dududud
12-18-2019, 06:58 AM
Available here:
https://www.ebi.ac.uk/ena/data/view/PRJEB35094
"Recent ancient DNA studies of western Eurasia have revealed a dynamic history of admixture,with evidence for major migrations during the Neolithic and Bronze Age. The population ofthe Mediterranean island of Sardinia has been notable in these studies in that Neolithic indi-viduals from mainland Europe cluster more closely with Sardinian individuals than with allother present-day Europeans. The current model to explain relative Sardinian differentiationis that the island received an initial influx of Neolithic ancestry and then remained relativelyisolated from expansions in the later Neolithic and Bronze Age that took place in continentalEurope. To test this model, we generated genome-wide capture data (approximately 1.2 millionvariants) for 70 ancient Sardinian individuals spanning the Middle Neolithic through the Me-dieval period, including individuals from Sardinia’s Nuragic culture, which is known for theconstruction of numerous large stone towers throughout the island. We analyze these new sam-ples in the context of previously generated genome-wide ancient DNA data from 961 ancientindividuals across western Eurasia and North Africa as well as whole-genome sequence datafrom approximately 1,500 modern individuals from Sardinia. The oldest ancient Sardinian in-dividuals in our study show a strong affinity to western Mediterranean Neolithic populationsand we infer a high degree of genetic continuity on the island to the Nuragic period (secondmillennium BCE). In particular, during the Bronze Age in Sardinia, we do not find significantlevels of the “Steppe” ancestry that was spreading in many other parts of Europe at that time.Only later, between the Nuragic period and the present, do we observe subsequent geneticinflux. We detect novel signals of admixture between 1,000 BCE and the present-day, from an-cestry sources in the eastern and northern Mediterranean, as well as North Africa in a subsetof post-Nuragic individuals. Within Sardinia, we confirm that populations from the more ge-ographically isolated mountainous provinces have experienced elevated levels of genetic driftand that northern and southwestern regions of the island received more gene flow from outsideSardinia. Overall, our genetic analysis sheds new light on the genetic history of Sardinia, re-vealing how relationships to mainland populations shifted over time. Together, these findingsoffer a refined demographic model for future medical genetic studies in Sardinia."
https://www.ebi.ac.uk/ena/data/view/PRJEB35094
"Recent ancient DNA studies of western Eurasia have revealed a dynamic history of admixture,with evidence for major migrations during the Neolithic and Bronze Age. The population ofthe Mediterranean island of Sardinia has been notable in these studies in that Neolithic indi-viduals from mainland Europe cluster more closely with Sardinian individuals than with allother present-day Europeans. The current model to explain relative Sardinian differentiationis that the island received an initial influx of Neolithic ancestry and then remained relativelyisolated from expansions in the later Neolithic and Bronze Age that took place in continentalEurope. To test this model, we generated genome-wide capture data (approximately 1.2 millionvariants) for 70 ancient Sardinian individuals spanning the Middle Neolithic through the Me-dieval period, including individuals from Sardinia’s Nuragic culture, which is known for theconstruction of numerous large stone towers throughout the island. We analyze these new sam-ples in the context of previously generated genome-wide ancient DNA data from 961 ancientindividuals across western Eurasia and North Africa as well as whole-genome sequence datafrom approximately 1,500 modern individuals from Sardinia. The oldest ancient Sardinian in-dividuals in our study show a strong affinity to western Mediterranean Neolithic populationsand we infer a high degree of genetic continuity on the island to the Nuragic period (secondmillennium BCE). In particular, during the Bronze Age in Sardinia, we do not find significantlevels of the “Steppe” ancestry that was spreading in many other parts of Europe at that time.Only later, between the Nuragic period and the present, do we observe subsequent geneticinflux. We detect novel signals of admixture between 1,000 BCE and the present-day, from an-cestry sources in the eastern and northern Mediterranean, as well as North Africa in a subsetof post-Nuragic individuals. Within Sardinia, we confirm that populations from the more ge-ographically isolated mountainous provinces have experienced elevated levels of genetic driftand that northern and southwestern regions of the island received more gene flow from outsideSardinia. Overall, our genetic analysis sheds new light on the genetic history of Sardinia, re-vealing how relationships to mainland populations shifted over time. Together, these findingsoffer a refined demographic model for future medical genetic studies in Sardinia."