snpedia.com/index.php/Rs821616


Intelligence: supposedly associated with the Rs363050 SNP on the SNAP25 gene:
SNPs in the SNAP25 gene were initially [PMID 17160701] linked to intelligence but have failed to replicate [PMID 19418213].
While now suspect, the original work can be found in [PMID 16801949].

The (A;A) genotype averaged 2.84 PIQ points higher than the (A;G) genotype, which averages 2.8 PIQ points higher than the (G;G) genotype (p=0.0002). Variance in this SNP may account for 3.4% of the phenotypic variance in PIQ.[PMID 16801949]

rs363050 is in close linkage with rs353016, with r2 = 0.98, such that the rs363050(A) allele typically is linked to the rs353016(T) allele. For SNPs rs363039 - rs363043 - rs353016, respectively, the haplotype C-T-T is most associated with higher intelligence in children, whereas the haplotype C-C-T is most associated in adults (SNPs oriented as in dbSNP). [PMID 17908175]

Possible genotypes:

Geno Mag Summary
(A;A) 1.1 2.84 PIQ points higher than AG genotype
(A;G) 1.1 2.8 PIQ points higher than GG genotype
(G;G) 0.1 2.8 PIQ points lower than AG genotype

My genotype: AA

More info at: http://www.snpedia.com/index.php/Rs363050

Empathy: associated with the Rs53576 SNP on the OXTR gene:
rs53576 is a silent G to A change in the oxytocin receptor (OXTR) gene. Studies have demonstrated that individuals with the G allele are more empathetic, feel less lonely, employ more sensitive parenting techniques, and have lower rates of autism (discussed in [PMID 20724662OA-icon.png])
The blog Not Exactly Rocket Science discusses that Americans with (G;G) tend to be more sensitive parents, more empathetic and less lonely than those with an ‘A’. In a Korean population people with (G;G) were less likely to seek support from their peers.

[PMID 20724662OA-icon.png] Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking.

[PMID 19934046OA-icon.png] Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. In brief, people with the G;G genotype were better able to discern the emotional state of others than those who carried the A-allele (blog summary found here). The study encompassed 192 participants of both sexes and mixed ethnicities. The study subjects underwent a number of tests to determine their level of empathy and stress reactivity. They found that G;G individuals performed significantly better on the behavioral measure of empathy and were 22.7% less likely to make a mistake on the "Reading the Mind in the Eyes Test" (RMET) (a behavioural measure of empathic accuracy) than A;A/A;G individuals (P = 0.005). Similarly, G;G individuals reported higher levels of dispositional empathy than A;A/A;G individuals: mean (SE) = 3.69 (0.06) and 3.53 (0.04) for G;G and A;A/A;G, respectively (P = 0.025), and were less affected by stress (as measured by their heart rates): mean (SE) = 72.1 (0.54) and 78.4 (1.19) for G;G and A;A/A;G, respectively.

[PMID 19376182] Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects.

[PMID 19015103OA-icon.png] This study examined the association between the OXTR gene and parenting. A total of 176 mothers of toddlers were included in the study. After controlling for marital discord, depression, and education status, rs53576 was found to significantly correlate with parenting, with the G;G genotype being associated with a significantly more sensitive parenting style than A;A or A;G genotypes. However, they concluded that the major factor influencing parenting was the maternal education level.

Possible genotypes:

Geno Mag Summary
(A;A) 2.8 Lack of empathy?
(A;G) 2.8 Lack of empathy?
(G;G) 2.5 Optimistic and empathetic; handle stress well

My genotype: GG

http://www.snpedia.com/index.php/Rs53576

[Damião de Góis]

I score exactly the same as you on every case. In my opinion a single SNP is not enough to make conclusions on anything.

[de Burgh II]

I score exactly the same as you on every case. In my opinion a single SNP is not enough to make conclusions on anything.

I agree, since something like eye color is polygenic (controlled by multiple genes) so they would need a considerable amount of SNPS to determine this phenotypic trait. As well as taking in consideration that they got the human genome mapped out for the most part. As well as intelligence being determined by an interaction between one's genetics and their environment (multifactorial) that go hand and hand.

I simply thought it would be an interesting thing to share to some people to show how some genes can be identified so they could look into it themselves if they wanted to. :p

[Era]

My eyes are green more but this shows as blue : rs4778241 A or C CC

[de Burgh II]

My eyes are green more but this shows as blue : rs4778241 A or C CC

I would say take it with a grain of salt since this is one SNP out of many SNPs that is controlled by many genes such as eye color. This is merely a rudimentary level of genetics as a means to get some people curious about it by throwing out some examples for people to look into.

[Era]

I would say take it with a grain of salt since this is one SNP out of many SNPs that is controlled by many genes such as eye color. This is merely a rudimentary level of genetics as a means to get some people curious about it by throwing out some examples for people to look into.

Do you know what's the snp for hair color, blonde and brown?

[de Burgh II]

Do you know what's the snp for hair color, blonde and brown?

Sadly, as far as I know I only read into SNPS identified for blonde hair as well as red hair.

Here is a good article for the SNPS for blonde hair by 23andme that idenitfied three SNPS:
Genes
KITLG
HERC2
SLC24A4

SNPs
rs12821256
rs1667394
rs12896399

Blonde allele
C
T
T

Scientists haven’t agreed on whether blondes indeed have more fun, but at least there is some consensus on what makes their hair blond.
image: http://blog.23andme.com/wp-content/uploads/2015/01/Blond-Hair-270x300.png

Blond Hair

23andMe scientists looking at the biology behind hair color found three genetic variants already known to be strongly associated with having golden locks among 23andMe customers with Northern European ancestry.

The three variants are on or near the genes HERC2, KITLG and SLC24A4.

These findings among 23andMe customers confirm known associations reported on in several other published studies over the last few years.

Hair color is a complex trait, meaning more than one genetic variant influences whether a person has light or dark hair. And these three genetic variants by no means account for all the genetic factors that influence hair color, but at least for people with Northern European ancestry they explain a lot.

A pigment molecule called melanin determines the color of your hair. People with higher levels of the brown-black form of melanin have darker hair, while people with the lower levels have lighter hair. About 20 percent of 23andMe customers report having light or dark blond hair.

While blond hair is most common in people of Northern European ancestry, it is also found in people without European ancestry, but the biology behind blond hair in those populations is different. For example, between five to ten percent of Solomon Islanders have blond hair that is caused by a single variant in the TYRP1 gene.

Part of the reason researchers look at traits like hair and eye color, is because it provides a broader insight into the biology of complex traits. The color of your hair is not as simple as many might think. For instance simply having one or two blond hair alleles does not mean that you will have blond hair. In fact most people with just two blond hair variants don’t have blond hair. Only in people with five or more blond hair alleles do we see a majority of them with light hair. By studying complex traits like hair color scientists can sometimes gain better understanding about the genetics of other conditions.

Just looking at research about blond hair, for example, has informed scientists about the finely tuned process of gene expression.

