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New Ancestry Software
It looks like there will be new ancestry software which is not based on Admixture program. Not sure how much it will be or if it will be free. https://eurasiandna.com/sapda-admixt...tes-revisions/
It seems to be more accurate with old DNA. They show a comparison of Altai Neanderthal using the new software and Gedmatch (Admixture)
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OVERVIEW
SAPDA SOFTWARE FEATURES & BENEFITS OVER CURRENTLY AVAILABLE CALCULATORS
- Use of multiple outgroup populations to increase certainty of mutations specific to various populations;
- Graphical evidence in support of admixture percentage calculations;
- Filtration of old mutations common to many populations in admixture calculations;
- Standard errors output to indicate confidence in admixture calculations;
- Single population sharing output (GSI) to more accurately quantify admixture percentages;
- Mitigation of ascertainment bias inherent in public SNP arrays.
DISCUSSION & EXAMPLES
MULTIPLE OUTGROUPS
Eurasians, whether Europeans or Asians, are genetically very similar to each other, with genetic similarities far outweighing any differences they have. Most Eurasians have descended from a few thousand individuals who roamed Eurasia during the Upper Paleolithic and thus share a huge amount of DNA. Thus an admixture inference program needs to determine which mutations are shared due to distant common origins and which ones due to more recent introgression.
It is for this reason that some bioinformatic software such as qpDstat, qp3pop, and qpAdm, which are included in the ADMIXTOOLS software suite available at Reich Lab, use outgroups to filter out older common ancestral alleles.
An extreme example of how ancestral alleles and SNP ascertainment bias distort admixture calculations using the program ADMIXTURE is Neanderthal. When the Neanderthal is processed with an ADMIXTURE based calculator, regardless of calculator design, the results show it to be around 90% African. Of course we know this inference is incorrect because the Neanderthal lineage diverged from humans over 500,000 years ago, with some hybridization with humans occurring around 50,000 years ago in Eurasia and NOT in Africa.
To illustrate this problem, a comparison is made of ADMIXTURE program based calculator results from Gedmatch.com with SAPDA calculator results for a higher coverage Altai Neanderthal genome with Gedmatch ID XV3025795.
It is expected that a calculator output show that Neanderthal is equally related to Eurasians and Africans, with a slight shift towards Eurasians, due to its limited admixture with Eurasians around 50,000 years ago, long after its split from the ancestral Neanderthal-Human lineage. However, we see this not to be the case.
Figure 1 shows that except for the SAPDA program, the ADMIXTURE program based various calculator projects erroneously indicate that the Neanderthal sample is around 90% African.
By contrast, SAPDA indicates greater shared drift between Eurasians and the Altai Neanderthal sample vs Altai Neanderthal and Africans, specifically, Siberians, American Indians, and East Asian Eurasians. This of course is a more expected result than the results using ADMIXTURE software, which tend to show the Altai Neanderthal sample as approximately 90% African.
It looks like the software will also show how your ancestry changed over time
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Fig 3 – Signature allele sharing between an Iraqi Kurd sample and various populations indicating a decline of West Eurasian admixture over time. This likely correlates with introgression of Central Asian admixture into Bronze Age herders and farmers of the Iranian plateau and Zagros mountains.
They give some examples of ranges for different populations
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The software also gives proof of ancestry
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Reply With Quote
Originally Posted by Matxe92
That's because he is an engineer (Dilawer Khan) and you are a designer. But I agree, that font is unreadable. It's not a company, it is his personal website.
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