Post your best/worst Promethease genetic variants (or another health report)

[Matxe92]

https://i.imgur.com/Sb8LuFu.jpg
https://i.imgur.com/9Sy6Cuh.jpg
https://i.imgur.com/AFZqCKv.jpg
https://i.imgur.com/lwgZUoQ.jpg
https://i.imgur.com/q73Tvxf.jpg
https://i.imgur.com/mLbczTj.jpg
https://i.imgur.com/hopxulx.jpg



FIRE AWAY GUYS!

[farke1]

Forgot my login so I can't screenshot: but I have the same rs17070145(T;T) and rs2223841(G;G) genes that you have. Some other cool ones I can remember were rs12913832(G;G) associated with a 99% chance of having blue eyes, APOE-3 (3;3) which means I have no elevated risk of heart disease or mental degenerative disease, and I have a 50% stronger resistance to HIV. Time to book a flight to Thailand, boys. ;D

The negative ones I had were a 1.6x increased risk of coronary artery disease, a 3.5x increased risk of developing celiac disease, and stronger cravings for alcohol (although I don't remember the magnitude) - I don't really drink anyway so I'm not too worried about that one, though. I also had a gene that disposes me to a "22x higher chance of developing psoriasis in Asian populations", but since I have 0% Asian ancestry I'm just going to ignore that.

[Kaspias]

I hadn't slept well for one week when i see i scored bad - very bad for almost all cancer types. I don't want to check this page again, thanks

[Matxe92]

I hadn't slept well for one week when i see i scored bad - very bad for almost all cancer types. I don't want to check this page again, thanks

Hahaha, dude, remember that many any of the variants are still speculative, it's not like it's a perfect science 1 to 1 yet. Don't worry man ;)
Talking about the cancer ones here specifically.

I bet you can't beat my genetic defect, that makes me a carrier of a life disabling disease.

[Roy]

Hahaha, dude, remember that many any of the variants are still speculative, it's not like it's a perfect science 1 to 1 yet. Don't worry man ;)
Talking about the cancer ones here specifically.

I bet you can't beat my genetic defect, that makes me a carrier of a horrible rare disease.

You just need to order for your future procreative prospects to take genetic tests and choose one that does not have the same allele :coffee:

It also means that your progeny is quite likely to be ginger. :rolleyes:

[Matxe92]

You just need to order for your future procreative prospects to take genetic tests and choose one that does not have the same allele :coffee:

It also means that your progeny is quite likely to be ginger. :rolleyes:

Haha yeah...
Actually, on a serious note i am considering that heavily. Almost fully decided on it, but i think i'll swing by my doctor aswell to get his opinion on it.

I'll find a polish lady to create humans with lol in order to not have that ginger action happen :D

[Soraka]

My best variant with highest magnitude:

https://i.imgur.com/JzwQvL2.jpg

My worst variant with highest magnitude:

https://i.imgur.com/7bA43PJ.jpg

[dududud]

Good thread... bump!!!

[Rocinante]

Is there a way to check Haplogroup with MyHeritage raw data in Promethease?

[yowasgeht]

Well thats pretty bad ill guess. 11x times higher alzheimer(late onset) risk.



https://i.imgur.com/1EZAAuw.png

[nittionia]

fake news
https://i.imgur.com/DlTrv2w.png
https://i.imgur.com/tsjBgV8.png

[IrisSelene]

ok now i wanna buy this shit lol im buying it tomorrow right away lmao anyone knows how much it costs?

I only did genomelink for free and got 25 traits, i only learnt that im an alcoholic lol

[IrisSelene]

fake news
https://i.imgur.com/DlTrv2w.png
https://i.imgur.com/tsjBgV8.png

if i get the opposite we should sue them

[yowasgeht]

ok now i wanna buy this shit lol im buying it tomorrow right away lmao anyone knows how much it costs?

