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Using "EAST SICILY" as the reference since West Sicily is the outlier region of Trapani, while East Sicily is a better, more consistent sample for most Sicilians.
Closest is definitely various Aegean islands; Ikaria, Crete, Chios, Andros. The greatest genetic difference to Sicilians, seems to be in Macedonia.
Andros, Cyclades:
Chios, North Aegean:# Population (source) Distance
1 South_Italian 3.22
2 East_Sicilian 4.2
3 Central_Greek 4.41
4 Italian_Jewish 5.46
Chios and Samos, North Aegean:# Population (source) Distance
1 Central_Greek 3.39
2 South_Italian 4.06
3 East_Sicilian 4.34
4 Italian_Abruzzo 4.75
5 West_Sicilian 6.28
6 Ashkenazi 6.39
Crete and Amorgos (Cyclades):# Population (source) Distance
1 Central_Greek 3.87
2 East_Sicilian 4.63
3 Ashkenazi 5.31
4 Greek_Thessaly 6.11
5 Italian_Abruzzo 6.44
Tilos, Dodecanese:# Population (source) Distance
1 Central_Greek 3.36
2 East_Sicilian 4.66
3 South_Italian 5.24
4 Ashkenazi 5.57
5 Italian_Abruzzo 7.12
Andros, Cyclades:# Population (source) Distance
1 Central_Greek 3.84
2 East_Sicilian 4.69
3 South_Italian 5.2
4 Italian_Abruzzo 5.79
5 Ashkenazi 6.82
Crete:Population (source) Distance
1 South_Italian 3.68
2 Central_Greek 4.68
3 East_Sicilian 4.71
4 Italian_Jewish 6.91
5 Ashkenazi 6.99
Andros, Cyclades:# Population (source) Distance
1 Central_Greek 3.5
2 Italian_Abruzzo 4.64
3 East_Sicilian 4.75
4 South_Italian 5.39
5 West_Sicilian 6.27
6 Greek 6.37
Kalymnos, Dodecanese:# Population (source) Distance
1 Central_Greek 4.08
2 East_Sicilian 5.21
3 Italian_Abruzzo 5.57
4 Ashkenazi 6.48
5 South_Italian 6.92
Chios, North Aegean:# Population (source) Distance
1 South_Italian 4.14
2 Central_Greek 4.89
3 East_Sicilian 5.34
4 Ashkenazi 7.92
5 Italian_Abruzzo 8.26
Crete:# Population (source) Distance
1 South_Italian 4.4
2 Central_Greek 5.3
3 East_Sicilian 5.49
4 Ashkenazi 8
5 Italian_Jewish 8.05
Crete:# Population (source) Distance
1 Central_Greek 4.06
2 East_Sicilian 5.74
3 South_Italian 5.81
4 Ashkenazi 6.1
5 Italian_Abruzzo 7.38
Kythera:# Population (source) Distance
1 South_Italian 4.5
2 Central_Greek 4.86
3 East_Sicilian 5.78
4 Ashkenazi 8.28
5 Italian_Abruzzo 8.36
Crete:# Population (source) Distance
1 South_Italian 4.3
2 East_Sicilian 5.79
3 Central_Greek 6.06
4 Sephardic_Jewish 6.25
5 West_Sicilian 6.78
Kythera:# Population (source) Distance
1 South_Italian 5.12
2 Central_Greek 5.56
3 East_Sicilian 5.95
4 Ashkenazi 7
5 Sephardic_Jewish 7.6
Inousses/Ikaria/Chios (North Aegean) and Patmos (Dodecanese):# Population (source) Distance
1 Central_Greek 5.08
2 South_Italian 5.85
3 East_Sicilian 5.98
4 Ashkenazi 7.58
5 Italian_Abruzzo 8.39
6 Italian_Jewish 9.53
Crete:# Population (source) Distance
1 South_Italian 4.18
2 Central_Greek 4.91
3 East_Sicilian 6.06
4 Italian_Abruzzo 7.65
5 Ashkenazi 8.31
6 Sephardic_Jewish 8.76
Kalymnos, Dodecanese:# Population (source) Distance
