Post your 23andme Dopamine (rs4680)

[War Chef]

rs4680

Two AA's at rs4680 = high dopamine
Two GG's at rs4680 = low dopamine
AG = intermediate

I am GG.


The Worrier (A)…Lower COMT, Higher Dopamine. (Met)

AA is considered the ‘risk’ or ‘bad’ allele in part because people don’t do well with stress and because lower COMT can create issues with methylation and not breaking down estrogen byproducts (catechol estrogens).

AA’s get more pleasure out of life but also more misery (bigger high’s and low’s).

The Good
•Gets more pleasure out of life – AA’s had twice the positive emotion towards a pleasant event than GG’s. GG people subjectively viewed a very pleasurable event on the same level that AA would view a slightly pleasurable event. (R) AG had a mid -level. Effect for this was “quite large”. (R)
•More Creative (divergent thinking fluency – more of an effect with other genes). Dopamine in the Prefrontal cortex promotes cognitive stability by being more resistant to distractions. (R)
•Higher IQ (tested in people with schizophrenia). (R)
•Better working memory. (R, R2) – during an N-back task and a go-no-go task there was increased activation in the right posterior cingulate cortex for healthy adults with AG and AA compared to GG. (R) Also better verbal working memory(letter-number sequencing) in AA and AG compared to GG. (R)
•Better reading comprehension (R)
•More plasticity in older age – better responses to N-back brain training. (R)
•Better cognitive function when not under stress: Better attention and processing of information (executive function). (R) However, realize that this one gene only accounts for 4% of the difference in executive function. The FAB exam tests executive function. GG scored an average of 16.0, GA 15.7 and AA 15.3. These scores are statistically significant, but not large. (R)
•More Exploratory (R)
•Have a better response to placebos. (R) – Dopamine is thought to link to reward and ‘confirmation bias’ which enhance the sense that the treatment is working. More prominent in studies with subjective conditions such as pain and fatigue rather than objective physiological measurements. The response of patients with AG fell in the middle.
•Higher cognitive stability? but comparatively low
cognitive flexibility. (R)
•Increased verbal fluency for males (but decreased it for females). (R)
•Better fine motor skills(AA vs GG) (control of small muscles in the fingers for grasping and manipulation). (R)
•Better ability to Aim. (R)
•AA’s focus more when they realize they have made an error. (R)
•Better absorption of tea polyphenols/EGCG. (R)
•AA’s had a lower risk for alcoholism. (R)
•AA’s had Better response to paxil/paroxetin. (R)

The Bad
•Worse handling of stress or pain. (R) Researchers found when viewing unpleasant pictures, the startle response of women with AA was about six times stronger compared to those with only one A or none at all. (R)
•Anxiety: Studies have correlated AA allele with OCD, panic disorder, phobic anxiety. (R, R2)
•Lower emotional resilience/more negative emotions/less able to handle negative events well.
•More impulsive (AA vs GG). (R) More significant in people who had AA for this gene AND TT for rs6313. (R)
•More depression – but relationship is complex. (R)
•Less Cooperative, Helpful and Empathic (AA, in females)(R)
•Less Extroverted (R)
•More neurotic (trended). (R)
•Higher Homocysteine – 10.4% in AA. (R)
•Higher risk of ADHD and ADHD severity (R)
•Higher sensitivity to mercury – boys (but not girls) with AA had impaired cognitive performance when exposed to mercury. (R)
•Fibromyalgia people with AA showed higher sensitivity to heat and pressure pain stimuli (R)
•It has also been linked with breast cancer risk — Asian-American women who have an AA or one A who also drink black or green tea appear to have a decreased chance of developing the disease. (R)
•44% Increased risk for cocaine dependence.
•boys with TT had worse cognitive performance when acutely exposed to mercury. (R)


The Warrior (G)…Higher COMT, Lower Dopamine (Val)

The Good
•Better handling of stress and pain. (R)
•Better at learning languages. (R)
•More Cooperative, Helpful and Empathic (GG, in females)(R)
•Higher emotional resilience/able to handle negative events well.
•Increased verbal fluency for females (also decreased for males). (R)
•Better working memory and higher hippocampal volume – in healthy chinese. (R) As you can see AA is not always smarter than GG and it depends on other factors.
•GG deprived of sleep responded well to modafinil in terms of improved vigor and well-being, and maintained baseline performance with respect to executive functioning. AA individuals barely responded to the drug at all. (R)
•Can more easily get into hypnosis. (R)
•GG results in more methylation in the gut (R).

