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Thread: Genetic Structure of Europeans: A View from the North–East

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    Default Genetic Structure of Europeans: A View from the North–East

    Genetic Structure of Europeans: A View from the North–East

    Abstract

    Using principal component (PC) analysis, we studied the genetic constitution of 3,112 individuals from Europe as portrayed by more than 270,000 single nucleotide polymorphisms (SNPs) genotyped with the Illumina Infinium platform. In cohorts where the sample size was >100, one hundred randomly chosen samples were used for analysis to minimize the sample size effect, resulting in a total of 1,564 samples. This analysis revealed that the genetic structure of the European population correlates closely with geography. The first two PCs highlight the genetic diversity corresponding to the northwest to southeast gradient and position the populations according to their approximate geographic origin. The resulting genetic map forms a triangular structure with a) Finland, b) the Baltic region, Poland and Western Russia, and c) Italy as its vertexes, and with d) Central- and Western Europe in its centre. Inter- and intra- population genetic differences were quantified by the inflation factor lambda (λ) (ranging from 1.00 to 4.21), fixation index (Fst) (ranging from 0.000 to 0.023), and by the number of markers exhibiting significant allele frequency differences in pair-wise population comparisons. The estimated lambda was used to assess the real diminishing impact to association statistics when two distinct populations are merged directly in an analysis. When the PC analysis was confined to the 1,019 Estonian individuals (0.1% of the Estonian population), a fine structure emerged that correlated with the geography of individual counties. With at least two cohorts available from several countries, genetic substructures were investigated in Czech, Finnish, German, Estonian and Italian populations. Together with previously published data, our results allow the creation of a comprehensive European genetic map that will greatly facilitate inter-population genetic studies including genome wide association studies (GWAS).
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    Well I can't say for sure but most of those populations can make a tight cluster together so it wouldn't be that suprising.

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    advocating preservation of teh genetic Europe can now be based on these findings

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    Veteran Member Ibericus's Avatar
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    We are a big one family, europeans ,

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    Quote Originally Posted by Toni View Post
    advocating preservation of teh genetic Europe can now be based on these findings
    and i advocate your perservation in teh formaldehyde

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    Senior Member hereward's Avatar
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    Saw this a while ago now. Since joining here, I have always found it strange that you do not have many of the PC plots pinned in the Genetic section, why is this?

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    Quote Originally Posted by Iberia View Post
    We are a big one family, europeans ,

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    Quote Originally Posted by Eldritch View Post
    and i advocate your perservation in teh formaldehyde
    Shut up, Mongol, and go back to your yurta.

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