I only did genomelink for free and got 25 traits, i only learnt that im an alcoholic lol

Its free now

[PaleoEuropean]

Most my bad ones are generic white people crap like heart disease or are from non-white test populations so they don't really matter, these were the most serious and interesting ones I found skimming.
https://i.imgur.com/I4QsGxC.jpg
https://i.imgur.com/6HnvKdK.jpg
https://i.imgur.com/1FqxupF.jpg
https://i.imgur.com/Og0NtRh.jpg
https://i.imgur.com/Qm8FY80.jpg
https://i.imgur.com/SKyjOkr.jpg
https://i.imgur.com/OmFiHjL.jpg
https://i.imgur.com/wKLxSDH.jpg

Bad:
https://i.imgur.com/ZqynWAU.jpg
https://i.imgur.com/DZsIz0L.jpg
Bunch of heart disease ones with bad diet etc. just times the one posted by 10 xD.

[IrisSelene]

Its free now

omg you just made my day, thank you... i checked it some time ago and i remember it not being free lmao and it wasnt that long ago

[Daos777]

fake news
https://i.imgur.com/DlTrv2w.png
https://i.imgur.com/tsjBgV8.png

What’s your cup size

[Seya]

Type 2 Diabetes :/

[Cumansky]

Best: I guess ACTN3 muscle protein
Worst: I guess Mediterranean Fever

I don't have any predisposition that hectic from what I looked is all normal, but still focus to live healthy everyday

[Daos777]

Where is the Y Haplo I couldn’t find it anywhere?

[Celestia]

According to Promethease I should be pale (can’t tan) light hair and light eyes with small breast.
So all that is wrong.

But the medical conditions part seems possibly accurate.

[Coastal Elite]

https://i.imgur.com/QWUwVTM.jpg
https://i.imgur.com/LBhIfMJ.jpg

https://i.imgur.com/MMNRhKR.jpg
https://i.imgur.com/XJKf6O7.jpg

[malka]

https://i.postimg.cc/XJ6VjQFq/F1-BC89-DB-1-EC1-4-E50-8-F7-C-C1748108-E2-C6.jpg

That’s fun. /sarcasm

[Dick]

with small breast.
So all that is wrong.



http://www.sharegif.com/wp-content/uploads/2013/10/yes-gif-8.gif

[PaleoEuropean]

According to Promethease I should be pale (can’t tan) light hair and light eyes with small breast.
So all that is wrong.

But the medical conditions part seems possibly accurate.

Yea you can carry genes and not express them, there are always factors such as recombination etc, recessive traits etc. You also have to make sure the study was about your race because one thing that might cause cancer or effect someones appearance who is Asian, might not effect a Caucasian person.

[Celestia]

nick Jonas

I know how much you like them

https://www.theapricity.com/forum/attachment.php?attachmentid=91374&d=1568609727

[Celestia]

Yea you can carry genes and not express them, there are always factors such as recombination etc, recessive traits etc. You also have to make sure the study was about your race because one thing that might cause cancer or effect someones appearance who is Asian, might not effect a Caucasian person.

Lol yeah for a second I thought I inherited all the bad health genes until I realized it stated for specific races lol

[PaleoEuropean]

Lol yeah for a second I thought I inherited all the bad health genes until I realized it stated for specific races lol

Its pretty silly because even if you click a race they show all the studies for other races if you have the gene xD.

[Celestia]

Its pretty silly because even if you click a race they show all the studies for other races if you have the gene xD.

Seriously.
For a second I was about to plan my funeral with all the 1.2x risks I was getting

[Dick]

Lol yeah for a second I thought I inherited all the bad health genes until I realized it stated for specific races lol

maybe you were looking at the wrong thing for breast size

[Celestia]

maybe you were looking at the wrong thing for breast size

Nah it said I should have smaller breast than average
I should be taller than average
And obese

It didn’t get anything right as far as appearance goes.

[Dick]

https://i.imgur.com/7KLjx4F.jpg

[Celestia]

no soul

I already knew that one

[Dick]

I already knew that one

Don't care.

