Latin American genetic studies [official archive]

[Tenma de Pegasus]

2019 SAO PAULO RIBEIRAO PRETO

https://www.ncbi.nlm.nih.gov/pubmed/31505868

HLA-G Polymorphisms Are Associated with Non-Segmental Vitiligo among Brazilians

Population Sample

We studied 50 non-segmental vitiligo patients from the Ribeirão Preto region, located in the northern region of the State of São Paulo, southeastern Brazil, and followed up at the Dermatology Outpatient Clinic of the University Hospital of the Ribeirão Preto Medical School, University of Sao Paulo. These individuals, 33 women and 17 men, with ages ranging from 18 to 75 years, filled out a questionnaire, signed an informed consent form and donated a 10-mL blood sample, which was stored in a Vacutainer
® EDTA-containing tube. A total of 393 healthy individuals, 186 women and 207 men, with ages ranging from 18 to 80 years, were selected within the Ribeirão region for the control group and were submitted to the same procedures.

Results

The ancestry background of the vitiligo group was 58.5% European, 29.7% African, and 11.7% Asian/Amerindian (Figure 1). In contrast, the control group’s ancestry background was 72.3% European, 19.9% African, and 7.8% Asian/Amerindian (Figure 1). This indicates a higher African and lower European ancestry among Brazilian vitiligo patients when compared to controls.

Vitiligo is not a good way to measure genetics because it affects more people with african ancestry, blacks have a higher incidence. So the results can appear less euro and more african.

[Tenma de Pegasus]

https://www.nature.com/articles/s41598-019-49611-1

83% Euro seems accurate for Sao Paulo countryside cities. Sao Paulo outside Sao Paulo multicultural rainbow metropolis is a very european area at South Brazil level.

[Tenma de Pegasus]

https://onlinelibrary.wiley.com/doi/...1002/cam4.2434

Self‐Identified African Americans and prostate cancer risk: West African genetic ancestry is associated with prostate cancer diagnosis and with higher Gleason sum on biopsy


AIMs estimates of individual WA, EU, and NA ancestry for 96 self‐identified African American and 59 self‐identified European American patients undergoing standard‐of‐care systematic prostate biopsy. The mean percentage of WA genetic ancestry for the AA men was 80% (SD 12%) and for the EA men was 7% (SD 12%), and the means were significantly different P < .0001. The mean percentage of EA ancestry was 89% (SD 14%) for the EA men and 17% (SD 12%) for the AA men, and the means were significantly different P < .0001. The mean percentage of NA ancestry was 3% (SD 4%) for AA men and 4% (SD 4%) for EA men (no significant difference). NA ancestry was not included in the analyses

So according to this study black americans are 85% african and white americans 94% european on average?

[Tenma de Pegasus]

According to this study Brazil seems 67.5%-70% euro again, like many others before. Seems very plausible.

[Argentano]

Vitiligo is not a good way to measure genetics because it affects more people with african ancestry, blacks have a higher incidence. So the results can appear less euro and more african.

Look again

notice i only highglighted the CONTROL GROUP that is the random group that doesent have Vitiligo.

[Tenma de Pegasus]

Look again

notice i only highglighted the CONTROL GROUP that is the random group that doesent have Vitiligo.

True! You are right.

[Argentano]

BRAZIL SAO PAULO

https://www.nature.com/articles/s41598-019-50362-2#Abs1

Methods
Subjects
We analysed 264 healthy individuals (159 females; 105 males) ascertained at the University of Campinas hospital (UNICAMP, Campinas, São Paulo, Brazil) within the scope of the Brazilian Initiative on Precision Medicine Project (BIPMed; http://bipmed.org). We defined them as the Brazilian-São Paulo sample (BRS). Among them, 202 had information about their state of birth (Supplementary Fig. 27). This study was approved by the Research Ethics Committee of the University of Campinas (UNICAMP, Campinas, São Paulo, Brazil), and we obtained informed consent from all participants who signed a consent form before entering the study. All methods were performed in accordance with the relevant guidelines and regulations.


In order to avoid an excess of subpopulation variation in global and local ancestry comparison, we focused on global ancestry inference at K = 5, which identified the ancestry components from the five continental populations presented in the 1 KGP data (Fig. 1b, Supplementary Fig. 3). The BRS sample showed a high ancestry proportion of the European component (blue; mean = 76.9%; SD = 15.7%), followed by sub-Saharan African (red; mean = 13.8%; SD = 11.6%) and Native-American (green; mean = 7%; SD = 5.6%) components (Supplementary Table 1), which is consistent with previous studies19,20. We also observed that five individuals located between the European and East Asian clusters in PCA had an East Asian component in the admixture plots (Supplementary Fig. 3). Indeed, after this observation, we were able to retrieve some of the surnames of the volunteers, and four of them bore Japanese surnames.



ordered from least euro to most euro. Blue is euro, orange is african green is amerindian and yellow is asian.

[Catarinense1998]

Deleted.

[Adamastor]

Brazilian study about diferents populations. I don't know if it was already posted here. Anyway, I will post it:

It has been posted, this one is very outdated now.

[Argentano]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748312/

METHODS:
This is a multicenter, observational, cross-sectional study with 1564 patients, conducted between August 2011 and August 2014 in 14 public clinics from 10 Brazilian cities. The ethnic aspects of the patients were evaluated using self-reported color-race and genomic ancestry (divided in European, African, and Amerindian). We divided the patients into groups: normal renal function and CKD.

The median EUR ancestry in our sample was 68.0 [30.9], AFR was 16.3 [23.1] and NAM was 10.2 [15.9]. Figure 1 shows the global admixture distribution per individual considering the proportion of EUR, AFR and NAM ancestries and dividing the patients into normal renal function group and CKD group.