Blond Hair SNPS [Archive] - The Apricity Forum: A European Cultural Community

Grace O'Malley

12-01-2021, 04:52 AM

This SNP influences appearance and is located in the TPCN2 gene. A study [PMID 18488028] of 5130 Icelanders (with further followup in another 2116 Icelanders and 1214 Dutch individuals) found significant association between a group of SNPs within the TPCN2 gene. All of the discovered difference between blonde and brown hair could be explained by genotypes with rs3829241 and Rs35264875. The A allele was significantly associated with blonde versus brown hair with a P-value 6.2e-16

https://postimg.cc/tsx04sBY

Just wondering what people have on this? These are mine below. I have light brown hair with a reddish tint.

These are my results.

https://i.imgur.com/YS78xUL.png

https://i.imgur.com/FCgMZ6T.png

Ellethwyn

12-01-2021, 05:02 AM

I have not done any DNA test, but I had my dad do 23andme. He had light blonde hair, as do I. Here is his...

https://i.imgur.com/aNECr9Q.png

https://i.imgur.com/1WHuioa.png

Grace O'Malley

12-01-2021, 05:06 AM

I have not done any DNA test, but I had my dad do 23andme. He had light blonde hair, as do I. Here is his...

https://i.imgur.com/aNECr9Q.png

https://i.imgur.com/1WHuioa.png

It is interesting how it works. A is the recessive gene. Thanks for replying.

Mortimer

12-01-2021, 05:13 AM

Svetozar, the combination of your genetics and other factors make you more likely to have darker hair.
Of 23andMe research participants with results like yours:
< 1% have light blond hair.

2% have dark blond hair.

15% have light brown hair.

67% have dark brown hair.

16% have black hair.

About your Light or Dark Hair result
Your result for this trait was calculated using a statistical model.

About the Light or Dark Hair model
Created based on customers of ethnicity: European
Number of customers used to create: 60,000
Number of markers: 42
Area Under Curve (AUC): 0.7
Non-genetic factors: Age, Sex
Bin # Black Dark brown Light brown Dark blond Light blond
1 0.26% 12.54% 25.43% 45.27% 16.50%
2 0.43% 16.37% 31.72% 39.67% 11.82%
3 0.72% 20.79% 33.29% 35.32% 9.89%
4 0.49% 24.32% 34.89% 33.09% 7.20%
5 0.82% 27.59% 35.38% 29.33% 6.87%
6 0.95% 31.16% 35.84% 26.81% 5.24%
7 1.18% 32.44% 37.15% 24.32% 4.91%
8 0.92% 34.70% 38.23% 21.96% 4.19%
9 1.21% 37.48% 36.50% 20.69% 4.12%
10 1.44% 39.84% 36.17% 18.85% 3.70%
11 1.51% 42.82% 35.22% 17.09% 3.37%
12 2.13% 43.96% 35.32% 16.10% 2.49%
13 2.82% 47.23% 34.08% 13.45% 2.42%
14 2.98% 50.70% 30.64% 13.06% 2.62%
15 3.57% 52.37% 32.08% 9.79% 2.19%
16 3.96% 55.24% 29.54% 9.63% 1.64%
17 5.57% 57.20% 27.77% 7.76% 1.70%
18 6.97% 61.03% 24.72% 6.22% 1.05%
19 8.68% 64.83% 20.89% 4.78% 0.82%
SP20 15.88% 66.99% 14.47% 2.23% 0.43%
Overall European 3.12% 40.98% 31.47% 19.77% 4.66%

TPCN2 rs3829241 68855363 A or G G / G

TPCN2 rs35264875 68846399 A or T A / A

Mopi The Dire Wolf

12-01-2021, 05:26 AM

for rs3829241 my genotype is AG
for Rs35264875 my genotype is AA

calxpal

12-01-2021, 05:38 AM

rs3829241 G/G

Rs35264875 A/T

Defcon2

12-01-2021, 05:50 AM

rs3829241 nor genotyped :(

rs35264875 A/T

4% have light blond hair.

22% have dark blond hair.

38% have light brown hair.

35% have dark brown hair.

1% have black hair.

hmaohma78

12-01-2021, 06:02 AM

rs3829241
Not genotyped
rs35264875
A/A
I have dark brown hair
As for blond hair; I only have small strokes of blond hair.

