Can you drink milk (are you lactose tolerant) ???

[Peterski]

There are two SNPs associated with lactose tolerance in Europeans - rs4988235 and rs182549:

MCM6 contains two of the regulatory regions for LCT, the gene encoding the protein lactase, located in two of the nearby MCM6 introns, rs182549 and rs4988235, approximately 14 kb (-13910) and 22 kb (-22018) upstream of LCT. (...) Mutations in these regions are frequently associated with lactose tolerance into adult life.

I can drink milk so - just as expected - it turns out that I have mutations in both of these regions.

In case of rs182549, C is ancestral allele and T is derived. In rs4988235, A is derived and G ancestral:

Lactose intolerance has primarily been linked to SNPs found in the introns of the MCM6 gene which turn out to have some control over the lactase LCT gene located many thousands of base pairs away.

These SNPs include rs182549 and rs4988235, for which the (T) and (A) alleles, respectively, form a haplotype predicting lactase persistence (thus avoiding lactose intolerance)

I have "CT" alleles at rs182549 and "AG" at rs4988235. One ancestral and one derived allele in each case. Each of these mutations is dominant, so one derived is enough to activate its effects on lactose tolerance.

But I've heard about people who can drink milk and expected to get derived results, but it turned out that they have ancestral alleles. So maybe there are other, still unknown, mutations which have a similar effect.

Is there anyone on Apricity who has "CC" at rs182549 and "GG" at rs4988235 but can still drink milk?

[Ülev]

but I can drink milk directly from cow, "milk" from shops is different thing

[щрбл]

Yes, because I'm not a nigga.

[Prism]

If you're intolerant to lactose you ain't white.

[Poise n Pen]

I think everyone white can drink milk, and even many blacks. Just not many asians.

[DRUM]

CC on rs182549

GG on rs4988235

drink milk without problem

[Linebacker]

My diet consisnts of at least 45% milk,there is an old woman who lives closeby that has cows and when she milks them I buy regularly from her.

[Peterski]

I think everyone white can drink milk

Nope, not everyone - many Europeans are lactose intolerant.

And ancient Europeans who lived before the Bronze Age, most probably could not drink milk at all.

[gültekin]

rs182549 TC
rs4988235 AG

[♥ Lily ♥]

I like cows milk and goats milk. I also like goats cheese, plus it contains a lot more calcium than other types of cheese, so you don't need to eat much of it to get your daily calcium requirement.

(I learnt during nutrition classes in my secondary school that females need more calcium in their daily diet then men, but men require higher levels of protein in their daily diet than females.)