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Thread: Not ALL neanderthal genes make stronk

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    Default Not ALL neanderthal genes make stronk

    http://dienekes.blogspot.com/2013/12...etes-risk.html


    Performing genetic studies in multiple human populations can identify disease risk alleles that are common in one population but rare in others1, with the potential to illuminate pathophysiology, health disparities, and the population genetic origins of disease alleles. Here we analysed 9.2 million single nucleotide polymorphisms (SNPs) in each of 8,214 Mexicans and other Latin Americans: 3,848 with type 2 diabetes and 4,366 non-diabetic controls. In addition to replicating previous findings2, 3, 4, we identified a novel locus associated with type 2 diabetes at genome-wide significance spanning the solute carriers SLC16A11 and SLC16A13 (P = 3.9 × 10−13; odds ratio (OR) = 1.29). The association was stronger in younger, leaner people with type 2 diabetes, and replicated in independent samples (P = 1.1 × 10−4; OR = 1.20). The risk haplotype carries four amino acid substitutions, all in SLC16A11; it is present at ~50% frequency in Native American samples and ~10% in east Asian, but is rare in European and African samples. Analysis of an archaic genome sequence indicated that the risk haplotype introgressed into modern humans via admixture with Neanderthals. The SLC16A11 messenger RNA is expressed in liver, and V5-tagged SLC16A11 protein localizes to the endoplasmic reticulum. Expression of SLC16A11 in heterologous cells alters lipid metabolism, most notably causing an increase in intracellular triacylglycerol levels. Despite type 2 diabetes having been well studied by genome-wide association studies in other populations, analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism.
    Mexicans get more diabetes due to a neanderthal gene, not due to too many carbs in diet as previously thought.
    Out Of Africa Theory is a lie.
    http://www.theapricity.com/forum/sho...88#post3431588
    And a mighty angel took up a stone like a great millstone, and cast it into the sea, saying, Thus with violence shall that great city Babylon be thrown down, and shall be found no more at all.

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    Veteran Member Neanderthal's Avatar
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    Quote Originally Posted by Melonhead View Post
    http://dienekes.blogspot.com/2013/12...etes-risk.html



    Mexicans get more diabetes due to a neanderthal gene, not due to too many carbs in diet as previously thought.
    Complete bullshit. How many Mexicans with white-Neanderthal features do you know or have seen? or how many Mexicans have RH- blood?

    This is dumb people 'science'. The correlation is absolutely stupid, like surveying a bunch of junkies and getting in conclusion that all of them smell like shit, then reasoning all the people who smells like shit are junkies.

    Real reason for diabetes, fatness and weight problems among Mexicans:



    Every fucking tortilla have at least 100 calories, now, in one meal, average Mexican eats about 5 or 6 tortillas, that's 1500 empty calories at day.

    And this:



    This is diabetes bottled.

    Fat Mexicans, stop blaming shit on ancient hominids and drop this crap.
    'It's time to chew ass' - Dick Kickem

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    Johannes factotum
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    It's also linked to Autism/Asperger's.
    Who is rich? He who is happy with what he has - Simeon ben Zoma, Ethics of the Fathers, Talmud, Avot 4:1

    Quote Originally Posted by zhaoyun View Post
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    Quote Originally Posted by Longbowman View Post
    It's also linked to Autism/Asperger's.
    I think we found the explanation for our resident Neanderthal survivor.

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    Quote Originally Posted by Neanderthal View Post
    Complete bullshit. How many Mexicans with white-Neanderthal features do you know or have seen? or how many Mexicans have RH- blood?

    This is dumb people 'science'. The correlation is absolutely stupid, like surveying a bunch of junkies and getting in conclusion that all of them smell like shit, then reasoning all the people who smells like shit are junkies.

    Real reason for diabetes, fatness and weight problems among Mexicans:



    Every fucking tortilla have at least 100 calories, now, in one meal, average Mexican eats about 5 or 6 tortillas, that's 1500 empty calories at day.

    And this:



    This is diabetes bottled.

    Fat Mexicans, stop blaming shit on ancient hominids and drop this crap.
    Yeah, I should specify that in a TINY MINORITY of mexicans, this is the case. It's mainly lean, fit young people with type 2 diabetes that the gene is linked to.

    But I am sure the diet is the biggest issue, and mexicans in general seem to be very skinny til they hit 25 or so then baloon up like crazy, which is no doubt the main problem.

