Incorrect Y-DNA Results

[VikLevaPatel]

Two Against One. Y-DNA results do not match (Haplogroup E1b1b vs. C-K466). :confused::picard2::picard1::picard2::picard1:

The first test over 5 years ago from ISO 17025 AND NATA ACCREDITED DNA Solutions (https://dnasolutions.com.au/) (Australian Accredited DNA Testing Laboratory and Winner of contract with Aust. defence force) showed me to be of Y Haplogroup E1b1b and mtDNA haplogroup W6.

110663
110664

The mtDNA haplogroup W6 is correct as FTDNA is also showing the same mtDNA result.

But my FTDNA "Confirmed Y-DNA Haplogroup" is C-K466.

Now, my Y-DNA test results from AABB-accredited DDC (DNA Diagnostics Center) in Cincinnati Ohio (https://dnacenter.com/) are showing me to be of Y Haplogroup E1b1b. This Paternal Lineage Report states:


Haplogroup E1b1b
Time Of Origin: 24-27,000 years ago
Place of Origin: West Africa
Description
E1b1b is the third most common haplogroup in Europe. It is
also common among North African populations and
Southwest Asia. It is also a founding lineage of Ashkenazi
Jews.

The report goes on to say, "Famous people who belonged to Haplogroup E include William Harvey, a famous English physician who was the frst in the Western world to describe systemic circulation (the process by which blood is carried away from the heart into the body, and back into the heart). Also, the Wright Brothers (Wilbur and Orville), who are credited with building the world’s frst successful airplanes, belong to this haplogroup. They all belong to the specifc branch, E1b1b1."

[Pine]

You're C-K466.

[VikLevaPatel]

So basically the FTDNA 'Big Y' tests are *not* done accurately. IN MY CASE ANYWAY.


So what does the accuracy of my ancestry test depend on?
The accuracy of your DNA heritage test mostly depends on the database used by the laboratory and how comprehensive this database is.
https://archive.md/0OrMg#selection-977.0-983.94

:ranger


Assuming the tests are done accurately, some discrepancies can still arise from differences in the companies’ DNA databases. Almost every DTC genetic test does not sequence your entire genome, but instead looks at positions in your DNA that are known to be of interest. When I was tested by 23andMe, they proclaimed I do not carry a version of a gene that is associated strongly with red hair. Another ancestry company said I did. This merely reflects the fact one company was looking at different variants of the gene that code for ginger hair.

If we assume the data generated is accurate, then the second question that arises is on the interpretation. And this is where it gets murky. Many of the positions of interest in your DNA are determined by experiments known as Genome Wide Association Studies, or GWAS (pronounced gee-woz).
https://archive.md/3ZttA#selection-661.0-661.125

Why do the tests return different results? (https://archive.md/ovazn#selection-629.0-649.400)

Each company offering these services uses its own proprietary database of DNA samples called ancestry informative markers (AIMs) from current populations in Asia, Africa, Europe, and the Americas. From within those databases, they each select for a certain number of alleles—one member of a pair of genes located at a specific position on a specific chromosome—and in these spots, use the genetic variations known as single nucleotide polymorphisms (SNPs) as the basis for evaluating individuals. The markers—SNPs—are chosen because they have different frequencies across different geographical populations.

They compare SNPs with those most frequently associated with different populations in their reference database. The results are in no way definitive; instead each company uses common genetic variations as the basis for saying the probability is that 50 percent of your DNA is, for example, from North Europe and 30 percent is from Asia, based on how it compares to the information in its database. However, if you send DNA to a second company, you might get different results, because it has a different database. Studies that have compared ancestry databases have found poorer concordance with Hispanic, East Asian, and South Asian descent.

What else might make your ancestry results inaccurate? (https://archive.md/ovazn#selection-655.0-667.285)

There’s a big chunk of data—actually the majority—that these genetics-testing services don’t use. Your DNA contains millions of SNPs, but these tests are selectively looking at certain genetic variations and use between 100 to 300 AIMs, which account for a small part of the SNPs that differentiate the human family. So even if a test says you are 50 percent European, really it can only report that half of those SNPs of your DNA looks to be European.

The results are further skewed by the fact that certain ancestry information markers used by any particular test may come from only your paternal line (Y chromosome) or your maternal line (mitochondrial DNA). Tests using these markers are less accurate.

Finally, these testing services use DNA from modern populations in these regions to draw conclusions about people who lived in those areas hundreds or thousands of years ago. It’s a big leap to assume that the particular SNPs used by the tests have remained constant for all that time.