A 2014 study led by researchers at Stanford looked specifically at the variant nearby, but not in the KITLG gene. The study was fascinating because the researchers showed that a variant in so-called “junk” DNA has a strong influence on the expression of KITLG, which in turn influences hair color. Instead of simply turning on or off expression of the KITLG gene, this variant dialed down the gene expression levels, changing the hair color along a blond to brown gradient.

http://blog.23andme.com/health-traits/blonde-on-blonder/

I'll let you know if I come across anything else concerning hair color. :thumb001:

[Era]

Very interesting Armstrong. I got this
KITLG rs12821256 C - TT
HERC2 rs1667394 T - TT
SLC24A4 rs12896399 T - GT

[Damião de Góis]

SNPs
rs12821256
rs1667394
rs12896399

Blonde allele
C
T
T



On these i get:

rs12821256 - TT
rs1667394 - TT
rs12896399 - GT

I have medium brown hair, but was blonde as a young infant.

[de Burgh II]

Very interesting Armstrong. I got this
KITLG rs12821256 C - TT
HERC2 rs1667394 T - TT
SLC24A4 rs12896399 T - GT

I can only assume that you have enough SNPs for it to be expressed even for some SNPs that they didn't list. Congrats! :)

[de Burgh II]

On these i get:

rs12821256 - TT
rs1667394 - TT
rs12896399 - GT

I have medium brown hair, but was blonde as a young infant.

I would say you carry the blonde allele so I would assume your heterozygous for the blonde gene. Congrats as well! :)

[Era]

I can only assume that you have enough SNPs for it to be expressed even for some SNPs that they didn't list. Congrats! :)

I also had the red hair gene but that doesnt show on me. Thanks :D

[de Burgh II]

I also had the red hair gene but that doesnt show on me. Thanks :D

I would highly recommend this heredity calculator since its quite accurate. I always thought I was predominantly black haired, but supposedly it shares a co-dominance with blonde hair. All you have to do is insert your raw data and let it rip! :thumbs up

http://dna.frieger.com/calc-heredity.php

[de Burgh II]

Side Note: every gene operates independently that applies to eye color, hair color, pigmentation, etc. That is why you can get some irregular varieties such as blonde hair with brown/ green eyes; red hair with brown eyes, black hair with blue eyes, etc. Blonde hair with blue eyes for example is strongly correlated with each other on the OCA2 gene. That is why is quite prevalent/common nowadays that people associate it with.

[Zmey Gorynych]

Eye Color.
Rs4778241 - CC (I have gray eyes)

Skin Color.
Rs1426654 - AA (pale skin)

Intelligence/Cognitive Decline
rs821616 - AT (the question mark means that it's not clear whether there is decline with age or not?)

Intelligence
Rs363050 - AG (not particularly bright, eh :) )

Empathy
Rs53576 - GG (at least I have a good heart)

Blonde Hair
rs12821256 - TT
rs1667394 - TT
rs12896399 - GG

Wog?

I did that heredity report on frieger.com and it says that I have(had) a 55% chance of being blond and 45% chance of being black haired (I'm the latter). Children have a 40% chance of being blond and 32% of being black haired. I'd say that there's a 100% chance of being black haired unless their mother is a blonde.

This thing works. It shows the correct eye color, blood type, etc.

[de Burgh II]

Eye Color.
Rs4778241 - CC (I have gray eyes)

Skin Color.
Rs1426654 - AA (pale skin)

Intelligence/Cognitive Decline
rs821616 - AT (the question mark means that it's not clear whether there is decline with age or not?)

Intelligence
Rs363050 - AG (not particularly bright, eh :) )

Empathy
Rs53576 - GG (at least I have a good heart)

Blonde Hair
rs12821256 - TT
rs1667394 - TT
rs12896399 - GG

Wog?

I did that heredity report on frieger.com and it says that I have(had) a 55% chance of being blond and 45% chance of being black haired (I'm the latter). Children have a 40% chance of being blond and 32% of being black haired. I'd say that there's a 100% chance of being black haired unless their mother is a blonde.

This thing works. It shows the correct eye color, blood type, etc.

Ehhhh it looks like your carrier for the blonde allele as well. :p

Looks good so far!

[firemonkey]

Rs4778241-
(A;A) usually brown eye color
(A;C) usually brown eye color
(C;C) blue eye color if part of blue eye color haplotype

I am brown/hazel eyed


Rs363050

Geno Mag Summary
(A;A) 1.1 2.84 PIQ points higher than AG genotype
(A;G) 1.1 2.8 PIQ points higher than GG genotype
(G;G) 0.1 2.8 PIQ points lower than AG genotype

This makes sense as I know my PIQ to be much lower than my VIQ.


RS 53576- (A;A) 2.8 Lack of empathy?
(A;G) 2.8 Lack of empathy?
(G;G) 2.5 Optimistic and empathetic; handle stress well

I don't see myself as lacking empathy, but I don't handle stress well.

[gültekin]

http://www.snpedia.com/index.php/Promethease
^^ this tool gives me the most important answer for a man's life :)
Rs2073963
http://www.snpedia.com/index.php/Rs2073963

[Highlands]

Eye Color.
Rs4778241 - CC
I have light eyes so this is accurate so far.

Skin Color.
Rs1426654 - AA
I have pale white skin but I tan easily. It's not "celtic" pale but a shade darker. 6–8 on Von Luschan's scale.

Intelligence/Cognitive Decline
rs821616 - AA
Good news for me I guess.

Intelligence
Rs363050 - AG
Meh.

Empathy
Rs53576 - GG
I'm empathetic towards those who deserve it. I'm not that good at handling stress.

Blonde Hair
rs12821256 - TT
rs1667394 - TT
rs12896399 - GT

I have brown hair but I have some relatives with blonde hair from my mother's side. My family is pred. brunette.

[Petalpusher]

Can you even combine blonde and intelligence


Eye Color.
Rs4778241 - AC


Skin Color.
Rs1426654 - AA


Intelligence/Cognitive Decline
rs821616 - AA


Intelligence
Rs363050 - AA


Empathy
Rs53576 - AG


Blonde Hair
rs12821256 - TT
rs1667394 - CT
rs12896399 - GG

[de Burgh II]

http://www.snpedia.com/index.php/Promethease
^^ this tool gives me the most important answer for a man's life :)
Rs2073963
http://www.snpedia.com/index.php/Rs2073963

Best of luck! :thumb001:

[de Burgh II]

Can you even combine blonde and intelligence


Eye Color.
Rs4778241 - AC


Skin Color.
Rs1426654 - AA


Intelligence/Cognitive Decline
rs821616 - AA


Intelligence
Rs363050 - AA


Empathy
Rs53576 - AG


Blonde Hair
rs12821256 - TT
rs1667394 - CT
rs12896399 - GG

:lol:

[de Burgh II]

*Update*

Hair disposition:

SNP: Rs11803731

Gene: Trichohyalin gene (TCHH)

Description:
rs11803731, a SNP in the Trichohyalin gene (TCHH) gene, is estimated to account for 6% of the variance in hair morphology (ie hair curliness) based on a study of Australians of European ancestry.[PMID 19896111 ][PMID 20585627 ] Web-based, participant-driven studies yield novel genetic associations for common traits.

