Genes that may raise the risk of dying from Covid-19 were inherited from NEANDERTHALS that lived up

[Hulu]

Genes that may raise the risk of dying from Covid-19 were inherited from NEANDERTHALS that lived up to 60,000 years ago, study claims

Genetic code was first spotted in a Neanderthal from Croatia 50,000 years ago
It is still prevalent in people in South Asia and particularly Bangladesh
The genes are also found in around 8% of Europeans and 4% of Americans
May have affected immune system in history and now raise risk of over-reaction

https://www.dailymail.co.uk/news/article-8493669/Genes-raise-risk-dying-Covid-19-inherited-NEANDERTHALS.html

[Crimea-Khan]

100501

[Crimea-Khan]

Genetic code was first spotted in a Neanderthal from Croatia 50,000 years ago

[Zoro]

The scientific paper lists the following risk SNPs. The only problem is I don't think any of the commercial DNA companies genotypes them.

3 45871908
3 45867440
3 45864732
3 45862952
3 45861932
3 45859651
3 45880481
3 45889921
3 45889949
3 45899651
3 45801089
3 45888690
3 45808116
3 45809024
3 45876460
3 45876459

[Petalpusher]

https://i.imgur.com/cEIZuVs.png

[Hulu]

100501

wow 165, that's the lowest neanderthal I've seen. Mine is 273 and on the 44 percentile.

[Lemminkäinen]

Out of the 2,872 variants we tested, we found 272 variants in your DNA that trace back to the Neanderthals.

All together, your Neanderthal ancestry accounts for less than ~2 percent of your DNA.

[Zoro]

100501

I have a hard time believing that a Russian or Tatar would only get 165 variants or 4% of 23andme customers. I would think that level would be for North Africans or maybe even east Africans?

Because on the V5 chip even kurds get more than 67% of 23andme customers out of 7400 Neanderthal variance tested so I would think that Russians should get even more than that

On V4 chip 23andme was only testing 2800 Neanderthal variants but even then Kurds were getting 270 variants

[Lemminkäinen]

The scientific paper lists the following risk SNPs. The only problem is I don't think any of the commercial DNA companies genotypes them.

3 45871908
3 45867440
3 45864732
3 45862952
3 45861932
3 45859651
3 45880481
3 45889921
3 45889949
3 45899651
3 45801089
3 45888690
3 45808116
3 45809024
3 45876460
3 45876459

I had only 45864732 and it was not a risk allele, mine is homozygous TT. I can impute more, giving a statistic idea.

[Lemminkäinen]

I have a hard time believing that a Russian or Tatar would only get 165 variants or 4% of 23andme customers. I would think that level would be for North Africans or maybe even east Africans?

Because on the V5 chip even kurds get more than 67% of 23andme customers out of 7400 Neanderthal variance tested so I would think that Russians should get even more than that

On V4 chip 23andme was only testing 2800 Neanderthal variants but even then Kurds were getting 270 variants

In general Russians have a medium/high level of Neandethal ancestry, but it doesn't necessarily correspond with the Covid-19 risk.

[Ülev]

yeah, those who were tested can be easily turned off :) (by c19)

[Zoro]

In general Russians have a medium/high level of Neandethal ancestry, but it doesn't necessarily correspond with the Covid-19 risk.

I know that’s why i said it’s hard for me to believe that a russian would only get 165 variants or 4% of 23andme customers. You’re right the covid19 associated risk ones on chr 3 i listed the paper says peek in Indians That’s why I was quick to check mine and some of my relatives data because for some odd reason we kurds often carry the same allelles as S Asians but it seems like none of the companies test for those snps so i can’t see them

This paper and other papers also found an association between COVID-19 and Alleles on chromosome 9. Those alleles are associated with blood group but the risk increase due to those is not as high as the ones on chromosome 3 according to the paper. So blood O+ seems to lower risk and A and B have higher risk. I’m B+ which is kind of rare everywhere except as luck would have it in China and India where it’s common. That’s why whenever i see Indians and Chinese have a higher than normal risk allele i check my family since it seems my family has inherited the bad stuff from Indians and chinese lol

Another bad one my family got from china is a SNP that raises stroke chances. That SNP worldide is 0-1% but china has 40%

[Hulu]

I had only 45864732 and it was not a risk allele, mine is homozygous TT. I can impute more, giving a statistic idea.

What did you check?

[Lemminkäinen]

What did you check?

Obviously from older FamilytreeDna's data. I have combined all sources I have, so I can't say it just now. Also, you see that there is a strong LD between this haplotype and probably with several SNPs. So studying LD impacts would be fruitful. Very likely I have not this risk haplotype.

I have also my imputed data based on 23andme data, made by Reich Lab in an older project, and also this shows ancestral Homo Sapiens alleles.

We have also a strong Finnish data in 1000genomes, obviously including this Neanderthal haplotype. This is the first time I regret that I didn't partake in this project, but I was cautious of the possibility to come revealed in other projects and didn't join.

[Crimea-Khan]

I have a hard time believing that a Russian or Tatar would only get 165 variants or 4% of 23andme customers. I would think that level would be for North Africans or maybe even east Africans?

Because on the V5 chip even kurds get more than 67% of 23andme customers out of 7400 Neanderthal variance tested so I would think that Russians should get even more than that

On V4 chip 23andme was only testing 2800 Neanderthal variants but even then Kurds were getting 270 variants

We are Scythian, but I am outlier I get 25% Natufian in ancient runs