The Bad
•Less pleasure out of life – AA’s had twice the positive emotion towards an event than GG’s. GG people subjectively viewed a very pleasurable event on the same level that AA would view a slightly pleasurable event. (R)
•Lower IQ (tested in people with schizophrenia) (R)
•Worse executive function/processing information, but better under stress. (R) However, realize that this one gene only accounts for not more than 4% of the difference in executive function. The FAB exam tests executive function. GG scored an average of 16.0, GA 15.7 and AA 15.3. These scores are statistically significant, but not large. (R)
•Worse fine motor skills (AA vs GG) (control of small muscles in the fingers for grasping and manipulation). (R)
•Less Exploratory. (R)
•More childhood depressive symptoms for GG. (R)
•2X Increased risk for breast cancer. (R)
•GG has 11X Higher risk of getting schizophreniform disorder from smoking pot as a teenager. AG has a 2.5X likelihood. (R) However, a later study did not find this. (R)


https://selfhacked.com/2014/12/24/worrier-warrior-explaining-rs4680comt-v158m-gene/

[Pahli]

I am AG lol

[War Chef]

Doing a line of coke right now to make up for my weak COMT system.....

BuMP

[The Illyrian Warrior]

GG, low dopamine, I score positive in two warrior genes.

[Era]

GG

[Era]

GG, low dopamine, I score positive in two warrior genes.

GG is also named as the warrior here, better equipped at handling stress ;)

The Warrior (G)…Higher COMT, Lower Dopamine (Val)

The Good
•Better handling of stress and pain. (R)
•Better at learning languages. (R)
•More Cooperative, Helpful and Empathic (GG, in females)(R)
•Higher emotional resilience/able to handle negative events well.
•Increased verbal fluency for females (also decreased for males). (R)

[Lek]

What a bunch of fucking broscience

[War Chef]

What a bunch of fucking broscience

Yeah yeah, whatever dumbass. Educate yourself before you have another bitch-fest.....

The COMT system is responsible for degradation of catecholamines (Dopamine, Norepinephrine etc.) It is written in neurology papers that people with two copies of AA have 300% more Dopamine than those with GG. GG people should in theory be addicted to coffee & need it to function, where if an AA person drinks coffee it brings about some sort of mania frenzy.

I suspect this is why Central Euro's (CEU) are such workaholics:

http://i.imgur.com/2ixhMZN.png

By the way, GG carriers respond well to something known as "modafinil" while AA don't respond at all (probably because they already have ample dopamine supply).

https://www.ncbi.nlm.nih.gov/pubmed/19037200?dopt=Abstract

[Era]

What a bunch of fucking broscience

Are you AA?

[Dick]

where do i find this on the new 23andme

[War Chef]

where do i find this on the new 23andme

They have a "browse raw data" snp search somewhere

[Era]

where do i find this on the new 23andme

Tools - browse raw data

[Dick]

http://i63.tinypic.com/24cvzte.jpg

[Ylla]

COMT rs4680 19951271 A or G G / G

[Lek]

Yeah yeah, whatever dumbass. Educate yourself before you have another bitch-fest.....

The COMT system is responsible for degradation of catecholamines (Dopamine, Norepinephrine etc.) It is written in neurology papers that people with two copies of AA have 300% more Dopamine than those with GG. GG people should in theory be addicted to coffee & need it to function, where if an AA person drinks coffee it brings about some sort of mania frenzy.

I suspect this is why Central Euro's (CEU) are such workaholics:

http://i.imgur.com/2ixhMZN.png

By the way, GG carriers respond well to something known as "modafinil" while AA don't respond at all (probably because they already have ample dopamine supply).

https://www.ncbi.nlm.nih.gov/pubmed/19037200?dopt=Abstract

Dude , you spit some of the biggest broscience ive ever seen.

