You've been lied to about Globular Amphora Culture

Quote:

---

Originally Posted by Vessna

Only that he’s not Uralid. Your prediction was incorrect.

---

Maybe he is mixed Uralid + some European type, and the combination is giving him overall more European look.

Quote:

---

Originally Posted by Live The Magic

Maybe he is mixed Uralid + some European type, and the combination is giving him overall more European look.

---

his result isnt even uralid, but a mix of uralid + european
Attachment 148673Attachment 148673

In the time I've sold trait predictor reports and the executable, I've never encountered a reaction as crazy as this. :picard2:

Imagine trying to unaryanize the GAC.

Quote:

---

Originally Posted by AndreiDNA

his result isnt even uralid, but a mix of uralid + european
Attachment 148673Attachment 148673

In the time I've sold trait predictor reports and the executable, I've never encountered a reaction as crazy as this. :picard2:

---

Typical sequence- gaslight first, call crazy later. You admitted in DM that mtebid prediction was incorrect. Not even going to waste my time further.

Conclusion: AndreiDNA and his tool sucks.

Quote:

---

Originally Posted by Vessna

I’m not sure why you’re accusing me of lying. My 23andMe report literally states that my genetics make me “most likely to have lighter skin.” It assigns a combined 71% probability to very fair and moderately fair skin, 25% to light beige skin, and only 3% to olive skin.

That’s why I said 23andMe was more accurate in my case. I’m fair-skinned and burn easily. We can disagree about which model performs better overall, but my interpretation of my own report is consistent with the results shown.

https://i.ibb.co/HLYnDHmd/IMG-5958.jpg

---

That exact skin tone prediction is very common among 23andme customers of European ancestry. Just because it is accurate in your case doesn’t discount the large number of customers with darker skin than you who are also predicted as 39% very fair.

Check here for examples:
https://www.reddit.com/r/23andme/com...ame_skin_tone/

There is currently no ideal skin pigmentation prediction tool available.

Quote:

---

Originally Posted by Tilaratch

That exact skin tone prediction is very common among 23andme customers of European ancestry. Just because it is accurate in your case doesn’t discount the large number of customers with darker skin than you who are also predicted as 39% very fair.

Check here for examples:
https://www.reddit.com/r/23andme/com...ame_skin_tone/

There is currently no ideal skin pigmentation prediction tool available.

---

And that’s fine but his tool predicted over 90% chance of olive skin. That’s a large discrepancy.

I checked HIrisPlex for my case and case of few other people and it was 100% of time correct.

Quote:

---

Originally Posted by ~Elizabeth~

Conclusion: AndreiDNA and his tool sucks.

---

What Vessna really looks like:

https://img.magnific.com/free-photo/...rid&w=740&q=80

Ive said a long time ago this guy was lame and gay.

Quote:

---

Originally Posted by ChatGPT

What Vessna really looks like:

https://img.magnific.com/free-photo/...rid&w=740&q=80

Ive said a long time ago this guy was lame and gay.

---

Under his tool samples with heavy NW euro ancestry like British, Scandinavians, and Finns tend to strongly score white on average. Balto-Slavs are more variable. In that population sense it is not surprising that Vessna as a Belorussian might strongly score olive. There are NW Europeans who have darker skin than Vessna but nevertheless score white with AndreiDNA’s tool. Since skin pigmentation is possibly the most polygenic it might reflect genetic cluster more and individual appearance less than other predictions.

Quote:

---

Originally Posted by Tilaratch

Under his tool samples with heavy NW euro ancestry like British, Scandinavians, and Finns tend to strongly score white on average. Balto-Slavs are more variable. In that population sense it is not surprising that Vessna as a Belorussian might strongly score olive. There are NW Europeans who have darker skin than Vessna but nevertheless score white with AndreiDNA’s tool. Since skin pigmentation is possibly the most polygenic it might reflect genetic cluster more and individual appearance less than other predictions.