Mixdguy17

12-01-2021, 06:22 AM

I got this, idk really know what it mean, but I have medium-light brown hair.

https://i.imgur.com/v9qZVN8.png
https://i.imgur.com/Wljxc8m.png

Grace O'Malley

12-01-2021, 06:24 AM

I got this, idk really know what it mean, but I have medium-light brown hair.

https://i.imgur.com/v9qZVN8.png
https://i.imgur.com/Wljxc8m.png

I wonder if you are on v5 of 23&Me? They use a lot less snps on the later versions.

Mixdguy17

12-01-2021, 06:35 AM

I wonder if you are on v5 of 23&Me? They use a lot less snps on the later versions.

Yep, v5.9 apparently. What do the results say really?

Grace O'Malley

12-01-2021, 06:47 AM

Yep, v5.9 apparently. What do the results say really?

Well A is the blond haired snp and you carry one on that. The older versions of 23&Me was better in my view because they tested a lot more snps.

Mixdguy17

12-01-2021, 06:51 AM

Well A is the blond haired snp and you carry one on that. The older versions of 23&Me was better in my view because they tested a lot more snps.

kool, thx Grace!.

Defcon2

12-01-2021, 11:50 AM

It is interesting how it works. A is the recessive gene. Thanks for replying.

The recessive blonde hair gene for rs35264875 is not T? although sometimes it seems confusing to me.

Geno Mag Summary
(A;A) 0 common in clinvar
(T;T) 3 blonde hair color

https://www.snpedia.com/index.php/Rs35264875

Grace O'Malley

12-01-2021, 12:05 PM

The recessive blonde hair gene for rs35264875 is not T? although sometimes it seems confusing to me.

Geno Mag Summary
(A;A) 0 common in clinvar
(T;T) 3 blonde hair color

https://www.snpedia.com/index.php/Rs35264875

Now I'm confused??

https://i.imgur.com/YSlfENH.png

Is one A and one T? How confusing! :confused:

Defcon2

12-01-2021, 12:11 PM

Now I'm confused??

[img]https://i.imgur.com/YSlfENH.png

Is one A and one T? How confusing! :confused:

Correct in the case of rs3829241 the A allele is associated with blonde hair, in the case of rs35264875 it is the T allele. :)

The A allele was significantly associated with blonde versus brown hair with a P-value 6.2e-16

https://www.snpedia.com/index.php/Rs3829241

Grace O'Malley

12-01-2021, 12:13 PM

Correct in the case of rs3829241 the A allele is associated with blonde hair, in the case of rs35264875 it is the T allele. :)

The A allele was significantly associated with blonde versus brown hair with a P-value 6.2e-16

https://www.snpedia.com/index.php/Rs3829241

Thank you for pointing that out. Now people can recheck. :)

Gallop

12-01-2021, 12:55 PM

I have checked them for both in Sequencing.

Father

Chr 11 Position 68855363 rs3829241 G/A
Chr 11 Position 68846399 rs35264875 A/T

Mine

rs3829241 G/G
rs35264875 (No results found)

Gallop

12-01-2021, 01:10 PM

My father has also obtained these results, I don't know exactly which marker he must be referring to. YourdnaPortal didn't give it to me but I see that in Sequencing I have several T/T of HERC2 although I don't know which one.

Genotype: TT
Gene: HERC2

People with your genotype are four times more likely to have blond hair and blue eyes

People with blond hair have low levels of the dark pigment eumelanin. Ranging from platinum, strawberry and sandy blond. Red and fair hair is found mainly in the North West and North East of Europe above the 35th parallel.

Also my father got this one in YourdnaPortal, I don't get it in Sequencing he does appear in Sequencing

Genotype: GT
Gene: LOC105370627

People with your genotype have one copy of this variant for blond hair.

People with blond hair have low levels of the dark pigment eumelanin. Ranging from platinum, strawberry and sandy blond. Red and fair hair is found mainly in the North West and North East of Europe above the 35th parallel.

My father also gets the latter in addition to YourdnaPortal at Sequencing and I don't get it at either company.

Grace O'Malley

12-01-2021, 01:34 PM

My father has also obtained these results, I don't know exactly which marker he must be referring to. YourdnaPortal didn't give it to me but I see that in Sequencing I have several T/T of HERC2 although I don't know which one.

