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Thread: Which countries are taking the best measures against cononavirus?

  1. #41
    Veteran Member gixajo's Avatar
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    The easiest , cheapest and fastest measures to reduce the mortality rate of covid_19 is:

    Spoiler!


    And till now the only country that has miraculously get this is:

    Spoiler!


    Who has the better means to

    Spoiler!


    because it is a

    Spoiler!


    But of course,my opinion is biased, is simply envy seeing the alleged number of deads in my country, so don´t take me into account.



    It´s only one of the possible hypothesis.
    "Amicus Plato, sed magis amica veritas"

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    Quote Originally Posted by War Chief View Post
    East Asians are just on a whole other level of smart and organized. Even put central Europeans to shame.
    Proud to be predominant above European


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    Senior Member Kawaiine's Avatar
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    North Korea does the best of preventing against the Coronavirus pandemic


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    Quote Originally Posted by Kawaiine View Post
    Proud to be predominant above European
    But you guys lack in many areas. Physically weaker etc.

  5. #45
    Senior Member Kawaiine's Avatar
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    Quote Originally Posted by War Chief View Post
    But you guys lack in many areas. Physically weaker etc.
    Everyone has their own strengths and weaknesses, you can’t compare west to east, as we are completely different in many aspects


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    I think China defeated the Coronavirus so I think China.
    “To live is the rarest thing in the world. Most people exist, that is all.” ― Oscar Wilde “It is better to be hated for what you are than to be loved for what you are not.” ― Andre Gide, Autumn Leaves
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    latvia,slovakia,belarus, new zealand(1 dead) ,uruguay,Kazakhstan,Sri Lanka,(0 deaths),South Africa (2 deaths),Estonia,Bangladesh,Armenia,Hong Kong,russia,germany,Bulgaria(8 D)Ukraine(10 D)Hungary(13 D)Taïwan are the best for managing that at their best,i don't agree with the totalitarism of south korea and singapor but they did it well too for "democratic" countries,i think than Trump maybe a bit on the late is in the truth too,"the cure shouldn't worse than disease",the country who have closed there borders very soon and than testing very soon are the ones who are managing that better even with losts for sure but they have limit the damages at the minimum ,read the the stats,ok there is a lot of smalll islands for sure,i think we could tell than until under 10 dead it's very good as managment ,the true catastroph is in italy and spain,shit,at them both is more than 17.000 deaths,but chineses have lied on their numbers,they have fucked up, completly even my country,France, do it a bit better
    my opinion :as the level goes a bit up and the mode of transmition seems more contagious than a normal flu,and than after than an 14yo portuguese boy is dead from this flu just some few days after an 16yo french girl ,we should be very carefull and social distance is an absolute necessity without being paranoïd but conscious,but the containment is unnecessary to my eyes because if you want to live in pyongyang-dead-town it's your choose ,we had an ex-minister died at 75 in france of the COVID ,but even it's sad i still don't consider that an epidemic at the human scale,should we?
    the cluster where starting the spreading in the east of france is from an evangelic gathering,and as good christians they share(dark humour),in my department there is 48 active cases and 1 dead

    The virus causing the epidemic of COVID-19, the SARS-CoV-2 would have already mutated and its mutation would have produced a more virulent strain, the more 'aggressive' and potentially more deadly ?

    It is alleged on march 3rd a chinese team, in a study published in National Science Review. After having analyzed 103 complete genomes collected from patients chinese, australian and Korean researchers led to the following conclusion : there would be two virus strains distinct from the SARS-CoV-2, a strain L and a strain S, strain L having mutated from the strain S and that would be more 'aggressive' since it would be responsible for 70% of reported cases, against 30% for the type-S.

    pandemonium and loud screams, the new just released has made the tour of the world that once more, and as we will see, it has been very seriously questioned, and by the authors of the study themselves.
    What is an RNA virus ?

    Let's go back to the virus itself and to its nature : the SARS-CoV-2 is an RNA virus. It has 29 903 bases containing 15 genes. RNA viruses, this means that to replicate itself, it enters into a cell, copy it with its own tools, its RNA and recreates virions by hundreds of thousands of copies, which will then be released again in the body, and so on.