---

The reason Vessna scores olive for skin color is because of her HERC2 genotype. If she was homozygous there, instead of heterozygous, she'd score white skin.
HERC2 is strongly tied to skin color by GWAS. It's one of the most reliable ways of predicting skin shade in europeans, who pretty much unanimously have derived SLC24A5 and SLC45A2. But try explaining that to her... Her goal is badmouthing my tool, that's the reason she purchased the reports in the first place. She and her buddies here dont GAF about the genetics of skin color.

Quote:

---

Originally Posted by AndreiDNA

The reason Vessna scores olive for skin color is because of her HERC2 genotype. If she was homozygous there, instead of heterozygous, she'd score white skin.
HERC2 is strongly tied to skin color by GWAS. It's one of the most reliable ways of predicting skin shade in europeans, who pretty much unanimously have derived SLC24A5 and SLC45A2. But try explaining that to her... Her goal is badmouthing my tool, that's the reason she purchased the reports in the first place. She and her buddies here dont GAF about the genetics of skin color.

---

HERC2 is the gene associated with eye colour, not skin colour
SNPs, rs916977 and rs12913832

I am heterozygous for both of these SNPs
As Vessna has hazel-green eyes I'd imagine she would be heterozygous for these SNPs too
It wouldn't affect her skin colour

SLC24A5 and SLC45A2 are the genes associated with skin colour....the derived SNPs give Europeans light skin

Quote:

---

Originally Posted by Mopi of the Julii

HERC2 is the gene associated with eye colour, not skin colour
SNPs, rs916977 and rs12913832

I am heterozygous for both of these SNPs
As Vessna has hazel-green eyes I'd imagine she would be heterozygous for these SNPs too
It wouldn't affect her skin colour

SLC24A5 and SLC45A2 are the genes associated with skin colour....the derived SNPs give Europeans light skin

---

go through these GWAS studies.
and type in "HERC2" into "Mapped Gene"
https://www.ebi.ac.uk/gwas/efotraits/OBA_VT0002095

They very much do impact skin color. One of the biggest contributors to it in fact.
Attachment 148674

Quote:

---

Originally Posted by Mopi of the Julii

HERC2 is the gene associated with eye colour, not skin colour
SNPs, rs916977 and rs12913832

I am heterozygous for both of these SNPs
As Vessna has hazel-green eyes I'd imagine she would be heterozygous for these SNPs too
It wouldn't affect her skin colour

SLC24A5 and SLC45A2 are the genes associated with skin colour....the derived SNPs give Europeans light skin

---

Aside from SLC45A2, SLC24A5, HERC2 and OCA2, there are actually a lot of other genes that contribute to skin tone.
In case you didn't know. KITLG, TYRP1, ASIP, IRF4 are also big contributors to skin tone.

Quote:

---

Originally Posted by AndreiDNA

go through these GWAS studies.
and type in "HERC2" into "Mapped Gene"
https://www.ebi.ac.uk/gwas/efotraits/OBA_VT0002095

They very much do impact skin color. One of the biggest contributors to it in fact.
Attachment 148674

---

So, what you're saying is any European without blue eyes (ie not homozygous for HERC2 blue eyed SNPs) has "Olive Skin"

Just from observation of people that can't be correct

Maybe heterzygous SNPs for HERC2 have a v slight darkening affect on skin tone...

Quote:

---

Originally Posted by Mopi of the Julii

So, what you're saying is any European without blue eyes (ie not homozygous for HERC2 blue eyed SNPs) has "Olive Skin"

Just from observation of people that can't be correct

Maybe heterzygous SNPs for HERC2 have a v slight darkening affect on skin tone...

---

no. It is possible to score white, and even palest skin tone with my tool while having hetero HERC2. My tool's skin color prediction takes SLC24A5, SLC45A2, SLC24A4, HERC2, OCA2, ASIP, TYRP1, IRF4, and even MC1R into account. There's many combinations that can yield pale skin with darker eyes.