[zebruh]

I would trust ftdna more. Try a 3rd ydna testing company thats reputable for Haplogroup testing


https://nebula.org/whole-genome-sequencing-dna-test/?%7Blpurl%7D%3FGA_network=g&gclid=Cj0KCQjw8p2MBhCiARIsADDUFVHZM9ARoOr68Y_TUt_P McwEaL04UWMWCFa8IX4bDIcte10Mst4psa8aAuj_EALw_wcB


Is probably a good one because it covers alot I think

Then take your. Bame file and upload to yfull and see where it places you.

[zebruh]

Oh yes and 23andme always had shitty ydna testing. They till this day, still use a y tree from 2012 I think.

[Pine]

So basically the FTDNA 'Big Y' tests are *not* done accurately. IN MY CASE ANYWAY.


https://archive.md/0OrMg#selection-977.0-983.94

:ranger


https://archive.md/3ZttA#selection-661.0-661.125

Why do the tests return different results? (https://archive.md/ovazn#selection-629.0-649.400)


What else might make your ancestry results inaccurate? (https://archive.md/ovazn#selection-655.0-667.285)

Are you retarded? You're C-K466.

[Leto]

So basically the FTDNA 'Big Y' tests are *not* done accurately. IN MY CASE ANYWAY.


https://archive.md/0OrMg#selection-977.0-983.94

:ranger


https://archive.md/3ZttA#selection-661.0-661.125

Why do the tests return different results? (https://archive.md/ovazn#selection-629.0-649.400)


What else might make your ancestry results inaccurate? (https://archive.md/ovazn#selection-655.0-667.285)
Since you're on this forum, please share your Gedmatch results, we'll add you to the members' database :)

[CommonSense]

FTDNA is a top class company when it comes to Y-DNA testing. The other two are so obscure that even those who are the most devoted to genetics research haven't heard of them.

[Adamm]

WGS + YFULL = accurate y-dna

[VikLevaPatel]

The hit and miss of FTDNA and 23andMe :confused: :picard1: Is this some kind of joke :confused::picard2::confused:


So, let's see if this new service is any improvement to my results, compared with the hit and miss of 23andMe, and Family Tree DNA (FT-DNA). Will they be able to identify and locate my English roots successfully? What will the improved chip make of my haplogroups?
https://archive.md/IqLeb#selection-1631.0-1631.266


The Chip

They will be using a custom version of the latest Illumina chip technology, the Global Screen Array (GSA). It is encoded with:

650,000 autosomal DNA SNPs
20,000 Y-DNA SNPs
4,000 MT-DNA SNPs.

In comparison for example, the 23andMe V4 chip scans for:

577,000 atDNA SNPs
2,329 Y-DNA SNPs
3,100 MT-DNA SNPs.

I hope that LivingDNA will also use up-to-date haplogroup nomenclature and information. 23andMe with their V4 chip still use very dated 2009 nomenclature.

https://archive.md/IqLeb#selection-1145.0-1630.0

Wow, there may still be some hope after all in DNA testing.

Sending out my LivingDNA kit to Denmark today.

I also certainly hope and expect that the LivingDNA and 23andMe paternal results match. In the same or similar way as this person's matching DNA results:


Maternal and Paternal Migrations

Analysis of my mitochondrial DNA (mtDNA) associates me with maternal haplogroup H (subclade H2a) which identifies ancestors who migrated around Europe, the Middle East, and Africa as shown here:

This agrees with analysis by 23andMe, so I conclude that both companies are probably correct.

Analysis of my Y-DNA associates me with paternal haplogroup J2 (subclade J-M92) which identifies ancestors who migrated around Iberia, the Middle East, and Africa like this:

Again, this analysis agrees with 23andMe.

https://archive.md/zDzaW#selection-2435.0-2435.32

[Peterski]

Try YSEQ.

[E1b1b]

WGS + YFULL = accurate y-dna

This is the best way to do it. I recommend anyone interested in dna testing to just save up for nebula genomics or some other wgs test. Don’t waste your money on 23 and me

[Pine]

Try YSEQ.

He's C-K466. There is no doubt about it.

[Peterski]

He's C-K466. There is no doubt about it.

I agree but YSEQ will confirm his FTDNA result.

[ANXIETY (ADEPT)]

That's peculiar. You probably just have more complicated DNA. I've heard of some cases where 23andme gets it wrong, but my 23andme and FTDNA (at least the Y haplos) seem to match

[GalenStark]

Of 23andme and FTDNA have you at C-K466, you're C-K466.