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Received: 12,362 Given: 11,959 |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243381/
Native ancestry is associated with optic neuritis and age of onset in hispanics with multiple sclerosis
Methods
Data were obtained for 1033 self‐identified Hispanics with MS from four MS‐based registries from four academic institutions across the United States January 2016–April 2017. Multivariate regression models, utilizing genetic ancestry estimates for Native American (NA), African, and European ancestry, were used to assess the relationship between genetic ancestry and ON presentation and age of MS onset, defined as age at first symptom.
The distribution of genetic ancestry proportions in Hispanics with MS across sites differs. UM, University of Miami, USC, University of Southern California, PR, San Juan MS Center in Puerto Rico; UCSF, University of California, San Francisco.
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Brazil Recife
https://www.sciencedirect.com/scienc...665?via%3Dihub
Methods
Case–control study. Out of 176 HIV-infected patients recruited in the city of Recife, Northeast Brazil, 67 patients with no immunologic response were the cases and the remaining 109 patients who responded were the controls. A set of 94 selected single nucleotide polymorphisms (SNPs) involved in antiretroviral drugs pharmacodynamic pathways and immune system homeostasis were genotyped, while the remaining 48 were ancestry informative markers (AIMs) for controlling for eventual hidden population structure.
Results
Patients’ characteristics
The individuals in our sample presented a major European ancestry contribution (mean proportion 55.2 ± 18.5%), followed by African (32.3 ± 16.4%) and Amerindian (12.4 ± 10.5%), as expected, due to our previous works with other samples of the same general population.31
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How much european admixture have the amerindian mexicans?
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So is that is the case, its probably that Mexico is a balanced mestizo country.
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