East Europeans/South East like Albanians, Polaks and Lithuanians are by far some of the biggest workaholics ive ever met.

[Lek]

Are you AA?

How am I supposed to know?

Its a typical feminine trait to assume I am something because I dont agree with it or if i dont care about it. And you even see a lot of dudes on here display this feminine trait.

If i call women

[Era]

How am I supposed to know?



You can search your raw data :eek:

[War Chef]

Dude , you spit some of the biggest broscience ive ever seen.

East Europeans/South East like Albanians, Polaks and Lithuanians are by far some of the biggest workaholics ive ever met.

Work smarter, not harder.

[War Chef]

Somethings weird here. ... no AA or AG people on TA?

[Dick]

Work smarter, not harder.

make money work for you instead of working for it. invest in mutual funds.

[Peterski]

I get this:


Two AA's at rs4680 = high dopamine

http://i.imgur.com/J1rqpqz.png

I worry about all of you my TA friends all the time. :cry

[War Chef]

I get this:



http://i.imgur.com/J1rqpqz.png

I knew it. That's why I sent you PM..... your posting style is high energy/stamina

[War Chef]

make money work for you instead of working for it. invest in mutual funds.

Or....... get a degree in healthcare field and perv on hot nurses while getting paid ;)

[Dick]

Or....... get a degree in healthcare field and perv on hot nurses while getting paid ;)

:thumb001:

[Vyasa]

I am AA

[War Chef]

Btw Modafinil is epic. I recommend it for all my GG bros and sisters. ..

[Petalpusher]

GG


By the way CEU is not "Central Euro", it's white Utah Americans, mostly Anglo/German mixes.

[Sizzo]

A/G

[Dick]

GG


By the way CEU is not "Central Euro", it's white Utah Americans, mostly Anglo/German mixes.
http://media0.giphy.com/media/NcsWcNAPvh8T6/giphy.gif

[Petalpusher]

http://media0.giphy.com/media/NcsWcNAPvh8T6/giphy.gif

Totally agree

http://guyspeed.com/files/2016/06/girl-jogging-boobs-bouncing.gif

[Peterski]

Btw Modafinil is epic. I recommend it for all my GG bros and sisters. ..

What do you recommend for AAs? Or are we fine without taking anything?

[Peterski]

The COMT system is responsible for degradation of catecholamines (Dopamine, Norepinephrine etc.) It is written in neurology papers that people with two copies of AA have 300% more Dopamine than those with GG. GG people should in theory be addicted to coffee & need it to function, where if an AA person drinks coffee it brings about some sort of mania frenzy.

LOL, I usually drink 3-4 cups of coffee per day!

[Dick]

LOL, I drink 3-5 cups of coffee per day!

Drink decaf coffee.

[Peterski]

The Bad
•Worse handling of stress or pain. (R) Researchers found when viewing unpleasant pictures, the startle response of women with AA was about six times stronger compared to those with only one A or none at all. (R)
•Anxiety: Studies have correlated AA allele with OCD, panic disorder, phobic anxiety. (R, R2)
•Lower emotional resilience/more negative emotions/less able to handle negative events well.
•More impulsive (AA vs GG). (R) More significant in people who had AA for this gene AND TT for rs6313. (R)
•More depression – but relationship is complex. (R)
•Less Cooperative, Helpful and Empathic (AA, in females)(R)
•Less Extroverted (R)
•More neurotic (trended). (R)
•Higher Homocysteine – 10.4% in AA. (R)
•Higher risk of ADHD and ADHD severity (R)

Interesting.

I don't get any of those "bads". Maybe because it has such impact only on women.


More significant in people who had AA for this gene AND TT for rs6313. (R)

I have GG for that:

"rs6313","13","47469940","GG"


Drink decaf coffee.

Normal coffee doesn't make me "mania frenzy" though.

[War Chef]

What do you recommend for AAs? Or are we fine without taking anything?

Meditation.....

