Is this rare among Europeans?

[dududud]

My mother:
rs9264942(C;C)
90% reduction in HIV viral load The rs9264942(C;C) genotype is reported to be associated with a 90% reduction in viral load in HIV-infected individuals. [] See also rs9264942 and HIV.

[lei.talk]

The rs9264942mutation appears to help fight HIV infection by increasing the amount of HLA-C protein produced in the body. The protein helps alert the immune system to foreign particles, such as viruses, within cells. While HIV can disable similar proteins, known as HLA-A and HLA-B, it appears unable to do the same to HLA-C.

About 10% of Europeans appear to carry two copies of rs9264942, which leads to an average 90% viral load reduction. About 50% of Europeans carry one copy, which gives a 60% reduction. By comparison, less than 40% of people of African descent appear to carry a single copy of the polymorphism.

Fellay says that the new results from the study suggest that a vaccine to stimulate the action of HLA-C could help fight HIV.

Previous studies have found that certain genetic mutations, such the rare CCR5 mutation, can offer protection against the virus, but the new report is the first to show the impact of a variant affecting HLA-C.



Read more: https://www.newscientist.com (https://www.newscientist.com/article/dn12297-genetic-variation-may-lower-hiv-load-by-90/#ixzz64IT8baBm)

https://i.imgur.com/OaYNOmf.gif (https://www.google.com/search?q=rs9264942(C%3BC))

[dududud]

https://i.imgur.com/OaYNOmf.gif (https://www.google.com/search?q=rs9264942(C%3BC))

Thanks. Only 10%? Yeah i see. Where come from this gene? Indo-european?

[sailormoon]

Previous studies have found that certain genetic mutations, such the rare CCR5 mutation, can offer protection against the virus.



https://journals.plos.org/plosbiology/article/figure/image?size=inline&id=info:doi/10.1371/journal.pbio.0030339.g001


Lucotte and Mercier (1998) proposed a northern European origin and long-range dispersal consistent with the Viking-mediated dispersal of the CCR5 mutation. A north-to-south gradient correlating latitude with its frequencies was found, with highest allele frequencies in Denmark and Northern France, and the lowest allele frequencies in Corsica. It may be the Nordic Vikings who developed the rare mutation, which spread to the rest of Europe that they colonized since the 9th Century.

https://upload.wikimedia.org/wikipedia/commons/thumb/5/50/Viking_Expansion.svg/310px-Viking_Expansion.svg.png



Our large estimates of dispersal are consistent with the Viking hypothesis of Lucotte and Mercier [12]. Moreover, when selection is assumed to be spatially uniform, the maximum likelihood origin is in southern Finland. However, incorporating gradients in selection provided significantly better fits to the data, and in models with gradients, origins in Scandinavia did not have high likelihoods. Thus, our likelihood-based analysis provides some support for the Viking hypothesis in that we detect a strong signature of long-range dispersal events, but it also raises the possibility that the allele arose outside of Scandinavia and spread into the region via dispersers from the south.
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.0030339

[dududud]

Lucotte and Mercier (1998) proposed a northern European origin and long-range dispersal consistent with the Viking-mediated dispersal of the CCR5 mutation. A north-to-south gradient correlating latitude with its frequencies was found, with highest allele frequencies in Denmark and Northern France, and the lowest allele frequencies in Corsica. It may be the Nordic Vikings who developed the rare mutation, which spread to the rest of Europe that they colonized since the 9th Century.

https://journals.plos.org/plosbiology/article/figure/image?size=inline&id=info:doi/10.1371/journal.pbio.0030339.g001

Thanks. Do you think this is come from her father or her mother?

[Not a Cop]

Thanks. Do you think this is come from her father or her mother?

To have both copies it has to come from both sides.

[dududud]

To have both copies it has to come from both sides.

Thanks. Is this rare among sardinians (my mother is half sardinian)?

[PaleoEuropean]

Thanks. Only 10%? Yeah i see. Where come from this gene? Indo-european?

The origin is only speculative and most likely simultaneous.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663898/

[dududud]

The origin is only speculative and most likely simultaneous.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663898/

Thanks my redbeard.