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this is actually do to a process called recombination, by which we aren't exactly 25% each of our grandparents because we're only a random assortment of genes from both grandparents on one side or the other, so technically you can be 50% one grandparent and 0% the other although the odds are super super low
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I'll repeat myself and say that this is exceedingly unlikely to be a case of zero genetic inheritance from a great-grandparent. Such a thing has to be incredibly rare, if it's even possible. AncestryDNA just has a lousy ethnicity estimate, which we all kind of knew already.
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