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Thread: Latin American genetic studies [official archive]

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    Quote Originally Posted by Argentano View Post
    ¿Qué sería "PEL"??

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    Quote Originally Posted by Mr. Wog View Post
    ¿Qué sería "PEL"??
    Peru lima

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    Quote Originally Posted by Argentano View Post
    Peru lima
    Ah, gracias!

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    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243381/

    Native ancestry is associated with optic neuritis and age of onset in hispanics with multiple sclerosis


    Methods
    Data were obtained for 1033 self‐identified Hispanics with MS from four MS‐based registries from four academic institutions across the United States January 2016–April 2017. Multivariate regression models, utilizing genetic ancestry estimates for Native American (NA), African, and European ancestry, were used to assess the relationship between genetic ancestry and ON presentation and age of MS onset, defined as age at first symptom.


    The distribution of genetic ancestry proportions in Hispanics with MS across sites differs. UM, University of Miami, USC, University of Southern California, PR, San Juan MS Center in Puerto Rico; UCSF, University of California, San Francisco.


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    Brazil Recife

    https://www.sciencedirect.com/scienc...665?via%3Dihub

    Methods
    Case–control study. Out of 176 HIV-infected patients recruited in the city of Recife, Northeast Brazil, 67 patients with no immunologic response were the cases and the remaining 109 patients who responded were the controls. A set of 94 selected single nucleotide polymorphisms (SNPs) involved in antiretroviral drugs pharmacodynamic pathways and immune system homeostasis were genotyped, while the remaining 48 were ancestry informative markers (AIMs) for controlling for eventual hidden population structure.

    Results
    Patients’ characteristics
    The individuals in our sample presented a major European ancestry contribution (mean proportion 55.2 ± 18.5%), followed by African (32.3 ± 16.4%) and Amerindian (12.4 ± 10.5%), as expected, due to our previous works with other samples of the same general population.31

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    How much european admixture have the amerindian mexicans?

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    Quote Originally Posted by CostaRicaBall View Post
    How much european admixture have the amerindian mexicans?
    Like 10-30% on that other hand Guatemala has lots of pure Amerindians.

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    So is that is the case, its probably that Mexico is a balanced mestizo country.

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    Quote Originally Posted by CostaRicaBall View Post
    So is that is the case, its probably that Mexico is a balanced mestizo country.
    On average yes but they're exception of spectrums as well.


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    Quote Originally Posted by Mexicano View Post
    Like 10-30% on that other hand Guatemala has lots of pure Amerindians.
    Mexican amerindians can range from 0.5%-30% European.

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