My father also gets the latter in addition to YourdnaPortal at Sequencing and I don't get it at either company.

Thanks for that. I've just looked at their traits and these are some of the ones I get.

https://i.imgur.com/fLnTMJA.png

https://i.imgur.com/pPXxc5N.png

https://i.imgur.com/AUx8EIa.png

https://i.imgur.com/2gawVUC.png

Gallop

12-02-2021, 06:41 PM

Here is one from the La Loma del Puerco (I7162)for blue eye sample that I got before they removed that application for old samples.
In the screenshot there are more bookmarks if anyone wants to try them.

https://1.bp.blogspot.com/-Yyu1dJ0wbQM/X0W0hc8nbUI/AAAAAAAAEac/F7hvlpFQZXEPmjy0hAorD-1pooVmwIbgQCLcBGAsYHQ/s614/kitBronzeAgeLomaPuerco.jpeg

rs7183877 (CC) Blue eyes

Here are more markers from La Loma del Puerco if anyone wants to try them.
https://1.bp.blogspot.com/-b0ixVi1-g2I/X0ZWkaPnTJI/AAAAAAAAEeg/5nSBqeFvnnk0VsfPLHEpH600xRC72Y8NwCLcBGAsYHQ/s5453/SNPlomadelpuerco.jpeg

This marker is obtained by my father and me.

15 28365733 HERC2 rs7183877 C/C

https://1.bp.blogspot.com/-cAAF8gC2OH0/Xi96FiKcoeI/AAAAAAAACis/el8BUlsKdechveAr_L46lk-52_nZqydGwCLcBGAsYHQ/s1600/vasconesVasconia.jpeg
https://1.bp.blogspot.com/-LmTvaUt7k18/Xi96ctlSj0I/AAAAAAAACjY/ZbwRddca6Oo_kjGWp-rGcgTs1sW_oPC7wCLcBGAsYHQ/s1600/ligeropelo.jpeg

This marker is obtained by my father and not by me.
14 92773663 SLC24A4 rs12896399 G/T

https://1.bp.blogspot.com/-prf7oUHlOLg/Xi96QaAUdZI/AAAAAAAACi8/knAR73Aopsw4zBd5508473t2Ow1OsBReQCLcBGAsYHQ/s1600/blueeyes.jpeg

Father
15 28344238 OCA2 rs7495174 A/A
Mine
15 28344238 OCA2 rs7495174 A/G
I guess I am recessive here.

https://1.bp.blogspot.com/-JdNuUW46BUY/Xi96Nm_NEGI/AAAAAAAACi4/R9FVjE9UM9AFC-2clMwDzrbd7bpsWePXgCLcBGAsYHQ/s1600/blueeye2.jpeg

Father
15 2848888 HERC2 rs8028689 T/T
I don't get it

In case anyone wants to try some more markers from the Vascona sample, here they are:

https://1.bp.blogspot.com/-4O706rgCLkw/Xi96X4FH5SI/AAAAAAAACjM/8IcwMbRH3qETmPf8R8DprsExTHSeyy_pgCLcBGAsYHQ/s1600/darkereyecolor2jpeg..jpg
https://1.bp.blogspot.com/-4O706rgCLkw/Xi96X4FH5SI/AAAAAAAACjM/8IcwMbRH3qETmPf8R8DprsExTHSeyy_pgCLcBGAsYHQ/s1600/darkereyecolor2jpeg..jpg
https://1.bp.blogspot.com/-MVdaiacUXPU/Xi96gQoOVfI/AAAAAAAACjg/o9wMXGdFDWQRLH6btP19h2yw-iMoSgw3gCLcBGAsYHQ/s1600/MEDICAOJOSMARRONES.JPEG
https://1.bp.blogspot.com/-YXtR9t750HA/Xi96khttBbI/AAAAAAAACjo/KsN1u547mdwC03lPsU7My_mCQm29UN9WwCLcBGAsYHQ/s1600/pielclara.jpeg
https://1.bp.blogspot.com/-XVlAeE0u_hE/Xi96Ie10ktI/AAAAAAAACiw/HuCqDen2nqwdxil_CfXMnl1hbHuHzFpkQCLcBGAsYHQ/s1600/altura.jpeg
https://1.bp.blogspot.com/-Ly-RvxZUoy0/Xi96VoxmeNI/AAAAAAAACjI/a-PYsltrf7kQIz_s3wA3k3zfBFrJ7LcxgCLcBGAsYHQ/s1600/curlierhair.jpeg
https://1.bp.blogspot.com/-C53VBIgqE3A/Xi96aI3a3fI/AAAAAAAACjQ/6upcDsmW7QQchztDUxl1pI-Y9WiahWciQCLcBGAsYHQ/s1600/darkerskincolor.jpeg

From the Vascones I get the two identical rs light skin and dark skin, my father only gets light skin.