I think AA people have racing minds

but us GG, if we were any more chill, we'd be dead. :meditate:

[Nikephoros1]

Yeah yeah, whatever dumbass. Educate yourself before you have another bitch-fest.....

The COMT system is responsible for degradation of catecholamines (Dopamine, Norepinephrine etc.) It is written in neurology papers that people with two copies of AA have 300% more Dopamine than those with GG. GG people should in theory be addicted to coffee & need it to function, where if an AA person drinks coffee it brings about some sort of mania frenzy.

I suspect this is why Central Euro's (CEU) are such workaholics:

http://i.imgur.com/2ixhMZN.png

By the way, GG carriers respond well to something known as "modafinil" while AA don't respond at all (probably because they already have ample dopamine supply).

https://www.ncbi.nlm.nih.gov/pubmed/19037200?dopt=Abstract

This is very interesting. I might suggest trying Modafinil, or Piracetam if that sort of thing interests you. Also Noopept works quite well for me.

These drugs are considered Nootropics, I.e. they increase cognitive function, attention, memory, etc. They work by increasing certain neurotransmitters uptake like acetylcholine, whereas typical ADHD drugs like Adderall don't actually boost your "brain power", but rather just increase your dopamine and adrenaline levels which also helps with focus to an extent.

I much prefer the Nooptropic drugs though. No crash on the comedown, smaller addiction potential. I take Piracetam and Noopept regularly just to get me through the workday, and they've helped me significantly (I make a lot more money at work while taking them). I used to be almost unable to work like a normal person, my attention span was so awful and my motivation was nil. Work used to be hell for me.

This stuff has helped me function in a society that requires cogs and worker drones, which I certainly am not by nature. They're quite safe as well, so far as we know.

Btw, look up Piracetam and Noopept, they were both synthesized in Russia and Russian doctors prescribe them regularly for a number of ailments. The Russians are on to something, because I consider these far better drugs than the addicting, dangerous crap that American doctors prescribe.

[Peterski]

Are those drugs something similar to brain octane oil ???

[Nikephoros1]

Are those drugs something similar to brain octane oil ???

I'm not certain what that is, do you know the ingredients of it?

[War Chef]

^ All those "supplements" are worthless.

Only Modafinil is good from time-to-time because it has no side effects.... its not like Nazi-meth or anything even close.

Better to keep the mind empty.... only change thinking habits by erasing old ones & creating new ones (self-cognitive therapy). You don't need drugs for that.

[Nikephoros1]

Maybe its just placebo, or my mind is so fucked that I've had to cling to anything for help. It feels like I get so much out of it though, and they do have documented effects.

Meditation can help to a degree but the brain is not as simple as just "emptying" it. Ingrained neural pathways are extremely difficult to change, if they been formed over years and years of habit. A few weeks of mediation just can't change that, despite what some New Age-y gurus might claim.

[War Chef]

A few weeks of mediation just can't change that, despite what some New Age-y gurus might claim.

Meditation wasn't meant to change anything, but a tool to accept things the way they are. :old

[War Chef]

Ingrained neural pathways are extremely difficult to change, if they been formed over years and years of habit.

If they took years to form, they will take years to unwind. What's wrong with that? Years of conditioning from birth don't just change when you have a Eureka moment sitting on the toilet or whatever. You won't get instant results.

The best thing ever is to change thinking patterns. Every thought you ever have you should inquire "is this thought beneficial or will it just make me more degenerate?".

[Peterski]

Traditional Polish equivalent of meditation is going to church on Sunday. GGs would probably fall asleep out of boredom during a Catholic mass, while AAs even there feel excited, LOL.

[Nikephoros1]

Meditation wasn't meant to change anything, but a tool to accept things the way they are. :old

True enough, really there's little you can do to change these things. Not even your own body truly "belongs" to you, and the world can easily take it from you whenever it wills.

[Peterski]

How about some joga?

[Wrong]

My brain is swimming in Dopamine. AA.

You're right about that caffeine boost. I can only imagine what would happen with roids while blasting my favorite music.

[Not a Cop]

Somethings weird here. ... no AA or AG people on TA?