    What is important to know is that RNA viruses mutate much more easily, and more quickly, than the DNA viruses. Why ? Because each replication, the nucleic acids are poorly copied, I remind you that the four bases of RNA are A G C U (the U replaces the T in DNA). By making hundreds of thousands of copies, statistically, there are very often mistakes : a letter jumps is replaced by another. According to Anne Goffard, virologist, researcher and doctor at the university hospital of Lille that we have queried, the virus mutates and 100,000 to a million times in the viral life cycle, approximately every six hours.

    It should be noted that these errors are common in the replication of genetic, are for the most part corrected in the case of DNA, by mechanical repair which ensure a better stability of the genome. However, RNA viruses do not have a priori this type of tool, or tools that are much less effective that those of our cells... hence the higher rates of mutations.

    Furthermore, these mutations in the viral most often have little consequences, or negative consequences that make the most of the time the virus inoperative, given its low number of genes. It suffices that a be amended to ensure that all mechanical viral grinds to a halt.
    The consequences of the changes

    But quite often, these mutations are said to be ' silent ', first of all, because the basics are taken by 3 to be translated into amino acids, so when one of the bases changes, two possibilities occur : either it does not change the amino acid because several combinations of bases can produce the same molecule, or it changes an amino acid, but this will not, however, result in a change of the function of the protein (the protein surface, for example, the Spike protein has around 1300 amino acids), it can most of the time continue to fulfill its role even with a different amino acid.

    So you can understand that all of these changes, as many are, they are successful only very rarely to a change in phenotype and function viral. Today, it is estimated that the genome of the virus is still similar to the one appeared in Wuhan to 99,9999%.

    Let's go back therefore to this study, and these two strains of L and S. To begin, the researchers themselves have recognized that the data were 'very limited' (103 genomes, as I mentioned) and that there should be further work to confirm or disprove their analysis. Many researchers were highly critical, going so far to request withdrawal of the publication because not only of sample too low, but also of misinterpretation of the data statistics, and above all, the fact that they are not based on any clinical data.

    What do we know today of the course phylogeny of SARS-CoV-2 ?

    The researchers believe that the virus has changed little and that all of these changes cyclical, only 2 on average would be selected each month and would affect a portion of the genome large enough to be at the origin of new strains – we should rather speak of isolates, but without that it does not change anything to its virulence (the term'aggressiveness' is very widely anthropomorphic), or to its contagiousness.

    We may as well retrace the route of the virus from its origins in Wuhan, and how these different mutations to be harmless have infected different clusters, what are researchers doing real-time on the site Next Strain.

    In the case where these mutations are not silent, the two main possibilities are either the increase of the infectiousness, which is a reduction of the virulence – unless the virus is deadly, the more it can spread, the more it is perennial and therefore natural selection will most of the time in the sense of a mitigation, rather than in the sense of an increase of the lethality.

    How much of an influence on the development of a vaccine ?

    Another crucial question arises about the mutations of the virus, it is the one of the single vaccine. The rate of structural change of the influenza virus is such that it requires to produce a new vaccine each year for example. What will happen to the SARS-CoV-2 ? Everything will depend on the mutation rate of the surface antigen, the protein Spike.

    If the mutations perennial often affect this protein, then the single vaccine will not be effective, but the SARS-CoV-2 can also, losing some of its virulence, and eventually behave like its other cousins coronavirus, those who are responsible for our colds seasonal (OC43 or 229E) becoming totally trivial and eventually no longer require the vaccine.

    A SARS-CoV-2 is stable enough to not require a single universal vaccine ? A little less stable to resemble the flu and may require an annual vaccine ? Or totally benign to end up looking like a cold ? Once again, to be able to slice it, it'll have to wait until further work – and in particular those of Anne Goffard, who has filed a request for funding to sequence the isolates circulating in France, and try to retrace precisely the evolution of the virus since its appearance in China in the month of December last year until today.


    https://www.worldometers.info/coronavirus/
    Country,
    Other
    Highlighted in green
    = all cases have recovered from the infection

    Highlighted in grey
    = all cases have had an outcome (there are no active cases)

    The "New" columns for China display the previous day changes (as China reports after the day is over). For all other countries, the "New" columns display the changes for the current day while still in progress.
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