Quote:

---

Originally Posted by AndreiDNA

The reason Vessna scores olive for skin color is because of her HERC2 genotype. If she was homozygous there, instead of heterozygous, she'd score white skin.
HERC2 is strongly tied to skin color by GWAS. It's one of the most reliable ways of predicting skin shade in europeans, who pretty much unanimously have derived SLC24A5 and SLC45A2. But try explaining that to her... Her goal is badmouthing my tool, that's the reason she purchased the reports in the first place. She and her buddies here dont GAF about the genetics of skin color.

---

HERC2 affects primarily eye color, skin pigmentation is influenced by multiple genes. If HERC2 was solely responsible most brown eyed Europeans would have darker skin which obviously isn’t true. There are people like my husband who are homozygous for HERC2 but their skin is darker and tans well.

Quote:

---

Originally Posted by Vessna

HERC2 affects primarily eye color, skin pigmentation is influenced by multiple genes. If HERC2 was solely responsible most brown eyed Europeans would have darker skin which obviously isn’t true. There are people like my husband who are homozygous for HERC2 but their skin is darker and tans well.

---

yeah right. read my other replies. HERC2 isn't the single biggest factor in my trait predictor's skin color panel. It's just one of the genes that contribute. There are plenty of cases where folks score palest or white skin tone with my tool with darker eyes

Attachment 148675
some examples of globular amphorans that score palest or white skin tone while being heterozygous for HERC2 (hazel eye prediction)

Quote:

---

Originally Posted by AndreiDNA

yeah right. read my other replies. HERC2 isn't the single biggest factor in my trait predictor's skin color panel. It's just one of the genes that contribute. There are plenty of cases where folks score palest or white skin tone with my tool with darker eyes

---

You stated the reason I scored olive skin with your tool was because I am heterozygous for HERC2

Quote:

---

Originally Posted by Vessna

You stated the reason I scored olive skin with your tool was because I am heterozygous for HERC2

---

yes, thats the biggest reason.
If you didnt have derived SLC24A5, SLC45A2, you would've scored light or dark brown. Out of genotypes that contribute to skin color, SLC45A2, SLC24A5, and OCA2/HERC2 had the biggest impact on you scoring olive skin.
Think of this. Spaniards, Italians, Turks, Georgians, they're olive skinned right? Well guess what. They have the same genotype as you. Practically every west eurasian aside from peninsular arabs has derived SLC45A2 and SLC24A5. The thing that sets them apart from northern europeans, skin color wise, is exactly OCA2/HERC2. There's other genes that contribute that i listed earlier, but HERC2/OCA2 is the biggest influencer in this regard. How is the tool supposed to know you're not a Spaniard? When your genotypes are typically spanish...

Quote:

---

Originally Posted by AndreiDNA

yes, thats the biggest reason.
If you didnt have derived SLC24A5, SLC45A2, you would've scored light or dark brown. Out of genotypes that contribute to skin color, SLC45A2, SLC24A5, and OCA2/HERC2 had the biggest impact on you scoring olive skin.
Think of this. Spaniards, Italians, Turks, Georgians, they're olive skinned right? Well guess what. They have the same genotype as you. Practically every west eurasian aside from peninsular arabs has derived SLC45A2 and SLC24A5. The thing that sets them apart from northern europeans, skin color wise, is exactly OCA2/HERC2. There's other genes that contribute that i listed earlier, but HERC2/OCA2 is the biggest influencer in this regard. How is the tool supposed to know you're not a Spaniard? When your genotypes are typically spanish...

---

There are millions of pale skinned Europeans with brown eyes. If HERC2 heterozygosity or a brown eye genotype were enough to predict olive skin then a large portion of Eastern/Central/Northern Europeans would be olive skinned which obviously isn't the case. As I mentioned before, I do not have olive skin. I have to wear protective clothing and layers of sunscreen when I am outside. I might get a little color but burn over and over again if not protected. That's an objective finding, not some abstract. I posted images that you conveniently ignored.

Quote:

---

Originally Posted by Vessna

There are millions of pale skinned Europeans with brown eyes. If HERC2 heterozygosity or a brown eye genotype were enough to predict olive skin then a large portion of Eastern/Central/Northern Europeans would be olive skinned which obviously isn't the case.

