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Phylogeography of R1a1 Y-chromosomal haplogroup and genetic history of Indo-Europeans. V. A. Stepanov, V. N. Kharkov Institute for Medical Genetics, Tomsk, Russian Federation.
Recent discussion of the prehistoric spreading of the Indo-European language group has generally concentrated on two alternative hypotheses: so-called “Kurgan Culture” hypothesis, which places the homeland of proto-Indo-Europeans to the Steppe of Eastern Europe, and alternative hypothesis of the spread of farmers from the Near East (Anatolia) to Europe in the Neolithic times. Y-chromosomal haplogroup R1a1, lineage is thought to have originated in the Eurasian Steppes north of the Black and Caspian Seas, seems to be associated with the Kurgan culture. Three geographic areas with the highest frequency of R1a1 haplogroup were revealed: Eastern Europe; Southern Siberia and Hindustan where the highest diversity of microsatellite haplotypes was observed. Phylogenetic analysis of microsatellite haplotypes demonstrates the presence of three corresponding major clusters with the age of the generation of haplotytic diversity of 7.2-12.5 ky. The highest diversity in Hindustani is related to the presence of haplotypes of Indo-Pakistani and Southern Siberian clusters in the population from India and Pakistan, probably due to relatively recent migrations from Central Asia. The age of the cluster admittedly brought to Hindustan from Central Asia / Southern Siberia is 3,9 +/- 1,3 ky. Probably, the primary center of the generation of diversity and expansion of R1a1a was the territory of the Eastern European Steppe. With the spread of of R1a1 carriers, secondary centers of genetic diversity and population expansions were formed in the Southern Siberia and Hindustan.
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Estimating a date of mixture of ancestral South Asian populations. P. Moorjani1,2, N. Patterson2, P. Govindaraj3, L. Singh3,4,5, K. Thangaraj3,5, D. Reich1,2,5 1) Dept Gen, Harvard Medical School, Boston, MA; 2) Broad Institute, Cambridge, MA; 3) Centre for Cellular and Molecular Biology, Hyderabad, India; 4) Genome Foundation, Hyderabad, India; 5) These authors co-directed the project.
Linguistic and genetic studies have shown that most Indian groups have ancestry from two genetically divergent populations, Ancestral North Indians (ANI) and Ancestral South Indians (ASI). However, the date of mixture still remains unknown. We analyze genome-wide data from about 60 South Asian groups using a newly developed method that utilizes information related to admixture linkage disequilibrium to estimate mixture dates. Our analyses suggest that major ANI-ASI mixture occurred in the ancestors of both northern and southern Indians 1,200-3,500 years ago, overlapping the time when Indo-European languages first began to be spoken in the subcontinent. These results suggest that this formative period of Indian history was accompanied by mixtures between two highly diverged populations, although our results do not rule other, older ANI-ASI admixture events. A cultural shift subsequently led to widespread endogamy, which decreased the rate of additional population mixtures.
The Y-DNA of Tarim Basin mummies associated with the Indo-European speaking Tocharians.
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Fifteen individuals' AMG amplicons were obtained from the 20 Xiaohe individuals (whose mtDNA was successfully amplified), among which seven individuals were identified as male and eight as female. The Y chromosome haplogroup of the seven males were all assigned to haplogroup R1a1a through screening the Y-SNPs at M89, M9, M45, M173 and M198 successively. Haplogroup R1a1a is widely distributed in Eurasia: it is mainly found in Eastern Europe, Central Asia, South Asia, Siberia, ancient Siberia, but rare in East Asia