[Kazimiera]

https://i.imgur.com/q73Tvxf.jpg

I am also a carrier. :)

I also got markers for dementia. :(

Then I have plenty of markers for multiple sclerosis. Spot on - I have MS.

[rurov0]

Adding up all my hairloss genes, im 9x times more likely to go bald. And i also carry 3 more genes that make me have a higher chance of being bald. So simply put, i cannot wait!

[Seya]

Type 2 Diabetes :/

This is not the worse but the only one i got. Everything else is negative

[Thambi]

worst - prostate cancer
best - reduced risk for late onset (adult) asthma

[Benyzero]

I have mostly coronary artery disease risks,some cancer types, crohn disease. The best is probably Ill never have problems with cholesterol+ Im not really prone to autoimmune things

[Benyzero]

https://i.imgur.com/7KLjx4F.jpg

same brah :D

[Seya]

wow u people really got all those variants? i only got one and i was even feeling depressed because of that lol

[Benyzero]

wow u people really got all those variants? i only got one and i was even feeling depressed because of that lol

You are very lucky, if you really don't have any negative variants of those

[Seya]

You are very lucky, if you really don't have any negative variants of those

i guess i am. I do have one, as i said before. type 2 diabetes

[IrisSelene]

This is not the worse but the only one i got. Everything else is negativeYou're so lucky your family gave you healthy genes lol

I am positive for most of the cancers especially cervix, ovarian and breast. As well as all types of arthritis, Parkinson, type 1 and 2 diabetes, glaucoma, etc.

And on top of that, the highest magnitude I got is for being a carrier of tuberculosis and then to top it of, male baldness lol.

Enviado desde mi CLT-L09 mediante Tapatalk

[IrisSelene]

I'm also at high risk for bipolar disorder and schizophrenia but none of those things surprise. All these issues I know my family had them... So it's accurate.

Enviado desde mi CLT-L09 mediante Tapatalk

[Seya]

You're so lucky your family gave you healthy genes lol

I am positive for most of the cancers especially cervix, ovarian and breast. As well as all types of arthritis, Parkinson, type 1 and 2 diabetes, glaucoma, etc.

And on top of that, the highest magnitude I got is for being a carrier of tuberculosis and then to top it of, male baldness lol.

Enviado desde mi CLT-L09 mediante Tapatalk

Jesus..I hope u wont develop any of that. Do you know cases of such diseases in your family history?

[Benyzero]

https://i.imgur.com/i5zhUIa.png

[Benyzero]

https://i.imgur.com/cCntP7x.png lol

[Luke35]

I'm also at high risk for bipolar disorder and schizophrenia but none of those things surprise. All these issues I know my family had them... So it's accurate.

Enviado desde mi CLT-L09 mediante Tapatalk

I wouldn't worry about it Iris. When I was a kid I used to worry about a lot of, 'What if's?'. My mom taught me, never worry about things that aren't real problems yet.

So I say, forget about it, you'll never get most of that shit.

[Enr1989]

This is so cool I am gonna do it now

[RandomGuy20]

LOL not surprised at all with this one here -

https://i.imgur.com/To92eSk.png

Also my worst one.

My best:

https://i.imgur.com/BYJjIRi.png

[Lucas]

Best trait is 11 times less risk of baldness.
https://i.imgur.com/KLwiYYr.jpg

And I have three other alleles with decreased risk of baldness, but with weaker effect. And only one with some increasing risk.
And yes I'm not bald still:)

Best thing in Promethease is possibility to download all results to computer.

[Enr1989]

I have 1200 different variants

[WeirdLookingFellow]

My worst: at least 10 variants correlated to 7x risk of not reacting to antidepressants. Not that I would ever take them.

My gf: around 5 variants correlated to higher risk of prostate cancer. Good thing she doesn't have one.

[IrisSelene]

Jesus..I hope u wont develop any of that. Do you know cases of such diseases in your family history?I hope so too lol.