---

once again, you're ignoring the impact of other genes. A couple of posts above i showed globular amphora results with my trait predictor. Light skin, such as pale or white, is quite common in Europeans in combination with brown or hazel eyes. You're taking things to an extreme. I say "HERC2 contributes to skin color and is often the difference between white vs olive skin" and you take it to "Its impossible to have white skin if you carry ancestral HERC2".

Quote:

---

Originally Posted by AndreiDNA

once again, you're ignoring the impact of other genes. A couple of posts above i showed globular amphora results with my trait predictor. Light skin, such as pale or white, is quite common in Europeans in combination with brown or hazel eyes. You're taking things to an extreme. I say "HERC2 contributes to skin color and is often the difference between white vs olive skin" and you take it to "Its impossible to have white skin if you carry ancestral HERC2".

---

But that is exactly what YOU are implying - your tool predicted over 95% probability of olive skin in my case because of HERC2 heterozygosity, despite me carrying only one ancestral allele. Make it make sense.

Quote:

---

Originally Posted by Vessna

But that is exactly what YOU are implying - your tool predicted over 95% probability of olive skin in my case because of HERC2 heterozygosity, despite me carrying only one ancestral allele. Make it make sense.

---

Ok.
You have:
HERC2 - rs916977 1
^ the average northern european has 2 derived variants here
HERC2 - rs12913832 1
HERC2 - rs1129038 1
^these two are in a linked region, and some northern euros have heterozygous genotype, like you. most have 2 though. However in med countries, heterozygous genotype is the most common here
HERC2 - rs1667394 1
^The average European (including southern europeans) has 2 derived variants here.
OCA2 - rs4778138 : 1
^The average northern europeans has 2 derived variants here
So your HERC2 profile is pretty southern.

you also have:
ASIP - rs1015362 2
ASIP - rs4911414 0
ASIP - rs6142129 0

Which is quite "ancestral" or dark by average euro standards. This is another factor that predisposes you to olive, rather than white skin tone.

You do have this:
SLC45A2 - rs28777 2
SLC45A2 - rs16891982 2
SLC45A2 - rs28117 2
~SLC45A2 - rs4049255 2
~SLC45A2 - rs35401 2
SLC24A5 - rs1426654 2
Which prevents you from scoring stuff like light brown skin or dark brown skin tone.

Then you have this:
IRF4 - rs12203592 0
If you had derived variants here, like many NW europeans do, it would've led to a lighter skin shade prediction, increasing your odds of white skin. But you don't have any derived variants here.

Then you have:
KITLG - rs642742 2
KITLG - rs114873 2
KITLG - rs12821256 0

Which once again is the typical genotype for a Eurasian. Most folks from Spain to China have this genotype.

You also have:
TYRP1 - rs1408799 2
TYRP1 - rs683 2
TYRP1 - rs16929340 2
TYRP1 - rs1408794 2

Which is typical of NE europeans, but doesn't make a big impact on anything other than eye color.

Finally you have no derived MC1R variants, which could shift your skin color result to be white or palest, rather than Olive.

Basically you have all the variants for darker skin pigmentation in a European context, but have all the variants for lighter skin pigmentation in a West Eurasian/Eurasian context. Hence why the tool predicted you to have olive skin, like a southern european. It's what your genotypes suggest.

Quote:

---

Originally Posted by AndreiDNA

yes, thats the biggest reason.
If you didnt have derived SLC24A5, SLC45A2, you would've scored light or dark brown. Out of genotypes that contribute to skin color, SLC45A2, SLC24A5, and OCA2/HERC2 had the biggest impact on you scoring olive skin.
Think of this. Spaniards, Italians, Turks, Georgians, they're olive skinned right? Well guess what. They have the same genotype as you. Practically every west eurasian aside from peninsular arabs has derived SLC45A2 and SLC24A5. The thing that sets them apart from northern europeans, skin color wise, is exactly OCA2/HERC2. There's other genes that contribute that i listed earlier, but HERC2/OCA2 is the biggest influencer in this regard. How is the tool supposed to know you're not a Spaniard? When your genotypes are typically spanish...