Genotype possibility:
AA = straighter hair
TT = curlier hair

Info: http://www.snpedia.com/index.php/Rs11803731

[Petalpusher]

TCHH 152083325 rs11803731 A or T AT

[de Burgh II]

TCHH 152083325 rs11803731 A or T AT

My hypothesis for being heterozygous for it is more leaning towards the wavy-straight threshold since this is one SNP identified associated with caucasoid phenotypic hair variation(s) since I noticed straight hair can turn wavy/curly when its very humid out. Nonetheless, from what I heard if one could find 4 to 5 SNPs in total then a person could give a good probable estimate of the genotypes on each identify gene to show what one will phenotypically express. I'm on the same boat since I have "AT" as well. :lol:

[Petalpusher]

Mine are straight as f when short, then get a little wavy when longer. So i think AT is more wavy than curly.

[de Burgh II]

Mine are straight as f when short, then get a little wavy when longer, but not wet. So i think AT is more wavy than curly.

Its quite interesting how wondrously intricate genetics can be, eh? :lol:

Very interesting nonetheless. Thank you for sharing! :thumb001:

[Petalpusher]

Im sure in about 10 years we ll be able to build an accurate photokit just with SNP's, it's already possible to some extent.

[de Burgh II]

*Update*

Another SNP for Hair variation:

SNP: Rs7349332

Gene: WNT10A

Possible Genotypes:
CC = straighter hair

TT = hair curl

My Genotype: CC

Article/findings: http://www.snpedia.com/index.php/Rs7349332

[Petalpusher]

WNT10A 219756383 rs7349332 C or T CC

CC as well.

[de Burgh II]

Im sure in about 10 years we ll be able to build an accurate photokit just with SNP's, it's already possible to some extent.

Very true! :thumb001:

Especially when they sequenced the entire human genome for a little while now so were slowly getting there gradually. :thumb001:

[de Burgh II]

Red Hair SNPs:

SNP “Red Hair” Version Alternate Name For Mutation
rs34474212 C S83P
rs1805006 A D84E
rs11547464 A R142H
rs1110400 C I155T
rs1805007 T R151C
rs1805008 T R160W
i3002507 C D294H


Ex: My Genotype (s):

SNP
rs34474212 N/A
rs1805006 CC
rs11547464 GG
rs1110400 TT
rs1805007 CC
rs1805008 TT
i3002507 GG





Redheads might have a better excuse than the rest of us for avoiding the dentist.

For several years now scientists have known that the same genetic variations that give redheads their fiery manes can increase the amount of general or local anesthetic a person needs in order to be properly put out or numbed up.

New research suggests that the effect of these variations is strong enough, and hasn’t been addressed by dentists well enough, that the people who carry them are more than twice as likely as those who don’t to avoid going to the dentist altogether.


Researchers at the University of Kentucky surveyed 67 redheads and 77 dark haired people about their general anxiety levels, their dental treatment-related anxiety and their fear of dental pain. The results, published in the July issue of the Journal of the American Dental Association, reveal that while hair color has no effect on general anxiety, redheads are more likely to be apprehensive about sliding into the dentist’s chair.

A closer look at the data showed that increased dental-treatment anxiety and fear of dental pain is found in all people with the variants in the MC1R gene associated with red hair, even those people who carry these variations despite having dark hair.

The protein encoded by the MC1R gene is found in melanocytes, the cells that give hair and skin their color. The variants associated with red hair alter the protein’s function, tipping the balance of pigment production in melanocytes from black-brown eumelanin to red-yellow pheomelanin. Researchers don’t yet understand how this same protein impacts pain sensitivity and anesthetic needs.

People carrying one or two of the MC1R variants had 2.46 times greater odds of avoiding routine dental care compared to those who carry none. The authors speculate that this might be because prior dental experiences have left them in pain.

(23andMe customers can use the table at the end of this post to see if they carry any of the MC1R variants associated with dental treatment-related anxiety, fear of dental pain and avoidance of dental treatment.)

The researchers recommend that dentists evaluate all patients, especially those with natural red hair, for dental procedure-related anxiety and take whatever steps are necessary to help them manage their feelings and make it to their regular check-ups, because as the saying goes, “Ignore your teeth and they’ll go away.”

http://blog.23andme.com/news/snpwatch-researchers-find-link-between-red-hair-and-avoiding-the-dentist/

[Zmey Gorynych]

Hair disposition:

SNP: Rs11803731
Genotype possibility:
AA = straighter hair
TT = curlier hair

My genotype is AA. Yeah, my hair is as straight as it gets.


SNP: Rs7349332

Possible Genotypes:
CC = straighter hair
TT = hair curl

My genotype is CC.


Red Hair SNPs:

SNP “Red Hair” Version Alternate Name For Mutation
rs34474212 C S83P
rs1805006 A D84E
rs11547464 A R142H
rs1110400 C I155T
rs1805007 T R151C
rs1805008 T R160W
i3002507 C D294H


My genotype:
rs1805006 - CC
rs11547464 - GG
rs1110400 - TT
rs1805007 - CC
rs1805008 - CC
i3002507 - GG

[Journeyman26]

Rs4778241: CC ... I have brown eyes though, so must be getting melanin somewhere else. On GEDmatch "eye color predictor" it predicts my eyes being bright blue lol... nope. My dad has blue eyes though.
Rs1426654: AA ... fair enough
Rs53576: GG... I guess I am fairly empathic
Rs11803731: AT... straight hair
Rs7349332: CC... straight hair

[Era]

rs11803731 A or T AA


rs7349332 C or T CC

This is surprising. My hair is kinda wavy.

[Zmey Gorynych]

Muscle Performance
Rs1815739

This SNP, in the ACTN3 gene, encodes a premature stop codon in a muscle protein called alpha-actinin-3. The polymorphism alters position 577 of the alpha-actinin-3 protein.
In the (C;C) genotype is often called RR. The truncated (T;T) is often called XX.

(T;T) is under-represented in elite strength athletes, consistent with previous reports indicating that alpha-actinin-3 deficiency appears to impair muscle performance.

Possible Genotypes:
CC - Better performing muscles. Likely sprinter.
CT - Mix of muscle types. Likely sprinter.
TT - Impaired muscle performance. Likely endurance athlete.

http://www.snpedia.com/index.php/Rs1815739

My genotype is CT

[Zmey Gorynych]

Rhesus factor
i4001527

Possible genotypes:
II - Rh positive
DI - Rh positive
DD - Rh negative

My genotype is DD which is correct, I'm Rh negative.

Haven't found snps for blood types yet.

Blood type O
Rs505922

Possible genotypes:
CC - not O
CT - not O
TT - blood type O

My genotype is TT, correct.

[Era]

Rhesus factor
[.

Haven't found snps for blood types yet.