Maternal:

G. Mother A\G
G Father AA

Paternal both AA

Me- A\G

[Peterski]

Continental Differences:

G allele frequencies: East Asians have 71% G’s, Africans 69% G’s, Native Americans 61% G’s, Europeans 48% G’s (R). So East Asians are going to be more likely to have GG vs Europeans.

So AA is European as fuck.

[Wrong]

Continental Differences:

G allele frequencies: East Asians have 71% G’s, Africans 69% G’s, Native Americans 61% G’s, Europeans 48% G’s (R). So East Asians are going to be more likely to have GG vs Europeans.

So AA is European as fuck.

Makes sense. The AA's are the most explorative.

I have AA on Dopamine and GG on the MAOA Warrior gene.

[RN97]

AG

[Voskos]

i dont have this snp tested.

[firemonkey]

I have high dopamine. I don't cope with stress well. Thinking ability deteriorates under pressure.

AA-more linked with anxiety
GG- more linked with schizophrenia

[War Chef]

Doing another line of coke to make up for my weak COMT system, brb

[War Chef]

One of the most intriguing findings about this polymorphism is its apparent effects on the experience of pleasure. Not only does the met polymorphism seems to improve prefrontal cortex function, and possibly decreases psychosis risk, it actually makes people report better well-being.

Using a cool psychological technique called experience sample monitoring (ESM), Wichers et al. 2008 genotyped 492 subjects and gave them digital wristwatches and self-assessment forms. For 5 days, the watches would beep at a random time in ten blocks between 7:30 and 22:30. So for example, the watch might beep at 8:37, then 11:14, and so forth throughout the day, and at each beep the subject was told to record their “thoughts, current context (activity, persons present, and location), appraisals of current situation and mood.”

http://i.imgur.com/6tnrIBA.gif

“Reward experience on the continuum of event appraisal stratified by COMT genotype (event reference category is ‘neutral’).” Wichers (2007) Neuropsychopharmacology

Subjects with the met polymorphism reported more pleasure from what should have been equally pleasurable activities, and the effects were got bigger the more pleasurable an event was.

https://neuroamer.com/2012/06/29/card-sorting-pot-smoking-happiness-and-one-gene-comt-catechol-o-methyl-transferase/

On the plus side, we can think much more clearer than them. I know these types IRL.... they are often delusional & not very down-to-earth.

[Oneeye]

AG

[War Chef]

bumping another line of coke

[Kazimiera]

AA

[Peterski]

http://i.imgur.com/6tnrIBA.gif

^^^ So I am LL (met/met), right?

[Bosniensis]

A/G here.. so mixed bag lol xD

[Brás Garcia de Mascarenhas]

https://s26.postimg.org/7sqrrus89/image.jpg

[Kazimiera]

I enjoy life. I'm the eternal optimist. I find pleasure in the smallest things. I think in some way I have a childlike view of the world. Everything is exciting. I'm also a strange combination of cynical and naive. I know this doesn't really make sense but that is the way I am. Cynical in some cases, and naive in others. I have this belief that nobody is bad and nobody means harm to me, in the same way that I don't mean harm to anyone else. When someone is horrible to me I'm totally taken by surprise. But, being the eternal optimist, it doesn't really worry me.

On the downside, I deal with stress poorly. Extremely poorly. I tend to avoid situations which place me under stress but if I can't escape from it, it affects me physically. I don't have emotional meltdowns and start screaming or crying because I'm not very expressive in that sense, but if placed under a lot of pressure I get anxiety, I start shaking, heart palpitations, nausea. Fortunately I know by now which situations bring this on, and I successfully (most of the time) negotiate my way around them.

[Kelmendasi]

GG

[Maintenance]

A/G what does this mean?

[War Chef]

A/G what does this mean?

It means life is a struggle full of misery and mountains to climb. Every day teetering on the brink of extinction & fighting for survival. Any other questions?

[Maintenance]

It means life is a struggle full of misery and mountains to climb. Every day teetering on the brink of extinction & fighting for survival. Any other questions?

