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body odor is genetic trait
east asians smell the best
because of this gene
The ABCC11 gene is known to determine axillary body odor and the type of earwax.[5][18][19][20] The loss of a functional ABCC11 gene is caused by a 538G>A single-nucleotide polymorphism, resulting in a loss of body odor in people who are specifically homozygous for it.[20][21] Firstly, it affects apocrine sweat glands by reducing secretion of odorous molecules and its precursors.[5] The lack of ABCC11 function results in a decrease of the odorant compounds 3M2H, HMHA, and 3M3SH via a strongly reduced secretion of the precursor amino-acid conjugates 3M2H–Gln, HMHA–Gln, and Cys–Gly–(S) 3M3SH; and a decrease of the odoriferous steroids androstenone and androstenol, possibly due to the reduced levels and secretion of DHEAS and DHEA (possibly bacterial substrates for odoriferous steroids).[5] Secondly, it is also associated with a strongly reduced/atrophic size of apocrine sweat glands and a decreased protein (such as ASOB2) concentration in axillary sweat.[5]
The non-functional ABCC11 allele is predominant among East Asians (80–95%), but very low in other ancestral groups (0–3%).[5] Most of the world's population have the gene that codes for the wet-type earwax and normal body odor; however, East Asians are genetically predisposed for the allele associated with the dry-type earwax and a reduction in body odor.[5][18][20] East Asians (Chinese, Koreans, and Japanese) have fewer apocrine sweat glands compared to people of other descent, making East Asians less prone to body odor.[22][23] The reduction in body odor and sweating may be due to adaptation to colder climates by their ancient Northeast Asian ancestors.[18]
Research has indicated a strong association between people with axillary osmidrosis and the ABCC11-genotypes GG or GA at the SNP site (rs17822931) in comparison to the genotype AA.[20]
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