And yeah, all of those have been in my family. My mom's side, my grandpa died of tuberculosis and had many more diseases that I don't remember, oh and schizophrenia... And my grandma died of breast cancer and she had glaucoma.

My mom has arthritis and borderline disorder diagnosed.

On my dad's side, my grandma has diabetes, and lots of other issues lol.

My grandpa I'm pretty sure had cirrhosis cuz he had alcoholic issues.

And my dad had hypertension and heart issues.


And I know someone had Parkinson but I don't remember who lmao


Enviado desde mi CLT-L09 mediante Tapatalk

[IrisSelene]

I wouldn't worry about it Iris. When I was a kid I used to worry about a lot of, 'What if's?'. My mom taught me, never worry about things that aren't real problems yet.

So I say, forget about it, you'll never get most of that shit.Yeah I know. I also suspected most of it but it's still a shock to see it all confirmed. Especially tuberculosis. Lol

Enviado desde mi CLT-L09 mediante Tapatalk

[Seya]

I hope so too lol.

And yeah, all of those have been in my family. My mom's side, my grandpa died of tuberculosis and had many more diseases that I don't remember, oh and schizophrenia... And my grandma died of breast cancer and she had glaucoma.

My mom has arthritis and borderline disorder diagnosed.

On my dad's side, my grandma has diabetes, and lots of other issues lol.

My grandpa I'm pretty sure had cirrhosis cuz he had alcoholic issues.

And my dad had hypertension and heart issues.


And I know someone had Parkinson but I don't remember who lmao


Enviado desde mi CLT-L09 mediante Tapatalk

then it makes sense. it's interesting tho, that they detected all this. mine is also accurate. I do have elevated blood sugar. I always did. My fater also has it. But he didn't develope diabetes. my doc said it will probably never happen as i have a healthy lifestyle, I'm thin and active.
Your lifestyle is very important. it can prevent a lot of diseases. being carrier is not enough.

[Luke35]

Yeah I know. I also suspected most of it but it's still a shock to see it all confirmed. Especially tuberculosis. Lol

Enviado desde mi CLT-L09 mediante Tapatalk

I suggest you work out as much as you can; cardio and lift weights, keep yourself at a healthy weight. Eat a good variety of foods, the less processed the better. Use moderation with alcohol and don't smoke. You'll be fine.

[IrisSelene]

then it makes sense. it's interesting tho, that they detected all this. mine is also accurate. I do have elevated blood sugar. I always did. My fater also has it. But he didn't develope diabetes. my doc said it will probably never happen as i have a healthy lifestyle, I'm thin and active.
Your lifestyle is very important. it can prevent a lot of diseases. being carrier is not enough.Yeah, I was never overweight. I was never really thin, but always right where its most healthy for my height.

However, my eating habit is really bad, so that I should really work on lol

Enviado desde mi CLT-L09 mediante Tapatalk

[IrisSelene]

I suggest you work out as much as you can; cardio and lift weights, keep yourself at a healthy weight. Eat a good variety of foods, the less processed the better. Use moderation with alcohol and don't smoke. You'll be fine.Cardio is rlly hard for me to do... I really hate running and everything hurts when I do lol aside from getting super dizzy and being on the edge of fainting.

I am at a healthy weight but lately I've been having some issues, more than with weight itself, with retaining more body fat and liquids idk why.

I barely drink alcohol and I'm not into smoking anything.

Enviado desde mi CLT-L09 mediante Tapatalk

[dududud]

Magnitude set from 1.5 to 3.5
Frequency set to 0%.


Bad: 11

gs275
Increased risk (41.6% of white men) of Atrial Fibrilliation in one copy of both SNPs reported by 23andMe. One copy of each of the two atrial fibrillation 23andMe/SNPs is defective. This affects the formation of the heart and gives a high risk of Atrial Fibrillation (quivering of the top part of the heart). It also seems to increase the risk of Cardioembolic ischemic stroke (blocked blood flow to the brain) although 23andMe doesn't mention that. For European men, 23andMe reports this as a 41.6% risk, compared to the 27.2% average. The risk is lower for women. Based on several quality studies, and confirmed for Europeans and partly for Asians. It's recommended that you eat a heart-healthy diet, and only drink alcohol in moderation, to lower the risk. See a doctor for more information.

