the 1$ illustrativeDNA is here

The 1$ illustrativeDNA is here, introduced by me!

https://andreimix.pythonanywhere.com/

You pay 1$ and upload your raw genome (accepts Myheritage, 23andme, ancestry formats)
Within a minute or so you get your results, based on Eurogenes K36 calculator
Since this is based on eurogenes k36, you will see mostly iron age, bronze age, and modern groups in your results, no neolithic stuff or prior

Pic related is an example of a result.

Make sure you don't upload twice (Don't get inpatient and click on the upload button the second time after clicking on it once) and don't refresh the page once you have clicked to upload. Take a screenshot of the results once they load. They won't be saved anywhere.
Attachment 145304
Attachment 145305

With time, I will be updating it, and adding other features. I plan to add a G25 coordinate simulator to my tool

https://www.theapricity.com/forum/at...d=145315&stc=1

https://i.postimg.cc/SKMnbCmQ/izobrazenie.png

I added a new feature! You can now exclude populations from your result

You updated the site without replying to my message, so here it is:

Quote:

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To avoid needlessly obtaining customers' shipping addresses (since you aren't shipping us anything), you should update your PayPal JS code like this:

Code:

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{  purchase_units: [{ amount: { value: '1.00' } }],
  payment_source: { paypal: { experience_context: { shipping_preference: 'NO_SHIPPING' } } }
}

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I added more samples.
Frankish_Flanders(n4)
Afghanistan_Darra_I_Kur_MBA
DA230_Karluk(n1)
Gaulish(n2)
Saxon_Kent(n2)
Ingria_IA(n3)

del

Added more samples and also added population lookup. You can now look up the populations that show up in your result to get a better picture of what each of them represent.

i just payed and did step 2.
Still loading is probably stuck. tried to reload the page and nothing.

What now?

Quote:

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Originally Posted by AndreiDNA

Added more samples and also added population lookup. You can now look up the populations that show up in your result to get a better picture of what each of them represent.

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Did not work. I have the email confirmation that i have payed not the website is buggy.
Could you send me the results per mail?

Quote:

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Originally Posted by Croatian Legend

Did not work. I have the email confirmation that i have payed not the website is buggy.
Could you send me the results per mail?

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I was updating the site when you tried to use it. Should work now.

Attachment 145443
My result. I also added HG/Farmer breakdowns. This was the last update I did today.

Very good

https://i.postimg.cc/qMBFJFtX/123.png

https://i.postimg.cc/XJ8gtVgW/Farmer-HG.png

Results from my MyHeritage file, which is the one I use for qpAdm on IllustrativeDNA. For some reason I can't upload my merged file for qpAdm.

Attachment 145444

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I added HG& Farmer based coordinates to my 1$ illustrativeDNA
You can use them to compare yourself with the samples that are present on the lookup page using vahaduo.

Price is still only 1$
Attachment 145461Attachment 145462Attachment 145463

simple vahaduo run on myself:
Distance to: Result
3.85502270 WhiteCroat(n1)
6.38070529 King_Ladislaus_1(Arpad)
8.24686607 East_Finnish(Modern)
26.58321463 NorthMacedonia_IA(n4)
33.22682049 Hittite(n4)

Target: Result
Distance: 256.6797% / 2.56679702
73.2 WhiteCroat(n1)
26.8 East_Finnish(Modern)

https://i.postimg.cc/rpZNfjGp/image.png

I added a modern population section and updated to price to 2.50$
Attachment 145475

https://youtu.be/dQQMhqCb1rQ

Results with the new features:

Attachment 145526

Coordinates:

Gannicus,15.01,17.39,17.3,5.1,41.37,2.13,0.0,0.0,1 .65,0.0,0.0,0.0,0.05

Attachment 145527
Does your result look like this?
This is the default result that happens when you upload a file of a valid format (.txt or .csv) but without any SNP data.
It doesn't trigger an outright error that would crash the session early on but this result is not an actual result.
I've been checking the server logs and noticed that many people are getting this. Feel free to email me with your raw genomes in case this is what your result looked like.
dusqcomputer‪@gmail.com‬

https://i.ibb.co/C30mbckV/Andrei-DNA.png

https://i.ibb.co/rf61mpP3/Andrei-DNA-2.png

https://i.ibb.co/8406qPc1/Andrei-DNA-3.png

Guess my ethncity.

https://i.postimg.cc/LsMx0gJ1/Screen...-Optimizer.png

https://i.postimg.cc/vTDh6WNS/Screen...-Optimizer.png

https://i.postimg.cc/xjFtV4XW/Screen...-Optimizer.png

Clustering of humans, apes, Neanderthals, and Denisovans based on f2 statistics. FST becomes inflated in lineages with very low heterozygosity, such as Neanderthals, Denisovans, and apes, because it is normalized by within-population diversity, making it poorly suited for phylogenetic clustering in this context. In contrast, f2 directly measures shared genetic drift and is far less sensitive to low heterozygosity, producing more stable and interpretable relationships.
Attachment 145744

Quote:

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Originally Posted by AndreiDNA

Clustering of humans, apes, Neanderthals, and Denisovans based on f2 statistics. FST becomes inflated in lineages with very low heterozygosity, such as Neanderthals, Denisovans, and apes, because it is normalized by within-population diversity, making it poorly suited for phylogenetic clustering in this context. In contrast, f2 directly measures shared genetic drift and is far less sensitive to low heterozygosity, producing more stable and interpretable relationships.
Attachment 145744

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This clustering makes no sense because according to it Neanderthals and Denisovans are closer to apes than to humans.