Sounds about right

[Hamlet]

GG

[Hamlet]

Doing a line of coke right now to make up for my weak COMT system.....

BuMP

Lol!

[SkyBurn]

AG

[War Chef]

I've come to the conclusion that the delirious mania of AA is not ideal, and neither is the apathetic sloth of GG.
AG is ideal:


https://www.youtube.com/watch?v=HPETcaQ3Z2o

[de Burgh II]

https://thumbs.gfycat.com/SpiffyTeemingGull-max-1mb.gif

https://s8.postimg.org/tujsa8b05/Untitled.jpg

[jingorex]

COMT rs4680 19951271 A or G A / A

[Dibran]

AG

What are the stats for AG? front page has description of AA and GG. What about AG?

[War Chef]

COMT rs4680 19951271 A or G A / A

Religion:
Caffeine and Hate.

[jingorex]

Religion:
Caffeine and Hate.


We all need balance, little brother.

[War Chef]

I am taking this seriously enough that I now supplement with a COMT inhibitor. Just minor differences like less laziness, more likely to fill up my gas when it's near empty, rather than holding it off for later, stuff like that : )

[Larali]

A/G


I am taking this seriously enough that I now supplement with a COMT inhibitor. Just minor differences like less laziness, more likely to fill up my gas when it's near empty, rather than holding it off for later, stuff like that : )

Sounds cool, where do you get that?

As far as dopamine goes, I do seek a rush from caffeine and other things... I am extremely type-A which is both a blessing and a curse... I am obsessive and worry constantly.

[War Chef]

Bump

[wisteria]

G/G

[MagnusDark]

A/G

Balance

[happycow]

A/G

[farke1]

A/G.

[War Chef]

A/G.

Vikings would probably been AA uber explorative adventurous types

[farke1]

Vikings would probably been AA uber explorative adventurous types
I would've thought they'd be the warrior types, perhaps the name is misleading me though.

[PaleoEuropean]

I would've thought they'd be the warrior types, perhaps the name is misleading me though.

They were jacks of all trades, warriors, politicians, explorers, capitalists and superior craftsmen.

[Jana]

G/G

I also have ''warrior'' gene. Could these 2 be connected ?

[visar]

A/A here

[Rædwald]

I'm A;G but I still have clinical depression or perhaps I'm just a cynical asshole. :coffee:

[War Chef]

G/G

I also have ''warrior'' gene. Could these 2 be connected ?

Do you mean MAOI Gene? It also stops degradation of Dopamine and Norepinephrine so they build up in brain, but via. a different pathway.

[Maintenance]

AG

[Vojnik]

Where on 23andme do you see this information?

[farke1]

Where on 23andme do you see this information?
Click on your username at the top right, and select "Browse Raw Data" from the drop-down menu. Then you can search the SNP (4680) in there and it will tell you which variants you have. :)

[Dorian]

GG

[Vojnik]

Variants: A or G
Genotype: A/G

[Sp_loa]

Me and My grandmother are both G,G

It's true for many things, but I actually thought I'd be A,G because I fit to some of the descriptions of A,A too.

[Prinses]

AA

[Longbowman]

AG. Perfectly balanced, as all things should be.

[War Chef]

BUMP for science

[War Chef]

http://i63.tinypic.com/24cvzte.jpg

You should try Modafinil

[Seya]

AG

[Dick]

You should try Modafinil

isn't that for treating narcolepsy?

[Daos777]

GG.

Lots of things make sense now lol.

[Impaler]

GG.

http://i.imgur.com/5BANVHZ.png (https://imgur.com/5BANVHZ)

[Adamm]

AA

https://i.imgur.com/9RkxkWm.png

[Celestia]

AG :)

[Coastal Elite]

Your Genotype = GG

https://i.imgur.com/Pls7UUe.jpg

[Coastal Elite]

GG.

http://i.imgur.com/5BANVHZ.png (https://imgur.com/5BANVHZ)

Clearly Dacian warrior traits

[Daos777]

Wait lower dopamine activity is associated with being a warrior? Are GG people more likely to be killers?