MTHFR polymorphisms affecting homocysteine You have a combination of 2 SNP variations in MTHFR which influence homocysteine levels. This is found in ~20% of people. 0.08% of people had a double copy of a mutation in one of the SNPs, and a single mutation in the other. [] . gs193 indicates double mutations in both snps, and people with this are believed to be critically impacted, however several promethease users have self reported this genotype with no apparent consequences.
• rs1801131 is at position 1298
• rs1801133 is at position 677
• http://www.mthfrheds.com/
• https://www.23andme.com/you/community/thread/5312/
• https://www.23andme.com/you/community/thread/2001/
• http://www.youtube.com/watch?v=ZA8GUIRqIkE MTHFR mutation frequencies in a sample of 37,000

rs53576(A;G)
Lack of empathy? You have a SNP in the oxytocin receptor which may make you less empathetic than other people. When under stress you may have more difficulty recognizing the emotional state of others which impacts loneliness, parenting, and socializing skills. Some studies have suggested that the A;G genotype is associated with an intermediate level of empathy (compared to the G;G and A;A genotypes), although most report that A;G and A;A individuals have similar levels of empathy and stress handling capabilities.

gs281
part of the 88% of the population claimed not to maintain weight loss unless you perform high energy exercise An interesting hypothesis, but not well validated, this patent is summarized in a simplified blog post and suggests a genotype to suggest diet and lifestyle changes which may be beneficial. Based on 2 snps
• rs4994
• rs1042713

rs7966230(C;G)
slightly lower levels of plasma VWF
rs7966230, also known as -1793G/C, is a SNP in the VWF gene on chromosome 12. This SNP is reasonably polymorphic in many populations. It does show a significant association with plasma VWF levels, reportedly more marked in subjects who are more than 40 years of age. The variant is reported to be associated with somewhat lower plasma levels of VWF. Publications discussing this mutation's discovery usually refer to the strand sequenced, since this is a SNP found upstream of the gene in the promoter region. The gene is transcribed in minus direction (based on the GRCh37 assembly), and so on the minus strand, the more common allele is (G) and the variant is (C). However, dbSNP defines this SNP on the plus strand (as does SNPedia and 23andMe), so the more common allele for rs7966230 is reported here as (C) and the variant as (G)....

gs249
Parkinson's Disease Risk 23andMe Patent Granted rs10513789(T) increased risk of developing Parkinson's Disease GenomicsLawReport points out that the earlier version covered more such as gs248 and gs247 See gs250 for the homozygote form

rs58920878(C;G)
slight (~1.5x) increase in colorectal cancer risk see discussion at rs58920878
rs58920878 on 18q21.1 ( colorectal cancer OR 1.49, CI: 1.14–1.95, P=0.0035)

rs1858830(C;C)
2x risk of autism reported by some (but not other) publications In some studies, but not others, the C allele appears to increase risk of autism by an odds ratio of about 1.8x; see discussion at rs1858830.
rs1858830, located in promoter of the MET gene, was originally reported in 2006 as being linked to a 2x increase in the risk of autism based on a study of ~700 families. From OMIM 164860: "In case-control analysis, the relative risk for autism was 2.27 for the CC genotype and 1.67 for the GC genotype compared to the GG genotype." However, since 2006, there have been several studies unable to replicate this association, as well as some replicating the finding, at least to varying degrees. These include:
• Those replicating to some degree the association with autism:
•
•: 2008 study with 100 families, from the same group that published the original 2006 association
•
•: 2009 study, reports odds ratio of 1.64 for C allele for autism association
• Those finding no association of rs1858830 to autism:...