This shows you your blood type. I remember there's also a snp for that cause they both showed me O but i cant find it now


I would highly recommend this heredity calculator since its quite accurate. I always thought I was predominantly black haired, but supposedly it shares a co-dominance with blonde hair. All you have to do is insert your raw data and let it rip! :thumbs up

http://dna.frieger.com/calc-heredity.php

I'm RH positive apparently, DI. Thanks for bringing that here

[Era]

wohooo, move over Linebacker, I should be a sprinter, too bad I dont have the disposition for it :D I can see that I get muscles with slight physical activity esp swimming



rs1815739 C or T CC

I <3 this thread!

[de Burgh II]

Rhesus factor
i4001527

Possible genotypes:
II - Rh positive
DI - Rh positive
DD - Rh negative

My genotype is DD which is correct, I'm Rh negative.

Haven't found snps for blood types yet.

Blood type O
Rs505922

Possible genotypes:
CC - not O
CT - not O
TT - blood type O

My genotype is TT, correct.

DI here as well as TT (Blood type O).


Muscle Performance
Rs1815739

This SNP, in the ACTN3 gene, encodes a premature stop codon in a muscle protein called alpha-actinin-3. The polymorphism alters position 577 of the alpha-actinin-3 protein.
In the (C;C) genotype is often called RR. The truncated (T;T) is often called XX.

(T;T) is under-represented in elite strength athletes, consistent with previous reports indicating that alpha-actinin-3 deficiency appears to impair muscle performance.

Possible Genotypes:
CC - Better performing muscles. Likely sprinter.
CT - Mix of muscle types. Likely sprinter.
TT - Impaired muscle performance. Likely endurance athlete.

http://www.snpedia.com/index.php/Rs1815739

My genotype is CT

Same as you here as CT; very interesting! :thumb001:

[Gooding]

I used this link: http://dna.frieger.com/calc-heredity.php. I was surprised at its accuracy.

Alcohol Flush Reaction:
Little or no flushing

rs671:GG

Little or no flushing

rs671:GG

Little or no flushing

Bitter Taste Perception
?
80%

Cannot taste

20%

Can taste
rs713598:CC

80%

Cannot taste

20%

Can taste
rs713598:CC

80%

Cannot taste

20%

Can taste

Blood Type (ABO)
?
Group O

rs8176719:DD

rs8176746:GG

rs8176747:CC

Click to hide genotype
Group O

Click to see genotype

Group O

Breast size
?

Average cup size:C

Not Applicable

Click to see genotype

Not Applicable

Click to see genotype

Not Applicable

Adjusted: C-D

[
B-C
-
C-D
]
6 out of 7 markers used

Caffeine Consumption
?

Average: 280 mg/day

Adjusted: 336 mg/day (+19.9%)

rs4410790:CC
+21.42

rs2470893:CT
+12.43

rs2472297:CT
+7.06

rs6968865:TT
+7.43
*
rs6495122:CC
+4.73


rs382140:GG
+2.56

Click to hide genotype
Adjusted: 336 mg/day (+19.9%)

Click to see genotype

Adjusted: 336 mg/day (+19.9%)

[
310 mg/day
-
361 mg/day
]
Cholesterol, HDL
?

Average: 55 mg/dL

Adjusted: 49 mg/dL (-10.3%)

31 out of 43 markers used

rs1042034:TT
-0.4

rs11869286:CG
-0.16
*
rs12328675:TT
-0.18
*
rs12678919:AA
-0.54

rs12967135:AG
-0.23
*

rs13107325:CC
+0.12

rs1532085:GG
-1.13

rs1689800:??

rs16942887:AG
+0.97
*
rs17145738:CC
-0.14
rs174546 :??

rs1800775:AC
+0.06

rs1800961:CC
+0.11

rs1864163:??

rs1883025:CT
-0.47


rs2293889:??

rs2652834:??

rs2814944:??

rs2925979:CT
-0.18

rs2954029:AT
+0.07
*

rs2972146:GT
+0.12
*
rs3136441:TT
-0.23
*
rs3764261:CC
-2.15

rs386000:CC
+1.33
*
rs4129767:AG
-0.02


rs4148008:CG
-0.15
*
rs4149268:CT
-0.23

rs4420638:AG
-0.7

rs4660293:AG
-0.26

rs4731702:CC
-0.57


rs4759375:CC
-0.1
*
rs4765127:GG
-0.3
*
rs4775041:??

rs4846914:AG
-0.12

rs581080:??


rs6065906:??

rs7134594:CT
-0.03

rs7241918:??

rs737337:TT
+0.1

rs838880:??


rs964184:CC
+0.39

rs9987289:??

rs9989419:AG
-0.64

Click to hide genotype
Adjusted: 49 mg/dL (-10.3%)

31 out of 43 markers used

Click to see genotype
Adjusted: 49 mg/dL (-10.3%)

[
35 mg/dL
-
64 mg/dL
]
31 out of 43 markers used

Cholesterol, LDL
?
Average: 115 mg/dL

Adjusted: 133 mg/dL (+15.3%)

29 out of 39 markers used

rs10401969:??

rs11065987:GG
-1.13

rs11136341:??

rs11206510:TT
+1.16

rs11220462:AG
+1.4
*

rs1169288:AC
+0.48

rs12027135:TT
+1.03
*
rs12670798:CC
+1.94

rs12916:TT
-1.91

rs1367117:AG
+1.62


rs1564348:CT
+1.29

rs16996148:GG
+0.73

rs174546:CC
+1.2

rs1800562:GG
+0.27

rs2000999:AG
+1.2
rs2072183:??

rs2081687:CC
-0.66
*
rs2131925:GT
-0.57
*
rs2255141:??

rs2479409:AG
+0.8


rs2642442:TT
-1.48
*
rs2954029:AT
-0.15
*
rs3177928:??

rs3757354:CC
+0.63

rs3764261:CC
+0.93


rs4299376:TT
-1.65

rs4420638:AG
+4.71

rs514230:AT
-0.05
*
rs562338:GG
+1.76
*
rs6029526:??


rs629301:TT
+2.49
*
rs635634:??

rs6511720:GG
+1.54

rs6882076:CT
-0.5
*
rs7206971:??


rs8017377:AA
+1.22

rs9488822:??

rs964184:CC
-0.74

rs9987289:??

Click to hide genotype
Adjusted: 133 mg/dL (+15.3%)

29 out of 39 markers used

Click to see genotype

Adjusted: 133 mg/dL (+15.3%)

[
106 mg/dL
-
159 mg/dL
]
29 out of 39 markers used

Cholesterol, Total
?
Average: 210 mg/dL

Adjusted: 212 mg/dL (+0.9%)

34 out of 46 markers used

Click to see genotype

Adjusted: 212 mg/dL (+0.9%)

34 out of 46 markers used

Click to see genotype


Adjusted: 212 mg/dL (+0.9%)

[
174 mg/dL
-
250 mg/dL
]
34 out of 46 markers used

Triglycerides
?

Average: 144 mg/dL
Adjusted: 132 mg/dL (-8.5%)

19 out of 26 markers used

Click to see genotype
Adjusted: 132 mg/dL (-8.5%)

19 out of 26 markers used

Click to see genotype


Adjusted: 132 mg/dL (-8.5%)

[
99 mg/dL
-
164 mg/dL
]
19 out of 26 markers used

Cleft Lip/Palate
?

