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Thread: Is it possible to determine who of the two identical twin brothers is a father?

  1. #11
    Veteran Member Jehan's Avatar
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    It's possible that identical twins doesn't share the exact same adn but the difference is tiny. I doubt the parternity test who can be bought by the public would detect it. But the police acheive to do the difference.

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    Aging Tom Cat Apricity Funding Member
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    Quote Originally Posted by Seya View Post
    I don't see how possible...They have identical genes.
    my identical twin brother has 2 sons

    i take it genetically they are my sons too

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    No, they are identical
    All around me are familiar faces, worn out places, worn out faces
    Bright and early for the daily races, going nowhere, going nowhere

  4. #14
    der Knabenliebhaber Eugene Finkelstein's Avatar
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    From my quick read (only "abstracts" and "conclusions"), the summary:
    Yes, it can be done in most if not all, cases using the WGS technique. Although there are currently only a dozen of practically solved cases in paternity disputes and forensic investigations, they proved to be a success.
    Quote: ... arising from a single fertilization event, MZ twins nevertheless continue to acquire somatic mutations during their development, including those that occur in the germline. Provided that paternity had been narrowed down to the twin pair beforehand by classical DNA analysis, one post-zygotic mutation would suffice to assign the paternal compartment of an offspring genome unambiguously to either twin if that mutation is found in the offspring and one twin, but not in the other twin.
    Reading:
    1. Krawczak, M., Cooper, D. N., Fändrich, F., Engel, W., & Schmidtke, J. (2012). How to distinguish genetically between an alleged father and his monozygotic twin: a thought experiment. Forensic Science International: Genetics, 6(5), e129-e130.
    2. Weber-Lehmann, J., Schilling, E., Gradl, G., Richter, D. C., Wiehler, J., & Rolf, B. (2014). Finding the needle in the haystack: differentiating “identical” twins in paternity testing and forensics by ultra-deep next generation sequencing. Forensic Science International: Genetics, 9, 42-46.
    3. Krawczak, M., Budowle, B., Weber-Lehmann, J., & Rolf, B. (2018). Distinguishing genetically between the germlines of male monozygotic twins. PLoS Genetics, 14(12), e1007756.
    4. Yuan, L., Chen, X., Liu, Z., Liu, Q., Song, A., Bao, G., ... & Wu, Y. (2020). Identification of the perpetrator among identical twins using next-generation sequencing technology: A case report. Forensic Science International: Genetics, 44, 102167.
    5. Turrina, S., Bortoletto, E., Giannini, G., & De Leo, D. (2021). Monozygotic twins: Identical or distinguishable for science and law?. Medicine, Science and the Law, 61(1_suppl), 62-66.
    6. Rolf, B., & Krawczak, M. (2021). The germlines of male monozygotic (MZ) twins: Very similar, but not identical. Forensic Science International: Genetics, 50, 102408.
    7. Butler, J. M. (2023). Recent advances in forensic biology and forensic DNA typing: INTERPOL review 2019–2022. Forensic Science International: Synergy, 6, 100311

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    Only in extremely rare cases where mutations affect germ cells.

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    It is possible if you have good luck. Everyone has random mutations, also identical twins. Statistical analysis would find them, but you need perhaps a full genome scan. If you are male, then it is possible that only Y-chromosome is needed to scan, but it would be like a jackpot to get that mutation.

  7. #17
    der Knabenliebhaber Eugene Finkelstein's Avatar
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    One additional work, very new & summarizing in nature of all previous studies, also with some perspectives on future development of the issue:
    Hwa, H. L., Lin, C. Y., Yu, Y. J., Linacre, A., & Lee, J. C. I. (2024). DNA identification of monozygotic twins. Forensic Science International: Genetics, 69, 102998.

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