rs33995883(A;G)
Slight (1.8x) increase in risk for Crohn's disease see discussion on main rs-page
rs33995883, also known as c.6241A>G, p.Asn2081Asp and N2081D, represents a variant in the LRKK2 gene on chromosome 12. The minor allele of this SNP was initially reported as potentially associated with Parkinson's disease; however, more recent reviews as well as the current annotation in ClinVar all conclude it is benign (at least with respect to Parkinson's). In 2018, a study of 2,000 patients with Crohn's disease found somewhat increased (~2x) risk for the disorder to be associated with rs33995883(G).

rs3843763(C;T)
Slightly lower HDL ('Good') Cholesterol. This slightly reduces levels of good HDL cholesterol in your blood. And that's usually bad, because HDL cholesterol actually cleans your arteries and transports cholesterol out of your body. Things that can help raise HDL cholesterol if it is too low include: quitting smoking, losing weight, exercise, and niacin (vitamin B3).
The (T) allele of rs3843763 was associated with risk for lower high-density lipoprotein (HDL) cholesterol plasma levels in 3 independent population samples, including both Caucasians and African-Americans.

rs1867277(A;G)
1.5x increased risk for thyroid cancer
rs1867277, also known as -283G>A, is a SNP upstream of the FOXE1 gene. Based on ~1,000 thyroid cancer patients (and an equal number of controls), a per allele odds ratio of 1.49 (CI: 1.30-1.70, p=5.9x10e-9) was found for the rs1867277(A) allele. This allele is thought to be a causal variant.





Good: 8

gs295
Lower heart attack risk than average You are in the 10 - 20 % of people (depending on the population studied) who carry three minor alleles at two SNPs, rs1108580 and rs1611115. This genoset is reported as having 0.46x the risk of a heart attack or cardiovascular incident compared to people who carry zero of the minor alleles for these two SNPs, based on a study of 3,000 African-Americans enrolled in the Jackson Heart Study.

gs310
Change in metabolism of certain substances Glutathione transferase (GSTz1) is the only enzyme known to biotransform DCA (an alternative cancer drug and a drug used in children with certain metabolic disorders). DCA is found in chlorinated water. GSTZ1 also serves as a bifunctional enzyme that catalyzes the penultimate step in tyrosine metabolism The effectiveness of the GSTz1 gene in enabling these reactions would change the level of DCA or tyrosine in someone's body. It has been found that a three haplotype SNP determines the speed of the GSTz1 enzyme. G94>A ( rs3177427) Glu → Lys at position 32; G124> A ( rs7972) Gly → Arg at position 42; and C245> T ( rs1046428) Thr → Met at position 82 in the GSTZ1/MAAI gene The rs1046428 snp is not the 23adnmev3 chip so rs10132619 which is a good proxy could be used in its place. (A promoter polymorophism, SNP-1002 G > A (...

rs3746444(T;T)
decreased cancer risk source
microRNA 1,009 breast cancer cases and 1,093 controls in a population of Chinese women
• rs3746444 in hsa-mir-499 A>G OR 1.25; 95% CI, 1.02-1.51 Genetic variants of miRNA sequences and non-small cell lung cancer survival. Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes. SNPs in human miRNA genes affect biogenesis and function. Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis. MicroRNA polymorphisms: a giant leap towards personalized medicine. Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population. Association of pre-microRNAs genetic variants with susceptibility in systemic lupus erythematosus. Association study of single nucleotide polymorphisms in pre-miRNA and rheumatoid arthritis in a Han Chinese population....

gs246
APOE E3/E3 Apo-ε3/ε3, the most common form of APOE. It is considered the "neutral" genotype, with E2 having lower risk and E4 having higher risk of Alzheimer's disease. Criteria: rs429358(T;T), rs7412(C;C)). Frequency
•European 57.4%
•African American 41.7%
•East Asian 74.6%Word of caution to those with data from Ancestry.com: in our experience, based on data in OpenSNP and from Promethease users since 2006, Ancestry data always reports rs429358 as (T;T), even for people who's data from other sources indicates they are (C;T). Therefore, until Ancestry corrects this false negative problem, be aware that the ApoE genosets assigned by Promethease will be inaccurate when based on (inaccurate) Ancestry data. Specifically, some percentage of Ancestry users who are supposedly gs246 positive (Apo-ε3/ε3) are actually either gs141 (Apo-ε3/ε4) or gs216 (Apo-ε4/ε4).