1 Central_Greek 5.03
2 Ashkenazi 5.64
3 East_Sicilian 6.07
4 South_Italian 6.81
5 Greek 8
Ikaria, North Aegean:# Population (source) Distance
1 Central_Greek 4.99
2 East_Sicilian 6.35
3 South_Italian 6.35
4 Ashkenazi 7.03
5 Italian_Abruzzo 8.68
Chios, North Aegean:# Population (source) Distance
1 Ashkenazi 4.6
2 Central_Greek 5.62
3 East_Sicilian 6.39
4 Italian_Abruzzo 7.09
5 Greek 8.19
6 Greek_Thessaly 8.27
Laconia:# Population (source) Distance
1 Central_Greek 4.84
2 East_Sicilian 6.4
3 South_Italian 6.5
4 Italian_Abruzzo 7.1
5 Ashkenazi 7.68
6 Greek 9.25
Ikaria, North Aegean:# Population (source) Distance
1 Central_Greek 4.7
2 East_Sicilian 6.46
3 South_Italian 6.53
4 Greek 7.64
5 Greek_Thessaly 7.94
Chios, North Aegean:# Population (source) Distance
1 South_Italian 4.7
2 Sephardic_Jewish 6.53
3 East_Sicilian 6.58
4 Central_Greek 6.71
5 Italian_Jewish 7.77
6 Ashkenazi 8.5
7 Algerian_Jewish 8.69
Crete:# Population (source) Distance
1 South_Italian 4.04
2 Central_Greek 6.02
3 East_Sicilian 6.73
4 Italian_Jewish 8.48
5 Sephardic_Jewish 8.81
6 Italian_Abruzzo 8.9
Chios, North Aegean:# Population (source) Distance
1 Central_Greek 5.21
2 South_Italian 6.21
3 Greek 6.21
4 East_Sicilian 6.75
5 Italian_Abruzzo 7.93
6 Ashkenazi 8.55
Patmos, Dodecanese:# Population (source) Distance
1 South_Italian 5.86
2 Central_Greek 6.17
3 East_Sicilian 6.88
4 Italian_Abruzzo 8.38
5 Ashkenazi 9.36
6 Italian_Jewish 10.01
Messinia, Peloponnese:# Population (source) Distance
1 Central_Greek 5.56
2 East_Sicilian 6.99
3 South_Italian 7.3
4 Ashkenazi 7.7
5 Greek 7.74
Crete:# Population (source) Distance
1 Greek_Thessaly 2.6
2 Greek 6.08
3 Central_Greek 6.34
4 Ashkenazi 6.81
5 East_Sicilian 7.11
6 Italian_Abruzzo 7.96
7 West_Sicilian 9.31
Crete:# Population (source) Distance
1 Ashkenazi 6.45
2 Central_Greek 6.69
3 East_Sicilian 7.21
4 South_Italian 7.33
5 Sephardic_Jewish 8.98
Chios, North Aegean:# Population (source) Distance
1 Sephardic_Jewish 6.04
2 South_Italian 6.39
3 East_Sicilian 7.31
4 Italian_Jewish 7.43
5 Central_Greek 7.63
6 Ashkenazi 8.12
Crete:# Population (source) Distance
1 South_Italian 6.22
2 Central_Greek 7.02
3 East_Sicilian 7.31
4 Italian_Jewish 8.93
5 Ashkenazi 9.18
6 Sephardic_Jewish 9.89
Kalymnos, Dodecanese:# Population (source) Distance
1 Central_Greek 6.75
2 East_Sicilian 7.35
3 South_Italian 7.7
4 Ashkenazi 7.8
Laconia:# Population (source) Distance
1 South_Italian 5.41
2 Central_Greek 6.93
3 East_Sicilian 7.39
4 Sephardic_Jewish 7.72
5 Italian_Jewish 8.58
6 Italian_Abruzzo 8.96
Laconia:# Population (source) Distance
1 Greek_Thessaly 6.38
2 Central_Greek 6.67
3 Greek 6.8
4 Ashkenazi 7.39
5 East_Sicilian 7.45
6 Italian_Abruzzo 8.35
7 South_Italian 9.35
Euboea:# Population (source) Distance
1 Greek_Thessaly 5.48
2 Central_Greek 6.04
3 Italian_Abruzzo 6.04
4 Greek 6.81
5 East_Sicilian 7.53
6 Tuscan 8.82
7 Ashkenazi 9.05