Population average: 0.1%

Adjusted Risk: 0.2% (x1.3)

Click to see genotype

Adjusted Risk: 0.2% (x1.3)

Click to see genotype

Adjusted Risk: 0.2% (x1.39)
[
0.1%
-
0.4%
]
Earwax type
Wet ear wax

rs17822931:CT

Wet ear wax

rs17822931:CT

75%

Wet ear wax

25%

Dry ear wax

Eye color
?
Blue/Gray eyes

rs12913832:GG

rs1800407:CC

rs12896399:GT

rs16891982:GG

rs1393350:AG


rs12203592:CC

Click to hide genotype

Blue/Gray eyes

Click to see genotype

70%

Blue/Gray eyes

21%

Brown/Black eyes

9%

Green/Hazel eyes

Hair color
?

76%

Blond

24%

Light Red

rs11547464:GG

rs885479:GG

rs1805005:GG

rs1805006:CC

rs1805007:CT


rs1805008:CT

rs1805009:GG*

rs2228479:GG

rs1110400:TT

rs28777:AA


rs16891982:GG

rs12821256:CT

rs4959270:AA

rs12203592:CC

rs1042602:CC


rs1800407:CC

rs2402130:AA

rs12913832:GG

rs2378249:AA

rs683:AC

Click to hide genotype

76%

Blond


24%

Light Red

Click to see genotype

68%

Blond

22%

Light Red

10%

Light Brown

Lactose intolerance
?
Likely tolerant
rs4988235:AA

Likely tolerant

rs4988235:AA

Likely tolerant

Male Pattern Baldness
?

Average Lifetime Risk: 50% Men

Adjusted Risk: 19.8% (x0.4)

7 out of 8 markers used

Click to see genotype


Adjusted Risk: 19.8% (x0.4)

7 out of 8 markers used

Click to see genotype

Adjusted Risk: 21.7% (x0.43)

[
7.1%
-
55.1%
]
7 out of 8 markers used

Not Applicable

Spot baldness
?

Average Lifetime Risk: 1.7%

Adjusted Risk: 2.2% (x1.27)

Click to see genotype

Adjusted Risk: 2.2% (x1.27)

Click to see genotype

Adjusted Risk: 2.7% (x1.58)

[
0.5%
-
9.7%
]
Resting heart rate
?

Average: 67 bpm

Adjusted: 68 bpm (+1%)

Click to see genotype

Adjusted: 68 bpm (+1%)

Click to see genotype


Adjusted: 68 bpm (+1%)

[
69 bpm
-
66 bpm
]
Smoking Behavior
?

Average: 14 cigarettes/day

Adjusted: 15 cigarettes/day (+8.4%)

2 out of 3 markers used

Click to see genotype


Adjusted: 15 cigarettes/day (+8.4%)

2 out of 3 markers used

Click to see genotype

Adjusted: 15 cigarettes/day (+8.4%)

[
15 cigarettes/day
-
16 cigarettes/day
]
2 out of 3 markers used

Tanning Ability
Adjusted: Average-Light Tan

4 out of 5 markers used
rs10831496:??

rs11648785:CC
+0.07

rs12210050:CC
-0.02

rs1393350:AG
+0.15

rs35391:CC
+0.28

Click to hide genotype
Adjusted: Average-Light Tan

4 out of 5 markers used

Click to see genotype

Adjusted: Average-Light Tan

4 out of 5 markers used


Resistance and Immunity


Inheritable diseases

Cancer Risks

Cardiovascular diseases

Other diseases risks

[de Burgh II]

rs11803731 A or T AA


rs7349332 C or T CC

This is surprising. My hair is kinda wavy.

Hopefully there will be more genes identified since it is relatively understudied in terms of European here whereas there was more emphasis on studies on Asian hair straightness that may have evolved independently do to some similarities.


Four highly correlated single-nucleotide polymorphisms (SNPs) (rs17646946, rs11803731, rs4845418, rs12130862; r2 > 0.8, D′ > 0.95 within the HapMap CEU sample) on chromosome 1q21.3 (Figure 1B) reached our genome-wide significance threshold of 5 × 10−8, which corrects for ∼1 million independent common variants in the genome11 (Table 3, Figure S4). [...]

Which I found decent information about here in this study: http://www.sciencedirect.com/science/article/pii/S0002929709004649

[de Burgh II]

I used this link: http://dna.frieger.com/calc-heredity.php. I was surprised at its accuracy.

Probably one of the most accurate website/calculators that I can agree upon out there; couldn't find any other website that could do it via one's raw genetic data. :thumb001:

[Zmey Gorynych]

This shows you your blood type. I remember there's also a snp for that cause they both showed me O but i cant find it now
Frieger (heredity report) uses 3 other snps (at least for blood type O) to determine blood type, so that snp that I posted for blood type O might not be entirely accurate.

[Gooding]

Probably one of the most accurate website/calculators that I can agree upon out there; couldn't find any other website that could do it via one's raw genetic data. :thumb001:

I'll be honest with you, when I smoked, I did at least a pack a day. The fact remains that my hair does have reddish highlights while being blonde to a large degree and that's reflected in my SNPs as well. I don't understand all those letters and numbers, but when it was explained in plain and simple English, it was the easiest thing in the world for me to do to say " that's me."

[de Burgh II]

Metabolic Management:

Simply put: Lipid metabolism refers to the processes that involve the intercourse and degradation of lipids (fatty acids)

https://en.wikipedia.org/wiki/Lipid_metabolism

Info:
rs1801282, also known as Pro12Ala, is a common SNP in the peroxisome proliferator-activated receptor PPARG gene. The more common (C) allele (in dbSNP orientation) encodes the 'Pro' amino acid at this SNP position.
rs1801282 has been reported to be associated with metabolic syndrome, but other studies have not been able to replicate any strong or significant effect. [PMID 18959602]

[PMID 17554300OA-icon.png] The association between type-2 diabetes and SNP rs1801282 is mentioned as being replicated in

[PMID 18280041] rs1801282 and risk of cognitive decline in elders? Maybe with diabetes.

[PMID 19228871OA-icon.png] A ten-year study of 679 male patients with symptomatic coronary artery disease found that rs1801282(G) carriers had a much lower (10 year) cardiovascular risk, with the hazard ratio estimated to be 0.10 (CI: 0.01-0.70, p = 0.02) for ischemic heart disease and 0.24 for vascular death (CI: 0.08-0.74, p = 0.013) per copy of the allele.

23andMe blog carriers could be informed that they really need to watch out for high fat in their diets

Genotype possibilities:


Geno Summary
(CC) = normal fat metabolism; common in clinvar
(CG) = watch out for high fat in diet
(GG) = watch out for high fat in diet

My genotype: CC

More info: http://www.snpedia.com/index.php/Rs1801282

[de Burgh II]

I used this link: http://dna.frieger.com/calc-heredity.php. I was surprised at its accuracy.

