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There were two migrations out of Africa, the first was F* which gave us the most famous European haplogroups->R1b,R1a,I,J,G and even H (gypsy).
Then there was a much later migration out of Africa, which we can call DE. DE split into E, maybe this happened somewhere in Middle East, but essentially it's not so important. Having E means you are a product of the second migration out of Africa.
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