Psychopharmacology of Antidepressants and Antipsychotics

[Petros Agapetos]

Ropinirole is a D3 full agonist used for Parkinson's disease; It is a D2, D3 and D4 agonist, weak partial agonist on 5HT2A, which can be used to treat emotional and affective deficits seen with neuroleptic treatment on people diagnosed with psychotic disorders (particularly) - negative and cognitive symptoms. Also, an adjunct treatment for depression, anhedonia, lack of motivation,etc,.

Pramipexole (Cabergoline related compound) also a potent D3 agonist used to treat Parkinsonism. Can be used to treat anhedonia, orgasm dysfunction, sex drive in people treated with neuroleptics, by modulating dopaminergic neurotransmission. Both can be used in treatment resistant depression; or as an add-on to Abilify treatment (neuroleptic D2 partial agonist) for people diagnosed with psychotic illness and neuroleptic caused depression/anhedonia.

[Hadouken]

have you taken antidepressants petros ?

[Petros Agapetos]

have you taken antidepressants petros ?

Yes I am taking Welbutrin , which is a dopamine reuptake inhibitor, causes dopamine content in the synapses to increase; more dopaminergic transmission, more communication between different parts of the brain which use the neurotransmitter dopamine to communicate with one-another; But at the same time I am on Abilify; on such a dosage which covers 70%-90% dopamine D2 receptors, as well as D3 and D4 (unknown coverage). Abilify activates D2 receptors 30 % - 60% on the postynaptic (receiving nerve cell), which accomplished 1/3rd of the effect of dopamine on these receptors. And on presynatpic autoreceptors , Abilify activates them up to 75%, which means that the firing cells are only 25% activated - as a result - the action of the firing cell is blocked by 75%. So I end up having "modulated" dopaminergic state. Where dopamine levels are too high, they get lowered, where they are low, they get higher. But still, I have anhedonia, loss of libido, cognitive impairment / poor executive functions (ADHD worsening), etc.

[Hadouken]

Yes I am taking Welbutrin , which is a dopamine reuptake inhibitor, causes dopamine content in the synapses to increase; more dopaminergic transmission, more communication between different parts of the brain which use the neurotransmitter dopamine to communicate with one-another; But at the same time I am on Abilify; on such a dosage which covers 70%-90% dopamine D2 receptors, as well as D3 and D4 (unknown coverage). Abilify activates D2 receptors 30 % on the postynaptic (receiving nerve cell), which accomplished 1/3rd of the effect of dopamine on these receptors. And on presynatpic autoreceptors , Abilify activates them up to 75%, which means that the firing cells are only 25% activated (the action of the firing cell is blocked by 75%. So I end up having "modulated" dopaminergic state. Where dopamine levels are too high, they get lowered, where they are low, they get higher. But still, I have anhedonia, loss of libido, cognitive impairment / poor executive functions (ADHD worsening), etc.

what other antidepressants have you taken ?

[klarji]

what other antidepressants have you taken ?

Ho Hadouken are u still using antidepressants?
What da fa.k
You used them when I first saw you here 4 years ago
You have to be healthy now

[Hadouken]

Ho Hadouken are u still using antidepressants?
What da fa.k
You used them when I first saw you here 4 years ago
You have to be healthy now

I did big mistakes . 3 times I stopped taking them too abruptly by myself and have become even more ill

[Petros Agapetos]

what other antidepressants have you taken ?

Yes, I have taken Trintellix; It is an SSRI (selective serotonin reuptake inhibitor) and an almost full agonist on serotonin receptor 5HT1A which when activated causes dopamine release in certain parts of the brain - which causes treatment of depressive states of mind; 5HT1A is a major pharmacological target of all serotonin antidepressants. I like taking it; it elevated my mood; treated depressive thoughts and feelings ; while on Abilify which is also thought of as having antidepressant qualities (5HT1A partial agonist, partial agonist on D2, D3, and D4 receptors).

I have also tried escitalopram, the S-enantiomer of Citalopram; It is a decent SSRI; with a relatively mild side effects profile.

[Hadouken]

Petros do you know which antidepressants and which antipsychotics dont cause weight gain ?

[Petros Agapetos]

Petros do you know which antidepressants and which antipsychotics dont cause weight gain ?

Welbutrin and Venlafaxine are stimulating antidepressants they cause appetite suppression, so you'll lose weight on them.
Among antipsychotics; Abilify and Asenapine are probably the more weight-neutral than say Risperidone or Olanzapine.

[Hadouken]

Welbutrin and Venlafaxine are stimulating antidepressants they cause appetite suppression, so you'll lose weight on them.
Among antipsychotics; Abilify and Asenapine are probably the more weight-neutral than say Risperidone or Olanzapine.

I am taking venlafaxine but am still fat but I also take Perazine at night

I somehow think most of them make the metabolism slower and cause weight gain