Chios, North Aegean:# Population (source) Distance
1 Greek_Thessaly 3.16
2 Greek 5.25
3 Central_Greek 6.94
4 Italian_Abruzzo 7.26
5 East_Sicilian 7.57
6 Ashkenazi 7.85
7 Tuscan 8.22
Arcadia, Peloponnese:# Population (source) Distance
1 Central_Greek 6.22
2 South_Italian 7.09
3 East_Sicilian 7.73
4 Ashkenazi 8.25
5 Greek 9.65
6 Italian_Abruzzo 9.85
Chios, North Aegean:# Population (source) Distance
1 Greek_Thessaly 4.64
2 Central_Greek 7.01
3 Italian_Abruzzo 7.16
4 East_Sicilian 7.73
5 Ashkenazi 7.95
6 Greek 8.65
Crete:# Population (source) Distance
1 South_Italian 6.98
2 Central_Greek 7.51
3 East_Sicilian 7.81
4 Ashkenazi 8.64
5 Italian_Jewish 8.96
6 Sephardic_Jewish 9.72
7 Cyprian 10.69
Ikaria, North Aegean:# Population (source) Distance
1 South_Italian 6.52
2 Central_Greek 7.17
3 East_Sicilian 7.9
4 Sephardic_Jewish 8.83
5 Ashkenazi 8.91
Mani, Peloponnese:# Population (source) Distance
1 South_Italian 6.28
2 Central_Greek 7.41
3 East_Sicilian 7.9
4 Sephardic_Jewish 8.83
5 Italian_Jewish 9.93
6 Ashkenazi 10.03
Ikaria, North Aegean:# Population (source) Distance
1 Greek 4.61
2 Central_Greek 6.6
3 Ashkenazi 7.83
4 Greek_Thessaly 7.87
5 East_Sicilian 7.94
6 Italian_Abruzzo 8.31
Chios, North Aegean:# Population (source) Distance
1 South_Italian 5.22
2 Sephardic_Jewish 6.45
3 Italian_Jewish 6.87
4 Algerian_Jewish 7.6
5 Central_Greek 7.67
6 East_Sicilian 7.97
7 West_Sicilian 9.23
8 Italian_Abruzzo 9.49
Samos, North Aegean:# Population (source) Distance
1 Ashkenazi 5.68
2 Central_Greek 7.01
3 Greek 7.39
4 East_Sicilian 8.06
5 Greek_Thessaly 8.08
6 Italian_Abruzzo 8.94
Smyrna, Anatolia:# Population (source) Distance
1 Central_Greek 7.48
2 Italian_Abruzzo 7.6
3 West_Sicilian 7.78
4 South_Italian 8.11
5 East_Sicilian 8.11
6 Ashkenazi 8.51
7 Italian_Jewish 9.39
Messinia, Peloponnese:# Population (source) Distance
1 Italian_Jewish 6.56
2 South_Italian 6.92
3 Sephardic_Jewish 8.08
4 Central_Greek 8.26
5 East_Sicilian 8.3
6 Algerian_Jewish 8.46
7 Ashkenazi 9.16
8 Cyprian 9.42
Central Greece:# Population (source) Distance
1 Greek_Thessaly 4.87
2 Greek 6.69
3 Central_Greek 7.04
4 Italian_Abruzzo 8.01
5 East_Sicilian 8.34
6 Tuscan 9.04
7 Ashkenazi 9.67
Laconia, Peloponnese:# Population (source) Distance
1 Greek_Thessaly 4.76
2 Central_Greek 7.29
3 Ashkenazi 7.92
4 Greek 7.95
5 East_Sicilian 8.39
6 Italian_Abruzzo 9.36
7 South_Italian 10.09
8 West_Sicilian 10.55
Cyclades:# Population (source) Distance
1 Greek_Thessaly 6.37
2 Central_Greek 6.91
3 Greek 7.97
4 East_Sicilian 8.54
5 Ashkenazi 9.1
6 South_Italian 9.18
7 Italian_Abruzzo 9.94
Crete:# Population (source) Distance
1 South_Italian 7.35
2 Italian_Jewish 7.47
3 Central_Greek 8.26
4 Sephardic_Jewish 8.41
5 East_Sicilian 8.72
6 Algerian_Jewish 8.75
7 Ashkenazi 9.13
Mani, Peloponnese:# Population (source) Distance
1 South_Italian 7.63
2 Central_Greek 7.91
3 East_Sicilian 8.79
4 Italian_Jewish 9.09
5 Ashkenazi 9.31