gs101
Probably able to digest milk 77% of Europeans with this are able to digest lactose and dairy products. People without this are more likely to experience lactose intolerance.

rs1129844(A;G)
Significant delay in onset of early-onset Alzheimer's; possibly a 2.5 year delay in onset of late-onset Alzheimer's One publication reports that the (A;G) genotype of rs1129844 might significantly delay the onset of early-onset Alzheimer's disease caused by a mutation in the PSEN1 gene. A followup study in late-onset Alzheimer patients found a 2.5 year later onset in those with AG versus GG genotype, but it was not statistically significant. This is an initial report and will need further replications. See additional discussion at rs1129844.
rs1129844, also known as c.208G>A, p.Ala23Thr and A23T, is a SNP in the CCL11 gene on chromosome 17. The CCL11 gene encodes eotaxin-1, a chemokine protein who's serum and cerebrospinal fluid levels increase with age and may correlate with decreased neurogenesis. This SNP has made the news based on a (single) study reporting that carriers of an rs1129844(A) allele might have delayed onset of Alzheimer's disease compared to individuals lacking an (A) allele. An analysis of 72 whole genome scans of selected Colombian PSEN1 E280A carriers, i.e. rs63750231(A;C) genotypes, all of whom have early-onset Alzheimer's, found that a protective haplotype delayed Alzheimer disease onset by up to 10 years. The only coding SNP in this protective haplotype associated with delayed AD onset was rs1129844...

rs35337543(C;G)
Somewhat reduced risk for developing hypothyroidism see text and links via main rs-page
rs35337543, also known as c.1641+1G>C, represents a variant in the IFIH1 gene on chromosome 2. Based on a study of UK BioBank participants, carriers of a rs35337543(C) allele are reported to be at reduced risk of developing hypothyroidism (OR 0.77, CI:0.70-0.85, p=5×10e−9).(

rs449647(T;T)
Normal levels of ApoE
Significant Alzheimer's disease associations with were found for rs449647(A;A) and rs405509(G;G) genotypes (positive), and rs449647(A;T) and rs405509(T;T)





Not set: 5

gs259
Homozygous for eye color haplotype #3 According to one publication this is blue eye color haplotype #3. However, feedback from Promethease users suggests it is not a reliable predictor of eye color.

gs256
carrier for a type of blue eyes Image:Gs256.jpg Heterozygous for what calls blue eye color haplotype #1. It seems 'blue', might be overstating it. In the eye color research community, there seems to be a distinction between the dark brown eyes typical for asian and african ancestry, and 'blue' for lighter eyes found in europeans.

gs285
claimed to lose 2.5x as much weight on a low fat diet An interesting hypothesis, but not well validated, this patent is summarized in a simplified blog post and suggests a genotype to suggest diet and lifestyle changes which may be beneficial. You are part of a group of 39% of all people. Source: http://rockstarresearch.com/these-5-genes-predict-what-kind-of-diet-and-exercise-is-best-for-your-body-2/ and http://www.faqs.org/patents/app/20100136561#b See also gs281, gs282, gs283, gs284 based on rs1799883 rs1801282 rs1042714 rs4994 and rs1042713

gs280
Light hair color for europeans You have one of the genotypes linked to light color hair. Appearance
• rs12821256(C;C)
• rs35264875(T;T)
• rs12896399(T;T)

gs232
Possible low pain sensitivity; LPS/LPS suggests you may be able to tolerate more pain than most people. However phased data may be necessary to increase certainty. See also gs232 gs233 gs234 gs235

[dududud]

