XYY syndrome: Can it be detected by looks?

[Helloandgoodbye]

Hello!

I wonder if Gerwald Claus-Brunner, a German politician who stalked and murdered a young man, had this syndrome. He was 206 centimetres tall and had a violent temper.

[Peterski]

Probably not but it can be detected with any DNA test.

Even with commercial ones like FTDNA or 23andMe.

[de Burgh II]

It is a subsidiary grouping of the collective grouping of "trisomic disorders" or Trisomy 23 (XXY) if one wants to get technical. Also known as, "Klinefelter Syndrome." That is biologically male with some estrogenic influences due to the prevalence of the extra "X" chromosome.

Nevertheless, physiologically, can be quite perceptible to a trained eye reasoned in the practice to such phenotypical aberrations.

This condition was first identified by Dr. Harry Klinefelter at the Massachusetts General Hospital in Boston. A report published he and his coworkers reported case studies on nine men who had enlarged breasts, sparse facial and body hair and an inability to produce sperm.

Now more appropriately referred to as XXY Male of XXY Male Syndrome, males born with this condition have an extra sex chromosome XXY instead of the usual genotype XY. It is associated with a 47XXY karyotype and statistically occurs in 1/500 newborns.
Clinical features
Klinefelter is occasionally associated with lymphatic blockage or fetal hydrops and thus is included in a discussion of developmental disorders of the lymphatics.
Original symptoms included tall stature, long upper extremities, poor pubertal development, microorchidism, enlarged breasts, sparce facial and body hair, small testes and subsequent sterility.
Recent studies have expanded the original symptoms to include infertility, incomplete masculinization; feminine, or pear shaped, body and body hair distribution, decreased libido, osteoporosis, taurodontism, venous disease (which may include mitral valve prolapse, varicose veins and venous ulcers), learning and emotional disorders, autoimmune disorders, low energy and self esteem, communication difficulties, especially with expressive language, frustration-based outbursts, motor skills issue and developmental delays. Also, there is a 20 times increased risk for XXY males to develop breast cancer than non XXY males.
Treatment
For proper care and treatment early diagnosis is important. The treatment includes hormone therapy such as testosterone replacement. Other treatment aspects should include the psychosocial and emotional problems, needed treatment for physiological side affects and later on even genetic counseling.

https://trisomydisorders.wordpress.com/2008/10/30/trisomy-23/

A more covert, one that would be hard to detect would be Androgen Insensitivity Syndrome.


Androgen insensitivity syndrome is a condition that affects sexual development before birth and during puberty. People with this condition are genetically male, with one X chromosome and one Y chromosome in each cell. Because their bodies are unable to respond to certain male sex hormones (called androgens), they may have mostly female external sex characteristics or signs of both male and female sexual development.

Complete androgen insensitivity syndrome occurs when the body cannot use androgens at all. People with this form of the condition have the external sex characteristics of females, but do not have a uterus and therefore do not menstruate and are unable to conceive a child (infertile). They are typically raised as females and have a female gender identity. Affected individuals have male internal sex organs (testes) that are undescended, which means they are abnormally located in the pelvis or abdomen. Undescended testes have a small chance of becoming cancerous later in life if they are not surgically removed. People with complete androgen insensitivity syndrome also have sparse or absent hair in the pubic area and under the arms.

The partial and mild forms of androgen insensitivity syndrome result when the body's tissues are partially sensitive to the effects of androgens. People with partial androgen insensitivity (also called Reifenstein syndrome) can have genitalia that look typically female, genitalia that have both male and female characteristics, or genitalia that look typically male. They may be raised as males or as females and may have a male or a female gender identity. People with mild androgen insensitivity are born with male sex characteristics, but they are often infertile and tend to experience breast enlargement at puberty. [...]

https://ghr.nlm.nih.gov/condition/androgen-insensitivity-syndrome#genes

*Edit Read the Kartotype differently*

This Trisomic disorder (XYY) is indeed rare, to my knowledge might act as a "super-hormone" due to the excessive prevalence of testosterone of two Y chromosomes that effects the adrenal complex with over-emotionality, lowered IQ due to the high testosterone levels and lowered testes as a result.