Go and go with the Vascones :)

Insuperable

12-02-2021, 06:46 PM

A/A on both. I am black haired.

https://i.postimg.cc/7L12cZqz/Untitled.png

Cybele

12-03-2021, 12:30 AM

TPCN2 rs35264875 68846399 A / A
TPCN2 rs3829241 68855363 not genotyped

I have darker hair color. 23andme estimates dark blond hair at 14% and light blond hair at 2%.

Different lighting conditions
https://i.imgur.com/TMDiKky.png
https://i.imgur.com/jp1edwN.png

Gallop

12-03-2021, 02:47 PM

I have checked them for both in Sequencing.

Father

Chr 11 Position 68855363 rs3829241 G/A
Chr 11 Position 68846399 rs35264875 A/T

Mine

rs3829241 G/G
rs35264875 (No results found)

Results from my father with screenshot, it is heavy at times but I like to be in my line of seriousness with my results publications.

https://blogger.googleusercontent.com/img/a/AVvXsEhh2LGSdM-CTm0cjdQe_0fJxskCrdJy-rBBWCPLAzCQJ5krAkK8GHSv0dXUFsO1dp6dH1QXEOylkyuAdyM uQAR2S160y6TG9GfA1fMByonKNqucv9ouHgbV5-owuh4QNRADE6q4ORvUUoy_dyqX8JwkS7Hk_iPBBTmzjmKcLdla I6bWTBmE57iDKOgZ=s741
https://blogger.googleusercontent.com/img/a/AVvXsEig3z4_Gz53z1bj15OL_2Gaoddi8Iefn2A8uiRB_iawYk HQq6fmSMbFgPrmy-5IHE04acKANJHLvuSCtrz-lH6Nbha62Hgi4-87zDLqqFcHZCFRLw_cwTOXV_eNVIjrcMleo39O7HMjG70l7pdn WVQPCalXsmdamTMvH5Rw-NaAGXEYUptOyGNFfgEC=s713

https://1.bp.blogspot.com/-euekmTYm66Q/YDrTXWPCZDI/AAAAAAAAF78/6aWA8hh3exsroh9wrk28X2P_q5U_oHDdACLcBGAsYHQ/s1297/Cabellorubio.jpeg

https://1.bp.blogspot.com/-G4BeQuvFKZM/YDrTYkCcJeI/AAAAAAAAF8A/7leaABjd3nI_VreCkIbfz-py__NEA0jmgCLcBGAsYHQ/s1294/Cabellorubio2.jpeg

Roy

12-04-2021, 10:41 PM

Well A is the blond haired snp and you carry one on that. The older versions of 23&Me was better in my view because they tested a lot more snps.

Why did they start testing less SNPs?

bvnny

12-04-2021, 11:23 PM

rs3829241 not genotyped

rs35264875 A/A

Since rs35264875 T/T seems to actually be the one correlated with blonde hair, mine seems to be on point, considering my eyes are dark-brown, my hair is dark-brown, my facial hair is dark-brown and my body hair is also dark-brown.

Roy

12-05-2021, 01:07 PM

rs35264875 T/T
rs3829241 not genotyped

My hair is middle brown.

Gergő Marosvári

12-05-2021, 02:41 PM

From YourDNAPortal:

Blond Hair and Blue Eyes
Genotype: TT
Gene: HERC2
People with your genotype are four times more likely to have blond hair and blue eyes

Blond Hair
Genotype: CT
Gene: KITLG
People with your genotype are two times more likely to have blond hair.

Blond Hair, Lighter Hair
Genotype: GT
Gene: LOC105370627
People with your genotype have one copy of this variant for blond hair.

Roy

12-08-2021, 02:04 PM