The calculator that is operated by the geneticist utilizes 4 to 6 SNPs for each component to articulate its accurately via genetic studies out there that has identified selected genes as well as it SNPs to identify said topic.

[Gooding]

The calculator that is operated by the geneticist utilizes 4 to 6 SNPs for each component to articulate its accurately via genetic studies out there that has identified selected genes as well as it SNPs to identify said topic.

Awesome!:thumb001: Say what??

[de Burgh II]

Awesome!:thumb001: Say what??

Basically whatever they study (so say they study diabetes risk) they identify certain gene(s) that collectively play a role by identifying multiple SNPs (Single Nucleotide Polymorphisms) that act as genetic markers to associated with said genes; think of SNPs as a barcode you have when you buy groceries when it comes to identifying genes.

[Era]

Metabolic Management:

[/URL]

Damn it Armstrong I cant stay here all day long, CC but this doesnt surprise me :)

[Gooding]

I PHPed my previous post. How to spoiler it, I have no idea. I crossed my fingers when I PHPed it.

[de Burgh II]

Damn it Armstrong I cant stay here all day long, CC but this doesnt surprise me :)

Pretty soon you can say you have superior genes within your physique/genetic makeup that exceeds linebacker's in that regard. lol! :p

[de Burgh II]

I PHPed my previous post. How to spoiler it, I have no idea. I crossed my fingers when I PHPed it.

I don't think I'm familiar with this acronym.

[Gooding]

I don't think I'm familiar with this acronym.

It's a function of the Go Advanced edit feature. Wrap the text around with PHP.. it seems to minimize the text.

[Era]

Pretty soon you can say you have superior genes within your physique/genetic makeup that exceeds linebacker's in that regard. lol! :p

I wish, I had a pretty lousy one for bone strength, especially forearms

[de Burgh II]

I wish, I had a pretty lousy one for bone strength, especially forearms

I would say good products to balance out one's calcium intake would be yogurt, milk, cheese in moderate quantities, eggs, salmon, spinach, nuts, certain cereals like Kashi, tuna, etc. for any alternative to boost one's iron/calcium levels in one's bones. :thumb001:

[de Burgh II]

IF only they had SNPs available for one's circadian rhythm (internal biological clock) since it would be a very interesting topic:

"Larks" and "Owls": The Genetics of Circadian Rhythms
Humans are a diurnal species, meaning that we are generally active during the day and sleep at night. Some individuals feel more awake, alert, and able to do their best work in the morning. We typically refer to these people as "larks," or morning-type individuals. Others have a hard time waking up or feeling alert in the morning and feel that they are most productive in the evening or night. We refer to these people as "owls," or evening-type people.

i_genetics3.jpg
Being a morning or a night person is influenced by how fast or slow our internal clocks tick.

What determines our desire to wake with the sun or, conversely, burn the midnight oil, is influenced by the same system that regulates the cycling of many bodily functions. Our internal biological clock resides in the brain and regulates the timing of functions such as appetite, hormone release, and metabolism. Of all the cycles controlled by the circadian system, perhaps the most obvious is the sleep-wake cycle—when we go to sleep and when we wake up.

Although our internal clock is set to approximately 24 hours, the exact timing of circadian rhythms varies from one person to the next. Differences in the speed of the circadian clock may help determine whether you are an "owl' or a "lark." For instance, there is some evidence that if your circadian clock runs faster than 24 hours, you may tend to be a "lark"; if your clock runs slower than 24 hours, you tend to be an "owl."

Although we often use the term "morning person" in fun, being a morning or night person is influenced by the genetics of how fast or slow our internal clocks tick. Genes influence how fast or slow our internal clock runs and, as a result, how closely it—and our body’s functions—align with the 24-hour day. Changes in these genes, known as mutations, from one generation to the next can affect the clock's timing. For example, this can cause a child to have a faster or slower clock than his or her parents.

http://healthysleep.med.harvard.edu/healthy/science/variations/individual-variation-genetics

[de Burgh II]

After some searching around I have identified a SNP associated with height:

SNP: Rs1042725

Description:
nature SNP rs1042725 is associated with height (P = 4E-8) in a study involving over 20,000 individuals. The gene harboring this SNP, HMGA2, is a strong biological candidate for having an influence on height, since rare, severe mutations in this gene are known to alter body size in mice and humans.
rs1042725 is estimated to explain approx 0.3% of population variation in height in both adults and children (approx 0.4 cm increased adult height per C allele).

Genotype possbilities:

Geno Summary
(CC) = ~0.8cm taller
(CT) = ~0.4cm taller
(TT) = Average height

MY genotype: CT

Info: http://www.snpedia.com/index.php/Rs1042725

[Era]

After some searching around I have identified a SNP associated with height:

SNP: Rs1042725

Description:

Genotype possbilities:

Geno Summary
(CC) = ~0.8cm taller
(CT) = ~0.4cm taller
(TT) = Average height

MY genotype: CT

Info: http://www.snpedia.com/index.php/Rs1042725


Mine too, CT

CT for the one below too

[de Burgh II]

Another for height:

SNP: Rs6060369

Info:
rs6060369 is a SNP associated with a (slight) increase in height, in that individuals tend to be 0.44cm taller for each rs6060369(C) allele they carry. This finding was statistically significant (p=9.7x10e-7), and ultimately tested in over 28,000 individuals.[PMID 18193045OA-icon.png]
A haplotype of rs6060369 and rs143383, a neighboring SNP in the GDF5 gene, can be defined, which also links height to osteoarthritis since rs143383 has previously been linked to osteoarthritis.[PMID 18193045OA-icon.png]

Genotype possibilities:

CC = 0.88 cm taller
CT = 0.44 cm taller
TT = Normal height

CT again

More info: http://www.snpedia.com/index.php/Rs6060369

Study it came from: https://fusion.sph.umich.edu/Pubs/papers/lettre_height_2008.pdf

[de Burgh II]

Mine too, CT

Nice! :thumb001:

[de Burgh II]

Two more SNPs for height:
Rs9834312


rs9834312 is a SNP in the filamin B, beta (actin binding protein 278) FLNB gene.
Based on a study of 1,000+ Caucasians and 2,000+ Chinese, rs9834312 was associated with height in both Caucasian populations (p=0.008) and Chinese populations (p=0.017)

Genotype possibilities:

Geno Summary
(A;A) normal
(A;G) None
(G;G) taller

AA

Info: http://www.snpedia.com/index.php/Rs9834312

Rs6060369


rs6060369 is a SNP associated with a (slight) increase in height, in that individuals tend to be 0.44cm taller for each rs6060369(C) allele they carry. This finding was statistically significant (p=9.7x10e-7), and ultimately tested in over 28,000 individuals.[PMID 18193045OA-icon.png]
A haplotype of rs6060369 and rs143383, a neighboring SNP in the GDF5 gene, can be defined, which also links height to osteoarthritis since rs143383 has previously been linked to osteoarthritis.[PMID 18193045OA-icon.png]

Genotype possibilities:
Geno Summary
(C;C) 0.88cm taller
(C;T) 0.44cm taller
(T;T) normal height