Rhodes, Dodecanese:# Population (source) Distance
1 Greek_Thessaly 5.62
2 Central_Greek 7.66
3 Ashkenazi 8.02
4 Greek 8.33
5 East_Sicilian 8.79
6 Italian_Abruzzo 10.29
7 South_Italian 10.38
Chios, North Aegean:# Population (source) Distance
1 Central_Greek 8.34
2 South_Italian 8.46
3 East_Sicilian 8.84
4 Ashkenazi 9.29
5 Cyprian 10.73
6 Italian_Jewish 10.79
Samos and Euboea:# Population (source) Distance
1 South_Italian 8.08
2 Central_Greek 8.46
3 East_Sicilian 8.85
4 Ashkenazi 9.03
5 Cyprian 9.2
Laconia:# Population (source) Distance
1 Greek 4.76
2 West_Sicilian 6.13
3 Italian_Abruzzo 6.45
4 Tuscan 6.99
5 Central_Greek 8.23
6 Greek_Thessaly 8.4
7 East_Sicilian 8.86
8 Ashkenazi 9.84
Peloponnese:# Population (source) Distance
1 Greek_Thessaly 5.3
2 Greek 6.7
3 Central_Greek 7.54
4 Ashkenazi 7.62
5 East_Sicilian 8.99
6 Italian_Abruzzo 9.31
7 South_Italian 10.79
Macedonia:# Population (source) Distance
1 Italian_Abruzzo 6.42
2 Greek 6.54
3 Tuscan 8.3
4 Greek_Thessaly 8.35
5 West_Sicilian 8.42
6 Central_Greek 8.61
7 East_Sicilian 9
Kalymnos, Dodecanese:# Population (source) Distance
1 Greek_Thessaly 4.44
2 Greek 6.39
3 Ashkenazi 7.85
4 Central_Greek 8.02
5 East_Sicilian 9.22
6 Bulgarian 9.51
7 Italian_Abruzzo 9.79
Chios, North Aegean:# Population (source) Distance
1 South_Italian 7.44
2 Central_Greek 8.81
3 Sephardic_Jewish 8.95
4 Cyprian 9.05
5 Italian_Jewish 9.06
6 East_Sicilian 9.23
7 Ashkenazi 10.07
Macedonia:# Population (source) Distance
1 South_Italian 7.91
2 Central_Greek 8.51
3 Italian_Jewish 9.18
4 East_Sicilian 9.28
5 Ashkenazi 9.46
6 Cyprian 9.51
7 Sephardic_Jewish 9.74
Central Macedonia:# Population (source) Distance
1 Greek_Thessaly 4.73
2 Central_Greek 8.65
3 Italian_Abruzzo 8.92
4 Greek 9.21
5 Ashkenazi 9.37
6 East_Sicilian 9.48
7 Tuscan 9.57
8 West_Sicilian 10.76
9 South_Italian 11.59
Symi, Dodecanese:# Population (source) Distance
1 Greek 5.71
2 Greek_Thessaly 6.71
3 Bulgarian 7.13
4 Italian_Abruzzo 8.49
5 Tuscan 8.58
6 Romanian 9.32
7 Central_Greek 9.38
8 East_Sicilian 9.94
9 West_Sicilian 10.56
10 Ashkenazi 10.79
Central Greece:# Population (source) Distance
1 Sephardic_Jewish 6.23
2 South_Italian 7.41
3 Italian_Jewish 8.19
4 Algerian_Jewish 8.23
5 Tunisian_Jewish 8.96
6 Cyprian 9.9
7 East_Sicilian 10.05
8 Central_Greek 10.41
Kalymnos, Dodecanese:# Population (source) Distance
1 Greek_Thessaly 5.45
2 Tuscan 7.62
3 Greek 8.05
4 Italian_Abruzzo 8.16
5 Central_Greek 9.27
6 Bulgarian 9.36
7 East_Sicilian 10.08
8 Romanian 10.16
Epirus:# Population (source) Distance
1 South_Italian 8.88
2 Central_Greek 9.34
3 Cyprian 10.05
4 East_Sicilian 10.18
5 Italian_Jewish 10.32
Patras, Peloponnese:# Population (source) Distance
1 Greek 3.97
2 Greek_Thessaly 6.79
3 Central_Greek 8.95
4 Bulgarian 9.58
5 East_Sicilian 10.26
6 Italian_Abruzzo 10.53
7 Ashkenazi 11.12
8 West_Sicilian 11.26
Istanbul:# Population (source) Distance
1 Greek 4.14
2 Greek_Thessaly 5.83