---

Maybe the issue is that the tool just isn't as accurate?
How is the tool supposed to know that an "olive skinned" blue eyed Spaniard isn't a Russian, or a blue eyed Turk isn't a Swede? Does nonancestral HERC2 makes them Northern European?

Quote:

---

Originally Posted by Vessna

Maybe the issue is that the tool just isn't as accurate?
How is the tool supposed to know that an "olive skinned" blue eyed Spaniard isn't a Russian, or a blue eyed Turk isn't a Swede? Does nonancestral HERC2 makes them Northern European?

---

The point is to predict phenotype based on DNA, not on ethnicity. There are Spaniards with a nordic phenotype. The aim of my tool is so that these people get a Nordic phenotype prediction.

Quote:

---

Originally Posted by AndreiDNA

Ok.
You have:
HERC2 - rs916977 1
^ the average northern european has 2 derived variants here
HERC2 - rs12913832 1
HERC2 - rs1129038 1
^these two are in a linked region, and some northern euros have heterozygous genotype, like you. most have 2 though. However in med countries, heterozygous genotype is the most common here
HERC2 - rs1667394 1
^The average European (including southern europeans) has 2 derived variants here.
OCA2 - rs4778138 : 1
^The average northern europeans has 2 derived variants here
So your HERC2 profile is pretty southern.

you also have:
ASIP - rs1015362 2
ASIP - rs4911414 0
ASIP - rs6142129 0

Which is quite "ancestral" or dark by average euro standards. This is another factor that predisposes you to olive, rather than white skin tone.

You do have this:
SLC45A2 - rs28777 2
SLC45A2 - rs16891982 2
SLC45A2 - rs28117 2
~SLC45A2 - rs4049255 2
~SLC45A2 - rs35401 2
SLC24A5 - rs1426654 2
Which prevents you from scoring stuff like light brown skin or dark brown skin tone.

Then you have this:
IRF4 - rs12203592 0
If you had derived variants here, like many NW europeans do, it would've led to a lighter skin shade prediction, increasing your odds of white skin. But you don't have any derived variants here.

Then you have:
KITLG - rs642742 2
KITLG - rs114873 2
KITLG - rs12821256 0

Which once again is the typical genotype for a Eurasian. Most folks from Spain to China have this genotype.

You also have:
TYRP1 - rs1408799 2
TYRP1 - rs683 2
TYRP1 - rs16929340 2
TYRP1 - rs1408794 2

Which is typical of NE europeans, but doesn't make a big impact on anything other than eye color.

Finally you have no derived MC1R variants, which could shift your skin color result to be white or palest, rather than Olive.

Basically you have all the variants for darker skin pigmentation in a European context, but have all the variants for lighter skin pigmentation in a West Eurasian/Eurasian context. Hence why the tool predicted you to have olive skin, like a southern european. It's what your genotypes suggest.

---

My issue isn't that the model predicted olive skin. It's the confidence level. If my actual phenotype doesn't match the prediction, maybe the model is overestimating the predictive value of those variants. I am curious to see what you have for my husband who has darker skin than me.

Quote:

---

Originally Posted by Vessna

My issue isn't that the model predicted olive skin. It's the confidence level. If my actual phenotype doesn't match the prediction, maybe the model is overestimating the predictive value of those variants. I am curious to see what you have for my husband who has darker skin than me.

---

This confidence level is typical with bayesian likelyhood estimates. Have you ever used snipper3? try it, it will give you stuff like "80,000,000 more likely hazel than blue eyes" and such. It uses the same method as my tool's skin color estimate.
I modified the algorithm for eye and hair color, so that it wouldn't give out stuff like "99.5% odds of hazel eyes" for folks like you. I came up with my own mathematical method that still uses bayesian statistics but doesn't lead to a crazy confidence level.