Sent from my iPhone using Tapatalk

[Daos777]

Also can anyone figure out if you can find this gene on 23 and me ?


https://www.google.com/amp/s/scientiasalon.wordpress.com/2014/07/31/the-extreme-warrior-gene-a-reality-check/amp/

[Dick]

Wait lower dopamine activity is associated with being a warrior? Are GG people more likely to be killers?


Sent from my iPhone using Tapatalk

Not necessarily more likely to be killers but more on the "edge";

Low Dopamine quiz:

3 Do you often feel down, flat, bored, or apathetic?

2 Tired, fatigued, low on physical or mental energy? Inability to feel pleasure?

2 Suffer from low drive, enthusiasm, and motivation?

2 Difficulty focusing or concentrating, ever been diagnosed with ADD?

3 Are you a thrill seeker or risk-taker?

3 Do you get easily chilled? Do you have cold hands or feet?

2 Tend to put on weight too easily?

3 Use a lot of coffee or other "uppers" like sugar, diet soda, ephedra, or cocaine to get motivated?

3 Have restless legs or tremors?



Total Score ___


Instructions: Add up the points for the questions you answered yes to.

If your score is more than 6 points then you are probably experiencing symptoms of low dopamine.

Stuff your mouth with 1000mg of PLP or Pyridoxal 5 Phosphate(an active coenzyme form of vitamin B6) and you'll feel like a different person, it can make your nerves go numb but then again that's the whole point, a zen-like feeling. I think it's best to be AG, in between.

[Adamm]

Is higher dopamine more associated with autism? Because I also score high on autism tests (I'm not diagnosed though).

[Dick]

Is higher dopamine more associated with autism? Because I also score high on autism tests (I'm not diagnosed though).

Honestly, yes it is hypothesized that it is associated with autism.

[Daos777]

Not necessarily more likely to be killers but more on the "edge";

Low Dopamine quiz:

3 Do you often feel down, flat, bored, or apathetic?

2 Tired, fatigued, low on physical or mental energy? Inability to feel pleasure?

2 Suffer from low drive, enthusiasm, and motivation?

2 Difficulty focusing or concentrating, ever been diagnosed with ADD?

3 Are you a thrill seeker or risk-taker?

3 Do you get easily chilled? Do you have cold hands or feet?

2 Tend to put on weight too easily?

3 Use a lot of coffee or other "uppers" like sugar, diet soda, ephedra, or cocaine to get motivated?

3 Have restless legs or tremors?



Total Score ___


Instructions: Add up the points for the questions you answered yes to.

If your score is more than 6 points then you are probably experiencing symptoms of low dopamine.

Stuff your mouth with 1000mg of PLP or Pyridoxal 5 Phosphate(an active coenzyme form of vitamin B6) and you'll feel like a different person, it can make your nerves go numb but then again that's the whole point, a zen-like feeling. I think it's best to be AG, in between.

I have every single thing listed. And thanks for the advice I’ll buy some of that tomorrow lol.

[Dick]

I have every single thing listed. And thanks for the advice I’ll buy some of that tomorrow lol.

Humans have evolved in a way that we don't get enough natural substances from our own production anymore, buy some calcium d glucarate as well, due to toxins in food and our unclean environment. Those "primitive" and backward neanderthals were probably more healthy and sane that most modern humans. We are evolving backwards and not forward. It's affecting people mentally, physically and obviously affecting our dna as well. Btw I am also GG so I've used myself as a "guinea pig" regarding intake of natural substances.

[Hulu]

Traditional Polish equivalent of meditation is going to church on Sunday. GGs would probably fall asleep out of boredom during a Catholic mass, while AAs even there feel excited, LOL.

:lol: word

[Coastal Elite]

People need to embrace their GG and not try to fight it. Be a warrior, wild and free.

[Luke35]

AG. Intermediate, as usual.

[Celestia]

AG. Intermediate, as usual.

That’s why we are so polite and kind :)

[Coastal Elite]

AG. Intermediate, as usual.

Not fair. It's too easy for you too be nice, I have to overcome my asshole genes to be nice.

[Zmey Gorynych]

AG.