    I love mexican food, but I agree...tortillas are ridiculous waste of calories.
    Out Of Africa Theory is a lie.
    http://www.theapricity.com/forum/sho...88#post3431588
    And a mighty angel took up a stone like a great millstone, and cast it into the sea, saying, Thus with violence shall that great city Babylon be thrown down, and shall be found no more at all.

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    Quote Originally Posted by Longbowman View Post
    It's also linked to Autism/Asperger's.
    I'm pretty sure it's not directly linked to any neanderthal genes, it just occurs in some of the populations that have the highest percentage of them.
    Out Of Africa Theory is a lie.
    http://www.theapricity.com/forum/sho...88#post3431588
    And a mighty angel took up a stone like a great millstone, and cast it into the sea, saying, Thus with violence shall that great city Babylon be thrown down, and shall be found no more at all.

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    Quote Originally Posted by Szegedist View Post
    I think we found the explanation for our resident Neanderthal survivor.
    Why do you hate blond neanderthal Jesus so much?
    Out Of Africa Theory is a lie.
    http://www.theapricity.com/forum/sho...88#post3431588
    And a mighty angel took up a stone like a great millstone, and cast it into the sea, saying, Thus with violence shall that great city Babylon be thrown down, and shall be found no more at all.

  8. #8
    Johannes factotum
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    Quote Originally Posted by Melonhead View Post
    I'm pretty sure it's not directly linked to any neanderthal genes, it just occurs in some of the populations that have the highest percentage of them.
    http://cogsci.stackexchange.com/ques...entific-theory

    Plenty of articles debating it. It makes sense considering what we know of Neanderthal society, or lack of said.
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    Quote Originally Posted by zhaoyun View Post
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    Quote Originally Posted by Longbowman View Post
    http://cogsci.stackexchange.com/ques...entific-theory

    Plenty of articles debating it. It makes sense considering what we know of Neanderthal society, or lack of said.
    Cleveland Mark Blakemore seem to think differently.

    "The race does not go to the beautiful, smartest, most creative, most handsome, strongest or most agile in life. Evolution does not favor the "good" and punish the "bad." You don't understand what is being talked about. It normally goes to tapeworms and parasitic dung eating opportunists who find shortcuts around all of that.

    You must have missed the hardcore scientific evidence that has now spilled out that not only is Homo Sapiens physically smaller in both brain and muscle mass but that every single thing that has been identified as being constructed by him over the past 40,000 years looks like sh*t thrown into a blender while it was turned on.

    His weapons, artwork, culture, crafts and habitations seem like the work of children wherever we have Neanderthals to compare with. Imagine a mob of evil rape mongoloids who have throwing arms like Joe Dimaggio and breeds like locusts. The police, fire and rescue crews can't believe this retarded bitch is killing them from thirty meters away with a rain of spears. After all, these are just retards. Yet every time they try to arrest the evil mob of rape retards a hail of deadly spears cuts them down. Nobody can believe it and when you blink there are hundreds more.

    This is how the Neanderthal felt. He probably could not fathom how a retarded ass-monkey could possibly prevail against him when he had six times their physical strength and ten times their agility as a warrior. It didn't matter. They always attacked in groups at least 300 strong and just turned the air into a rain of spears everywhere you looked. The Neanderthal never had a chance to fight any of these creatures. They were no warriors and they had no honor. They were evil spear-chucking rape retards and nothing could stop them. They swept over Europe like a zombie invasion and their hideous women dropped litters on the ground as they walked behind them. The mighty Neanderthal's only hope to prevail against this demonic horde was to develop air-cooled fan belt fed machine guns and manufacture bullets a thousand rounds a day. Their technology just could not catch up quickly enough to save them from the drooling horde of the rape retard armies."
    'It's time to chew ass' - Dick Kickem

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    Quote Originally Posted by Longbowman View Post
    http://cogsci.stackexchange.com/ques...entific-theory

    Plenty of articles debating it. It makes sense considering what we know of Neanderthal society, or lack of said.
    Social skills = deception skills. Neanderthal skills = do stuff skills. Even though fewer and fewer are needed per capita, at some point someone has to do actually stuff, and it will always be neanderthals. And when society collapses, neanderthals will be survivors and rebuilders.

    I could go into the whole autism and aspergers thing but it's too complicated and boring and pointless to bother.
    Out Of Africa Theory is a lie.
    http://www.theapricity.com/forum/sho...88#post3431588
    And a mighty angel took up a stone like a great millstone, and cast it into the sea, saying, Thus with violence shall that great city Babylon be thrown down, and shall be found no more at all.

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