CT

More info: http://www.snpedia.com/index.php/Rs6060369

[Era]

Two more SNPs for height:
Rs9834312



Genotype possibilities:

Geno Summary
(A;A) normal
(A;G) None
(G;G) taller

AA

Info: http://www.snpedia.com/index.php/Rs9834312

Rs6060369



Genotype possibilities:
Geno Summary
(C;C) 0.88cm taller
(C;T) 0.44cm taller
(T;T) normal height

CT

More info: http://www.snpedia.com/index.php/Rs6060369

I should be taller according to these, I was a lazy kid though



rs9834312 A or G GG


rs6060369 C or T CT

[de Burgh II]

I should be taller according to these, I was a lazy kid though



rs9834312 A or G GG


rs6060369 C or T CT

Its quite true the height has a strong heredity component overall, but it also takes in account of nutritional influences to an extent. Nonetheless, heredity will almost always have a stronger influence due to the interactions of the encoded genes with height. :thumb001:

[Era]

Its quite true the height has a strong heredity component overall, but it also takes in account of nutritional influences to an extent. Nonetheless, heredity will almost always have a stronger influence due to the interactions of the encoded genes with height. :thumb001:

I am still taller than most girls I see daily at 5.5. Especially millenials (girls mostly) seem to be shorter than people older then them. I was well fed by the way so it's not nutritional.

[de Burgh II]

I am still taller than most girls I see daily at 5.5. Especially millenials (girls mostly) seem to be shorter than people older then them.

I guess when it boils down to it, people are simply a byproduct of their genes as well as environment. Perhaps it depends on these intricate interactions overall. I've seen women who were over +6' tall that could tower over some men including myself. It depends if the individual gets the "genetic lottery" or not.

[de Burgh II]

This is one thing I'm curious about since weirdly enough I have an immunity to it.

Immunity against the Norovirus:


rs601338 is found on chromosome 19 in the alpha(1,2)-fucosyltransferase FUT2 gene. The wild-type rs601338(G) encodes the "secretor" (Se) allele, while rs601338(A) encodes the "non-secretor" (se) allele.
A study of 115 Swedish adults concluded that rs601338(A;A) homozygotes have genetic immunity to infection by the Norwalk norovirus, a major (and contagious) cause of acute gastroenteritis worldwide among adults. [PMID 12692541] [PMID 16306606OA-icon.png] This illness is also known as "cruise ship gastroenteritis."

Being a non-secretor may have other consequences, such as greater susceptibility to infection by influenza viruses and by some types of bacteria. 23andMe discusses these topics.

In some non-Caucasian populations, a different SNP is responsible for non-secretor phenotypes. For example, although the Se allele is absent in Japanese, 15% are non-secretors based on being homozygous for the non-secretor "sej" allele of SNP rs1047781. [PMID 8621666]

Rs601338

Possible genotypes:

Geno Summary
(AA) resistance to Norovirus infection
(AG) susceptible to Norovirus infections
(GG) susceptible to Norovirus infections

Info: http://www.snpedia.com/index.php/Rs601338

[Era]

This is one thing I'm curious about since weirdly enough I have an immunity to it.

Immunity against the Norovirus:



Rs601338

Possible genotypes:

Geno Summary
(AA) resistance to Norovirus infection
(AG) susceptible to Norovirus infections
(GG) susceptible to Norovirus infections

Info: http://www.snpedia.com/index.php/Rs601338

I was GG. What's that.

[de Burgh II]

I was GG. What's that.


Gastroenteritis, that was probably due to norovirus, was first described by Zahorsky in 1929 as ‘winter vomiting disease’. However the agent was not identified until 1972, when virus particles were first visualised by electron microscopy (EM) in faeces obtained from an outbreak. The outbreak had occurred in 1968 at a school in Norwalk, Ohio, US, with a high attack rate of illness among students and teachers. The illness was characterised by nausea, vomiting and diarrhoea with duration of illness of 12–24 hours [12].

In Australia, the first confirmed norovirus outbreak occurred in 1978 and was associated with oyster consumption [13]. The outbreak affected people across Australia, and norovirus was confirmed as the cause by visualisation of virus particles in patients’ faeces by EM and immuno-EM [13, 14]. This outbreak was one of the first recorded foodborne outbreaks of norovirus [13].

The discovery of the virus through EM was important because this was the first virus detected that was specifically associated with cases of acute gastroenteritis. For decades the role of the virus as a causative agent has been hampered by the insensitivity of microbiological diagnostics. It cannot be grown in cell culture and there is no small animal model. The only alternative is to test on human volunteers [12]. Since the 1970s, the viruses were known as ‘Norwalk-Like Viruses’ (NLV) and ‘Small Round Structured Viruses’ (SRSV). The early names of these viruses were determined by the location where each strain was detected (e.g. Hawaii, Norwalk) or by their physical appearance as visualised with EM [15, 16].

In 2002, norovirus became the official genus name, following further investigation of the viral taxonomy by sensitive molecular techniques. Improvement in diagnostic techniques has allowed for rapid recognition of the causative agent in outbreaks and has changed the understanding of the clinical significance and epidemiology of this virus [17].

Symptoms:Noroviruses cause an infection of the digestive tract which presents with acute onset of diarrhoea, abdominal cramps, nausea and vomiting. Vomiting is more common among children while a greater proportion of adults experience diarrhoea. Systemic symptoms such as fever, headache, myalgia, malaise and abdominal pain can also occur [24].

The median incubation period is classically 32 hours, with a range of 24–48 hours, but can extend outside this range (12–50 hours). Symptoms usually resolve within 24–48 hours but may range from 12–72 hours [25]. However, in some people symptoms can last longer than previously thought, particularly among the elderly and in young children, as well as among transplant recipients and the immunosuppressed, such as people on immunosuppressive therapy, or ill with immune-modulating diseases (e.g. HIV) [17, 26].

The illness is usually self-limiting (resolves without treatment) and recovery is complete without any serious long-term sequelae. However, more severe clinical disease can be seen in the elderly and those with other underlying disease, such as cardiovascular disease, renal transplant recipients and those on immunosuppressive therapy [17]. Severe complications can be seen in these settings, with decreased potassium levels, increased C-reactive protein and creatine phosphokinase [26]. Deaths may occur among ACF residents due to aspiration or exacerbation of other chronic diseases

http://www.health.gov.au/internet/publications/publishing.nsf/Content/cda-cdna-norovirus.htm-l~cda-cdna-norovirus.htm-l-2

[Zmey Gorynych]

Metabolic Management
rs1801282

I also got CC

Height
Rs1042725

My genotype is CC

Rs6060369

TT for this one

Rs9834312

AG for this one

Rs6060369

TT for this one

Mixed results. I'm 191cm/6ft3, so above average. Parents are pretty tall too for their generation.