Also good

rs7294919(C;C)
Enhanced hippocampal volume

rs7294919, showed a particularly strong link to a reduced hippocampus volume, suggesting that this gene is very important to hippocampus development or health. No associations for brain volume, but they did discover that intracranial volume was significantly associated with two loci: rs4273712, a known height locus on chromosome 6q22, and rs9915547, tagging the inversion on chromosome 17q21. The SNP is located between two genes, HRK [1] and FBXW8 [2], but evidence suggests that it influences the expression level of a gene 3’ to FBXW8, TESC [3]. Each copy of the T allele was associated with a 107.8 mm3 decrease in hippocampal volume [4]. In European populations, the effect allele (T) is found at frequency of 0.898 [5]. The minor allele (C) is found at a frequency of 0.102.

Background
The hippocampus is a critical brain structure involved in learning and memory. In particular, it is associated with the ability to form long-term memories of facts and events [6]. This is in contrast to short-term and working memory, which have been shown to be independent of the hippocampus [7]. Hippocampal size decreases with age and is diminished in several disorders including Alzheimer’s Disease [8], Major Depressive Disorder [9], Post-traumatic Stress Disorder [10], and Schizophrenia [11]. Moreover, the size of the structure is heritable, with estimates of heritability ranging from 40-70%

Studies
Two major studies were conducted which found an association between rs7294919 and hippocampal volume. They were published in the April 15th, 2012 issue of Nature Genetics [14][15]. Though the P-values and regression slopes differ, both studies, together comprising tens of thousands of individuals, agree that the T allele is negatively associated with hippocampal volume.

The first study uses the CHARGE consortium (Cohorts for Heart and Aging Research in Genomic Epidemiology) as its discovery cohort [16]. CHARGE comprises 8 sub-cohorts representing 9,232 people with an average age of 67.1 years. Most of the sub-cohorts were from Europe and hippocampal volume was determined using MRI. Second stage verification/replication was performed on two cohorts comprising 2,318 subjects. This study found that rs7294919 was associated with hippocampal volume with a meta-P value (combining the discovery and replication cohorts) of 2.9 x 10-11 and a regression slope (β) of -107.8 mm3 hippocampal volume.

The authors provide some speculation about the SNP’s mechanism of action by reviewing the neighboring two genes. HRK is involved in apoptosis of neurons and is thought to play a role in ischemia-induced apoptosis. FBXW8 targets an E3 ubiquitin ligase to protein aggregates and has been shown to be involved in hippocampal neuron dendrite growth. Potential pitfalls of this study include the older age of the participants, the mixture of both computerized and manual hippocampus tracing in MRIs, and the predominantly European ethnic makeup of the cohorts.

The second study’s discovery cohort comprised 17 European-ancestry cohorts representing 5,775 healthy people with a mean age of 34.8 years [17]. An additional 2,020 people with various neuropsychiatric disorders were also included to determine whether the SNPs had disease-specific effects. To verify/replicate their findings, they used several cohorts comprising both European ancestry and non-European populations (Yoruba and Los Angeles Mexican).

The study found that rs7294919 was associated with hippocampal volume with a combined P value of 1.99 x 10-7 with a regression slope of -42.74 mm3. The authors also examined the association of the SNP with IQ. While no association was found with full-scale IQ, a small association was found between having the C (minor) allele and an increase in verbal IQ (P = 0.043, β = 0.126). Using data from existing databases [18], rs7294919 (really rs4767492, a SNP used to impute rs7294919) was associated with expression of tescalin (TESC)[19], a gene which lies 3’ to FBXW8 in the brain. The T allele (associated with lower hippocampal volume) was associated with higher expression levels of TESC. TESC itself is expressed during brain development and is thought to regulate differentiation and proliferation. However, it is still not clear how increased TESC levels could be responsible for a decrease in hippocampal volume without additional studies.

[Benyzero]

How accurately this can predict blood type? For some reason I can't find my blood group in any documents, and for some reason I forgot it aswelll though the years. I have to be A or 0 . Every genetic reports tell that Im likely blood type 0, as well as this, should I trust it 100%?