BTW - AV2 is not an Early Medieval Pole, this sample is from Hungary.

Quote:

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Originally Posted by Peterski

This clustering makes no sense because according to it Neanderthals and Denisovans are closer to apes than to humans.

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The thing is according to Fst and F2, they are.
That happens because most ancient-DNA datasets are built from SNP panels, such as the 1240k panel, and the SNPs are chosen because they are polymorphic among modern humans, especially West Eurasians. Sites where modern humans differ from the ancestral state are overrepresented, while Sites where archaic hominins or apes differ from each other are underrepresented. This causes apes, neanderthals, and various other non humans to cluster tightly with one another in F2, because they are sharing many of the same ancestral alleles.
If I added wolf to this it'd also cluster with apes and neanderthals. Same with any other non human.

But i dont really have to explain this to you and everybody else, do I? My post is a bit of an IQ test isnt it.

Okay, I get it. I wasn't aware that the 1240K panel is useless for archaic hominins as I don't really deal with archaic DNA.

And how do you explain the fact that when you upload apes to GEDmatch, they score like Sub-Saharans in calculators?
(although the number of SNPs used in calculation is really small)
I didn't test it myself but few years ago someone posted the results of apes in Eurogenes K13/K15 calculators and Oracles.
Neanderthals and Denisovans also score SSA in Eurogenes calculators.

Ok I just checked it.

Chimp_HO from Reich's dataset in Eurogenes K36:

Sample Chimp_HO.txt
Amerindian 0.00
Arabian 0.00
Armenian 0.00
Basque 0.00
Central African 0.00
Central Euro 0.00
East African 0.00
East Asian 0.00
East Balkan 0.00
East Central Asian 0.00
East Central Euro 0.00
East Med 0.00
Eastern Euro 0.00
Fennoscandian 0.00
French 0.00
Iberian 0.06
Indo-Chinese 0.00
Italian 0.00
Malayan 0.00
Near Eastern 0.00
North African 0.00
North Atlantic 0.51
North Caucasian 0.00
North Sea 0.00
Northeast African 0.00
Oceanian 1.49
Omotic 7.81
Pygmy 80.52
Siberian 0.00
South Asian 0.00
South Central Asian 0.00
South Chinese 1.59
Volga-Ural 0.65
West African 7.38
West Caucasian 0.00
West Med 0.00

Is it because the panel is built especially for Eurasians?

Quote:

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Originally Posted by Peterski

Okay, I get it. I wasn't aware that the 1240K panel is useless for archaic hominis as I don't really deal with archaic DNA.

And how do you explain the fact that when you upload apes to GEDmatch, they score like Sub-Saharans in calculators?
(although the number of SNPs used in calculation is really small)
I didn't test it myself but few years ago someone posted the results of apes in Eurogenes K13/K15 calculators and Oracles.
Neanderthals and Denisovans also score SSA in Eurogenes calculators.

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Since most of these calculators use the same SNPlists as the harvard datasets, they fall victim to the same issue. The big difference, however, is that in my analysis with F2 I selected multiple "non human" anchors, hence why you see the variability even among non humans, why you see denisovans and neanderthals clustering together, and separate from the apes, why you see closely related apes (Chimps and Gorillas) clustering together, rather than - for example, chimps clustering with macaques. The phylo tree I posted really is brilliant. With G25 or GEDmatch calcs, all these apes and archaic humans wouldn't even make a separate clusters with themselves - they'd just plot with Sub Saharans. Thats because GEDmatch calcs and G25 don't anchor archaic hominid or Apes. There are actually some GEDmatch calcs that do anchor archeic humans though, I know some of the MDLP ones do. These calculators are goated. With them you can tell apart blacks and neanderthals. But if you ran a monkey through these calcs it would just score like a neanderthal.

Interesting, I will check which MDLP calcs anchor archaic humans.

Attachment 145746

Attachment 145747

https://youtu.be/lR-6IUIuSnE

Attachment 145820

Very consistent with most of my results.

Thanks for making this Andrei

Attachment 146014
Modeling various eastern european populations using the coordinates on my andreimix lookup page
https://andreimix.pythonanywhere.com/lookup

https://youtu.be/pabP836O0o4