Norovirus
Rs601338

AG - no immunity

Alcohol dependence
Rs1799971

The rs1799971(G) allele in exon 1 of the mu opioid receptor OPRM1 gene causes the normal amino acid at residue 40, *****agine (Asn), to be replaced by *****tic acid (Asp). In the literature this SNP is also known as A118G, N40D, or Asn40Asp.
Carriers of at least one rs1799971(G) allele appear to have stronger cravings for alcohol than carriers of two rs1799971(A) alleles, and are thus hypothesized to be more at higher risk for alcoholism.
http://www.snpedia.com/index.php/Rs1799971

Possible genotypes:

AA - normal
AG - stronger cravings for alcohol. if alcoholic, naltrexone treatment 2x more successful
GG - more pain

My genotype is AA

Rs1076560

rs1076560 is located in intron 6 of the dopamine receptor D2 gene.
In one study of Japanese males, rs1076560(A) alleles were 1.3 fold more associated with Alcoholism than the rs1076560(C) alleles.
The DRD2 risk allele A was more prevalent in the alcoholic patients than in the healthy controls. These data identify rs1076560 as a potentially important variable in the development of alcoholism.
http://www.snpedia.com/index.php/Rs1076560

Possible genotypes:
AA - influences working memory
AC - 1.3x increased risk for alcoholism
CC - normal

My genotype is CC

Rs2948694
This SNP in the growth hormone secretagogue receptor GHSR gene has been linked to heavy alcohol consumption in a study of 417 Spanish adults (so not exactly a big sample)

Possible genotypes:
AA - normal
AG - increased risk for heavy alcohol consumption
GG - increased risk for heavy alcohol consumption (twice biggee than AG)

My genotype is AA

Looks like I'm not prone to alcoholism.

[de Burgh II]

Body Mass Index/ body weight distribution:

SNP: Rs17817449


Within the FTO gene, many SNPs appear to be co-inherited. The SNP showing the strongest association with body weight (i.e. body mass index, BMI) is not rs17817449, although this SNP is one of co-inherited SNPs in the FTO gene region. For more information, refer to the FTO gene or the most studied of FTO SNPs, rs9930506. [PMID 17658951OA-icon.png]
[PMID 18316358] A study of 900+ Quebec individuals reported that rs17817449 was associated with BMI (p=0.0014), weight (p=0.0059) and waist circumference (p=0.0021) under an additive model, and in addition, influenced fasting insulin (p=0.011) and HOMA-IR (p=0.038).

http://www.snpedia.com/index.php/Rs17817449

Possible genotypes:

Geno Summary
(GG) ~1.7x increased obesity risk
(GT) ~1.3x increased obesity risk
(TT) normal

My genotype:
GT

[sql]

Have you tried Promethease?

[de Burgh II]

Have you tried Promethease?

Not yet; I'm going to assume it is a heredity report calculator that is similar to this?

http://dna.frieger.com/calc-personal.php

[Zmey Gorynych]

Body Mass Index/ body weight distribution:

SNP: Rs17817449
Same genotype: GT

[Petalpusher]

Body Mass Index/ body weight distribution:

SNP: Rs17817449

Geno Summary
(GG) ~1.7x increased obesity risk
(GT) ~1.3x increased obesity risk
(TT) normal


TT on this one.


Metabolic Management
rs1801282

CG


Height
Rs1042725

CT

[de Burgh II]

Neanderthal SNPs/ qualities

Rs6591536


rs6591536, also known as N183D or Asn183Asp, is a SNP in the olfactory receptor, family 5, subfamily A, member 1 OR5A1 gene. The rs6591536(A) allele encodes the *****agine (N).
Individuals vary in their ability to smell various odors, largely due to variations in their olfactory receptors. Carriers of one or two rs6591536(G) alleles can detect a particular compound, β-ionone, at levels two orders of magnitude lower than rs6591536(A;A) individuals. In fact, this study reports that 96% of the observed phenotypic variation is determined by this single SNP, making it nearly a completely Mendelian trait. People with high or low β-ionone sensitivity are found in all populations, and based on this SNP, variability was seen even in Neanderthal populations.[PMID 23910657]

Since rs6591536 determines β-ionone odor sensitivity, generally described as "floral", preferences may depend on genotypes at this SNP. The same study cited above found that on average, high-sensitivity individuals were more likely to prefer fragrances and household products containing β-ionone than low-sensitivity individuals, whereas when in food products such as beverages and chocolates, high-sensitivity individuals rated them lower than low-sensitivity individuals. In general, low-sensitivity individuals, i.e. rs6591536(A;A) individuals, were less likely to perceive the β-ionone for good (in scented household products) or for bad (in foods).[PMID 23910657]

β-ionone has anti-cancer properties[PMID 18386789], however it is unknown whether differences in β-ionone flavor sensitivity affect cancer risk by changing the amount of β-ionone people consume.

Possible genotypes:

Geno Summary
(AA) less able to detect β-ionone (floral) fragrance
(AG) more able to detect β-ionone (floral) fragrance
(GG) more able to detect β-ionone (floral) fragrance

http://www.snpedia.com/index.php/Rs6591536

My genotype: AG

Rs12416000

Possible genotypes:

Geno Summary
(AA) Neanderthal gene
(AG) mixed homo-sapiens (human) and Neanderthal
(GG) homo sapiens gene (not Neanderthal)

http://www.snpedia.com/index.php/Rs12416000

My genotype: AG

[de Burgh II]

Skin pigmentation

rs1426654


This SNP influences skin pigmentation. The allele, A111T, rs1426654(A), indicates light-skinned european ancestry. [PMID 16847698, PMID 16357253]
It appears as if this SNP is a relatively new one in human evolution; one estimate [PMID 17182896] is that the rs1426654(A) allele, in other words, light skin pigmentation, spread through the European population around 6,000 - 12,000 years ago. Prior to that, "European ancestors" were most likely relatively brown-skinned. Another study ([PMID 24048645OA-icon.png]) has concluded that almost individuals carrying the A111T variant can trace ancestry back to a single person who most likely lived at least 10,000 years ago.

This SNP is one of three from the SLC24A5 gene that can be analyzed to categorize the ancestry of a person as either European, African, or Asian, based on a 2009 study.[PMID 19440451OA-icon.png]:


Geno Mag Summary
(A;A) 2,7 probably light-skinned, European ancestry
(A;G) 2,5 mixed European + (African or Asian) ancestry possible
(G;G) 2,6 probably darker-skinned, Asian or African ancestry

AA

http://www.snpedia.com/index.php/Rs1426654


rs16891982

Geno Mag Summary
(C;C) 1.1 generally non-European, but if European, 7x more likely to have black hair
(C;G) 2 if European, 7x more likely to have black hair
(G;G) 1.1 Generally European; Light skin; Possibly an increased risk of melanoma

http://www.snpedia.com/index.php/Rs16891982

GG

rs1042602


PMID [PMID 17952075]
Trait Freckles
Title Genetic determinants of hair, eye and skin pigmentation in Europeans
Risk Allele C
P-val 1.9999999999999999E-11
Odds Ratio 1.32 [1.17-1.49]


Geno Mag Summary
(A;A) associated with the absence of freckles
(A;C) Carrier
(C;C) 0 Freckling

http://snpedia.com/index.php/Rs1042602

CC