Genius and insanity DNA, 23andme, rs6994992, rs1800955, CRISPR, DRD4, NRG1

[Iloko]

Me:

rs6994992 (Genius & insanity) - C/C

rs1800955 (Increased novelty seeking) - C/T


https://www.youtube.com/watch?v=LtB_F67L1Lk

[Jana]

http://oi65.tinypic.com/2gxjvko.jpg

https://i.imgur.com/8AHYkg6.png

Both C/T - means what ?

[Iloko]

http://oi65.tinypic.com/2gxjvko.jpg

https://i.imgur.com/8AHYkg6.png

Both C/T - means what ?
https://investigativegenetics.biomedcentral.com/articles/10.1186/2041-2223-4-14
https://www.snpedia.com/index.php/Rs1800955

[firemonkey]

rs6994992 T/T
rs1800955 C/T

Not particularly creative . Am on depot antipsychotic.

[Caveat Emptor]

No way, wait, people have figured out what different genes from raw data file from 23andme are responsible for? How?

[Iloko]

No way, wait, people have figured out what different genes from raw data file from 23andme are responsible for? How?
https://investigativegenetics.biomedcentral.com/articles/10.1186/2041-2223-4-14
https://www.snpedia.com/index.php/Rs1800955

[Kaspias]

rs6994992 T/T
rs1800955 C/T

Not particularly creative . Am on depot antipsychotic.

rs6994992 T/T

rs1800955 C/T


I have anxiety disorder since 7 yo.

[firemonkey]

rs6994992 T/T

rs1800955 C/T


I have anxiety disorder since 7 yo.


I experience general and social anxiety.

[Dick]

How do you check this?

[Vessna]

rs6994992 C/T - intermediate creativity and psychotic tendencies

rs1800955 aka DRD4 infidelity gene - not phenotyped on 23andMe

[gixajo]

rs6994992 C / T

rs1800955 not genotyped

[Petalpusher]

https://i.postimg.cc/90YmCyvw/Capturegt3.png

https://i.postimg.cc/wTN5cMDy/Capturegt2.png

Evil genius + good boy :dev3

[HectorOfTroy]

https://i.ibb.co/58HJkfB/resulti.png

What does that mean? This is for the Genius-Insanity one. The 2nd one wasn't genotyped on my 23andme, I suspect I'm a strong novel seeker though.

[Vessna]

https://i.ibb.co/58HJkfB/resulti.png

What does that mean? This is for the Genius-Insanity one (?) I think. The 2nd one wasn't genotyped on my 23andme.

TT genotype is associated with increased creativity and psychotic traits

[HectorOfTroy]

https://i.postimg.cc/90YmCyvw/Capturegt3.png

https://i.postimg.cc/wTN5cMDy/Capturegt2.png

Evil genius + good boy :dev3

Clarify mine bro, also is there a reason my 2nd one isn't genotyped?

[HectorOfTroy]

TT genotype is associated with increased creativity and psychotic traits

Well that's funny because I'm the total opposite of that. I'm one of the most creative people I know, atleast in this country. And other people have said the same thing about me who see the stuff I do, so it's not just me saying it, and I've always been like that since as long as I can remember. There must be alot more genes for creativity than just this one, or this is just one of those things that years down the road scientists will say "nah guess we were wrong about this one" like they've done for many things already regarding psycho-biology in the past.

[kingmob]

i took a look into my nebula file,

rs6994992 TT
rs1800955 TT

first one is 'increased psycho/creative', right.

Can someone give me a tldr for the 2nd one?

Thank you in advance.

[Petalpusher]

Clarify mine bro, also is there a reason my 2nd one isn't genotyped?