3 Bulgarian 7.21
4 Central_Greek 8.77
5 Ashkenazi 9.82
6 Italian_Abruzzo 10.05
7 Romanian 10.05
8 East_Sicilian 10.3
9 West_Sicilian 11.99
10 Tuscan 12.26
Kastellorizo, Dodecanese:# Population (source) Distance
1 Greek 7.39
2 Central_Greek 8.63
3 Italian_Abruzzo 9.18
4 Greek_Thessaly 9.49
5 Ashkenazi 10.2
6 Bulgarian 10.37
7 East_Sicilian 10.38
8 South_Italian 11.91
Corinth, Peloponnese:# Population (source) Distance
1 South_Italian 8.56
2 Cyprian 9.71
3 Central_Greek 9.77
4 East_Sicilian 10.38
5 Italian_Jewish 10.56
6 Sephardic_Jewish 10.85
Kalymnos, Dodecanese:# Population (source) Distance
1 Greek_Thessaly 8.02
2 Central_Greek 9.33
3 Ashkenazi 9.64
4 East_Sicilian 10.38
5 Italian_Abruzzo 11.18
Thessaly:# Population (source) Distance
1 Cyprian 8.47
2 South_Italian 8.57
3 Central_Greek 9.77
4 East_Sicilian 10.53
5 Italian_Jewish 10.79
6 Sephardic_Jewish 10.99
Chios, North Aegean:# Population (source) Distance
1 Greek 5.41
2 Bulgarian 6.8
3 Greek_Thessaly 7
4 Tuscan 8.08
5 Italian_Abruzzo 8.27
6 Romanian 8.75
7 West_Sicilian 9.51
8 Central_Greek 9.88
9 East_Sicilian 10.54
10 Ashkenazi 10.7
Macedonia:# Population (source) Distance
1 Ashkenazi 9.67
2 Central_Greek 10.12
3 East_Sicilian 10.73
4 Greek 10.98
5 South_Italian 11.49
6 Italian_Abruzzo 12.07
Chios, North Aegean:# Population (source) Distance
1 Tuscan 7.33
2 Italian_Abruzzo 8.19
3 Greek 9.31
4 West_Sicilian 9.59
5 Central_Greek 10.74
6 East_Sicilian 10.78
Achaea, Peloponnese:# Population (source) Distance
1 South_Italian 9.82
2 Sephardic_Jewish 10.41
3 Central_Greek 10.88
4 East_Sicilian 11.36
5 Italian_Abruzzo 12.27
6 Cyprian 12.57
7 Italian_Jewish 12.69
West Macedonia:# Population (source) Distance
1 Greek 6.08
2 Central_Greek 10.62
3 Italian_Abruzzo 10.86
4 Bulgarian 11.23
5 Greek_Thessaly 11.69
6 West_Sicilian 11.75
7 East_Sicilian 11.81
Thessaloniki:# Population (source) Distance
1 Greek_Thessaly 5.41
2 Bulgarian 7.55
3 Greek 7.97
4 Romanian 8.37
5 Italian_Abruzzo 10.29
6 Central_Greek 10.48
7 Ashkenazi 11.14
8 Tuscan 11.28
9 Serbian 11.35
10 East_Sicilian 11.82
11 West_Sicilian 12.81
West Macedonia:# Population (source) Distance
1 Greek_Thessaly 5.94
2 Greek 7.05
3 Bulgarian 7.49
4 Romanian 8.89
5 Central_Greek 10.94
6 Italian_Abruzzo 11.11
7 Tuscan 11.19
8 Serbian 11.51
9 Ashkenazi 11.6
10 East_Sicilian 12.29
11 West_Sicilian 12.79
Macedonia:# Population (source) Distance
1 Greek_Thessaly 5.13
2 Bulgarian 9.08
3 Romanian 9.46
4 Greek 9.87
5 Tuscan 11.47
6 Serbian 11.84
7 Central_Greek 11.89
8 Italian_Abruzzo 12.05
9 Ashkenazi 12.16
10 East_Sicilian 12.78
11 West_Sicilian 13.89
# Population (source) Distance
1 Bulgarian 5.2
2 Romanian 6.36
3 Greek_Thessaly 8.98
4 Serbian 9.6
5 Greek 9.81
6 Moldavian 12.29
7 Ashkenazi 14.21
8 Central_Greek 14.57
9 Croatian 15
10 Italian_Abruzzo 15.1
11 Tuscan 15.57
12 East_Sicilian 15.82
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