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Ropinirole
Ropinirole is a D2, D3, and D4 dopamine receptor agonist. Its affinity for D3 receptors is 20 times greater than for D2 receptors [1]. Ropinirole is useful in treating SSRI-induced sexual dysfunction [2]. Ropinirole could be useful as an adjunctive treatment for treatment-resistant depression [3] Ropinirole is also useful in treating negative symptoms of schizophrenia [4]. Ropinirole is primarily used in the treatment of Parkinson's disease.
Pramipexole
Pramipexole is also primarily used in the treatment of Parkinson's disease. Pramipexole is also a D2-like receptor agonist: D2, D3, and D4, with the following intrinsic activities:
D2L [70%] = high partial agonist
D2S [130%] = superagonist
D3 [70%] = high partial agonist
D4 [42%] = partial agonist
Pramipexole has highest affinity for D3 receptors. Pramipexole is also useful as an adjunctive treatment for depression, anhedonia, and negative symptoms [4.1]
Cabergoline
Cabergoline is a D1, D2, D3, and D4 agonist. Cabergoline also has agonistic activity on 5HT1A and 5HT2A receptors. It is used to lower prolactin levels and treat SSRI-induced sexual dysfunction (low libido, anorgasmia). It can be used as an aphrodisiac, as it boosts libido, intensifies orgasms, and enhances sexual performance (shortens the refractory period after an orgasm), that is, with Cabergoline people can skip the post orgasm hangover [5].
Bromocriptine
Bromocriptine is a potent agonist at dopamine D2 receptors and various serotonin receptors. It also inhibits the release of glutamate. Bromocriptine is used to treat hyperprolactinaemia (high prolactin levels), neuroleptic malignant syndrome, and Parkinson's disease. Bromocriptine is also used to treat infertility, hypogonadism and diabetes II. Bromocriptine has also been found to reduce negative symptoms of schizophrenia [6].
Pharmacodynamics of Bromocriptine:
Dopamine D1 family
D1 (Ki=682 nM)
D5 (Ki=496 nM)
Dopamine D2 family
D2 (Ki=2.96 nM)
D3 (Ki=5.42 nM)
D4 (Ki=328 nM)
Serotonin 5-HT
5-HT1A (Ki=12.9 nM)
5-HT1B (Ki=355 nM)
5-HT1D (Ki=10.7 nM)
5-HT2A (Ki=107 nM)
5-HT2B (Ki=56.2 nM)
5-HT2C (Ki=741 nM)
5-HT6 (Ki=33 nM)
Note: Ki = dissociation constant. The smaller the Ki value the stronger the affinity (chemical binding strength).
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