In particular, the T/T genotype of the functional promoter polymorphism SNP8NRG243177 or rs6994992, which leads to increased neuregulin I gene expression, is associated with an increased risk of psychosis and other psychological and neurological phenotypes [3, 4]. Kéri investigated whether this particular DNA variant also has an advantageous effect. He studied 200 healthy volunteers with high intellectual performance as measured via a battery of tests and questionnaires, who were genotyped at the neuregulin 1 promoter DNA variant rs6994992. Grouping these 200 high intellectual achievers according to rs6994992 genotypes revealed that the T/T carriers had statistically significantly higher creativity measures compared with the C/C and the C/T carriers, with the C/T heterozygotes usually performing at an intermediate level relative to the T/T and the C/C homozygotes.

Is this evidence enough to support the conclusion that genius and madness are indeed related to each other because they are determined by the same gene? The author himself already admits some caveats in his study, such as that the findings were obtained from a selected group of people with high intellectual performance. It may be (as was not tested) that the observed effect is not found in an intellectually less-prominent sample.

As for the 2nd, either miscall or not covered by the chip you tested on (newer test less), bro.

[Dušan]

rs6994992 - CC

rs1800955 - missing in FTDNA raw data

[majevica]

rs6994992 T/T

[Grace O'Malley]

rs6994992 C/T

rs1800955 C/C

[Flashball]

Father:
rs6994992 (Genius & insanity) > C/C
rs1800955 (Increased novelty seeking) > not found in file

Mother:
rs6994992 (Genius & insanity) > C/T
rs1800955 (Increased novelty seeking) > not found in file


Myself (Nebula file):
rs6994992 (Genius & insanity) > C/C
rs1800955 (Increased novelty seeking) > C/C

Brother (Nebula file)
rs6994992 (Genius & insanity) > C/C
rs1800955 (Increased novelty seeking) > C/T

Sister (23anme file):
rs6994992 (Genius & insanity) > C/C
rs1800955 (Increased novelty seeking) > not found in file

[Cybele]

https://i.ibb.co/W34TRXs/922.png
https://i.ibb.co/ccqsFfx/955.png

[Brás Garcia de Mascarenhas]

https://i.imgur.com/zoHhZNK.png

https://i.imgur.com/tdOVcFx.png

[Luke35]

rs6994992 C/C - Well, I think C stands for creative.

rs1800955 - Not Genotyped.

[Benyzero]

i took a look into my nebula file,

rs6994992 TT
rs1800955 TT

first one is 'increased psycho/creative', right.

Can someone give me a tldr for the 2nd one?

Thank you in advance.

The 2nd one is a Drd4 (dopamine receptor type 4) snp which is a gene that can affect information processing and personality traits.. The CC one is associated with novelty seeking and impulsivity. And with more active receptor.

[kingmob]

The 2nd one is a Drd4 (dopamine receptor type 4) snp which is a gene that can affect information processing and personality traits.. The CC one is associated with novelty seeking and impulsivity.


Thanks, mate.

So, suffice it to say, my T;T falls within the 'normie' dopamine receptor range i take it.

[Benyzero]

Thanks, mate.

So, suffice it to say, my T;T falls within the 'normie' dopamine receptor range i take it.

ye its about 50/50 frequency in the population.

[Vessna]

DRD4 is a dopamine receptor gene, CC genetic variant associated with an increased likelihood of sexual promiscuity.

[Vessna]

Thanks, mate.

So, suffice it to say, my T;T falls within the 'normie' dopamine receptor range i take it.

you are less likely to gamble and cheat on your partner

[Demirkazık]

Father:
rs6994992 C/C

Mother:
rs6994992 T/T

Me:
rs6994992 C/T

[Beowulf]

rs6994992 - T/T

rs1800955 (not tested)

what does it mean?

[rothaer]

https://i.imgur.com/qS0Sfdn.jpg

[Melkiirs]

rs6994992 - T/T

rs1800955 (not tested)

what does it mean?