[Slavic Italian]

That’s why we are so polite and kind :)

You mean it is why you are boring. Just kidding. AA.

[Moje ime]

Those "primitive" and backward neanderthals were probably more healthy and sane that most modern humans. We are evolving backwards and not forward. It's affecting people mentally, physically and obviously affecting our dna as well.

That correlates with what is written in Bible. Humanity fell in sin and suffer consequences on their mind and body.

[Celestia]

You mean it is why you are boring. Just kidding. AA.

Hahaha
That’s why we need an AA or GG to spice things up in our lives >:)

[War Chef]

Most successful/driven/fun people are AA. I'd imagine they feel like they are on adderall 24/7

Incels/basement nerds/gamers and unmotivated blobs are probably GG.

[Benyzero]

Most successful/driven/fun people are AA. I'd imagine they feel like they are on adderall 24/7

Incels/basement nerds/gamers and unmotivated blobs are probably GG.

On the other hand they are more vulnerable to stress and more prone to being unstable.. Iam AA... the price of the dopamine rush.

[War Chef]

On the other hand they are more vulnerable to stress and more prone to being unstable.. Iam AA... the price of the dopamine rush.

Life's a roller-coaster for ya'll.
For us it's a boring flat plain :)

[Benyzero]

Life's a roller-coaster for ya'll.
For us it's a boring flat plain :)

The coin has two sides :D

[Ylla]

GG

[Slavic Italian]

On the other hand they are more vulnerable to stress and more prone to being unstable.. Iam AA... the price of the dopamine rush.

Yep. AAs are eccentric and creative. They are most likely to be nerds.

[Slavic Italian]

Hahaha
That’s why we need an AA or GG to spice things up in our lives >:)

You are steady and insightful.

[Art23]

AA of course!

I agree that AA is probably more about extremes, while GG is moderate. It's not only excitement and pleasure for AA's, maybe it is just me, but I often feel depressed and don't handle stress well. Coffee or tea, no difference, I drink both.

P.S. Poles seem to have a lot of AA.
GG is high among Greeks&Balkan people.

[War Chef]

AA of course!

I agree that AA is probably more about extremes, while GG is moderate. It's not only excitement and pleasure for AA's, maybe it is just me, but I often feel depressed and don't handle stress well. Coffee or tea, no difference, I drink both.

P.S. Poles seem to have a lot of AA.
GG is high among Greeks&Balkan people.

It's probably higher in "northern" people. My speculation:
You need lots of dopamine (and noradrenaline) to survive winters.
In Mediterranean not so much, warm all year round.

[Art23]

It's probably higher in "northern" people. My speculation:
You need lots of dopamine (and noradrenaline) to survive winters.


Looking at your avatar... then why Native Americans and East Asians don't have it? Winters are harsher in continental areas of Asia than in Europe.

[War Chef]

Looking at your avatar... then why Native Americans and East Asians don't have it? Winters are harsher in continental areas of Asia than in Europe.

I don't know. Personality traits are sexually selected.

Passionate people are more attractive usually, they say

I guess for native Americans it doesn't apply. Also, I don't think we have data on Native Americans living in Canadian territories

[Dorian]

I don't know. Personality traits are sexually selected.

Passionate people are more attractive usually, they say

I guess for native Americans it doesn't apply. Also, I don't think we have data on Native Americans living in Canadian territories

Utah N/W ancestry residents/Finnish/British/Spain/Tuscan http://grch37.ensembl.org/Homo_sapiens/Variation/Population?db=core;r=22:19950771-19951771;v=rs4680;vdb=variation;vf=146106745
https://i.postimg.cc/9MH1BVVZ/afa.png (https://postimages.org/)

[War Chef]

Utah N/W ancestry residents/Finnish/British/Spain/Tuscan http://grch37.ensembl.org/Homo_sapiens/Variation/Population?db=core;r=22:19950771-19951771;v=rs4680;vdb=variation;vf=146106745
https://i.postimg.cc/9MH1BVVZ/afa.png (https://postimages.org/)

Crazy high in Finns. I think I'm onto something

[MagnusDark]

Me: AG

Father: AG