From SNPedia:


"[PMID 19594860] Associated with creativity (or at least people who answer ads asking for people who believe they have high creativity) in people with high intellectual and academic performance. Intriguingly, the highest creative achievements and creative-thinking scores were found in people who carried the (T;T) genotype, which was previously shown to be related to psychosis risk and altered prefrontal activation.

omim [PMID 17565985] rs6994992 in 5-prime promoter region of the NRG1 gene regulates expression of the NRG1 type IV isoform. The T allele, which is the schizophrenia risk allele, showed a 65% increase in promoter activity.

newscientist reports that this variation has been linked to psychosis, poor memory and sensitivity to criticism. About 50 per cent of healthy Europeans have one copy of this mutation, while 15 per cent possess two copies. "

https://www.snpedia.com/index.php/Rs6994992(T;T)

[Beowulf]

From SNPedia:



https://www.snpedia.com/index.php/Rs6994992(T;T)

Thank you for the information Milkaner!!

[Rædwald]

rs6994992 - C/C

rs1800955 - Not genotyped

[chinshen]

rs6994992 - C/T
rs1800955 - C/C

[Petalpusher]

In the world
Most C/C : Peru, Guinea (also the least T/T)
Most C/T : Korea, Kenya
Most T/T : Japan, China (also the least C/C)

For Europe, Tuscans are the most T/T. CEU (Colonial Americans) are the most C/T. Most C/C is UK.

https://i.postimg.cc/qrDL8KJN/Capturegt6.png

On average Europe is 36,4% (C/C), 50,3% (C/T) and 13,3% (T/T)

[Melkiirs]

In the world
Most C/C : Peru, Guinea (also the least T/T)
Most C/T : Korea, Kenya
Most T/T : Japan, China (also the least C/C)

For Europe, Tuscans are the most T/T. CEU (Colonial Americans) are the most C/T. Most C/C is UK.

https://i.postimg.cc/qrDL8KJN/Capturegt6.png

On average Europe is 36,4% (C/C), 50,3% (C/T) and 13,3% (T/T)

Could you link to the source? The allele frequency of T among the Ashkenazi aggregate on gnomAD is much higher than European Non-Finnish aggregate and comparable to South Asians (~0.49). Tuscans are genetically closer to Ashkenazim than most Europeans are so I'm curious if there is similarity in allele frequency.

[hazmatnik]

rs6994992 Build 37 31495581 C or T C / C
Build 38 31638065 C or T C / C

rs1800955 Build 37 636784 C or T not genotyped
Build 38 636784 C or T not genotyped

[Petalpusher]

Could you link to the source? The allele frequency of T among the Ashkenazi aggregate on gnomAD is much higher than European Non-Finnish aggregate and comparable to South Asians (~0.49). Tuscans are genetically closer to Ashkenazim than most Europeans so I'm curious if there is similarity in allele frequency.

It's on https://www.ensembl.org/

I closed the window and the site is slow as fuck so you ll have to do it again. There s no Ashkenazi ref there anyway. Finns have the second highest T off the top of my head after Tuscans.

[Melkiirs]

It's on https://www.ensembl.org/

I closed the window and the site is slow as fuck so you ll have to do it again. There s no Ashkenazi ref there anyway. Finns have the second highest T off the top of my head after Tuscans.


The data of the 1000 genomes project is much more limited than with gnomAD. The huge European Finnish and non-Finnish gnomAD 4.0 aggregates differ in T allele frequency by only 1.18 percent. Since the the UK Biobank is well over-represented in the European non-Finnish aggregate if the UK really has a lower frequency of the T allele than other Europeans the gap with the Finnish is even lower. I wonder how much variation in allele frequency actually exists in Europe.

As for Ashkenazi the Middle Eastern allele frequency from both gnomAD 4.0 and Human Genome Diversity Project although based on a relatively limited number of individuals indicate a notably higher frequency of the T allele than Europe. Combing the two sources for an allele number of 574 the T frequency is ~0.47. So accounting for genetic drift the outcome with Ashkenazi is not so surprising.

[Dantevici]

rs6994992 TT
rs1800955 not found

[Annihilus]

rs6994992 T/T