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To understand why Davidski does those types of things you have to go back to 2012 which is a time period probably no one here is familiar with. That’s when he became enemies with the Greek scientist Dienekes Pontikos. If it wasn’t for Pontikos Gedmatch would probably not exist because Dienekes is the guy that produced the DIY Dodecad software which allows calculators to function on Gedmatch.
Needless to say Dienekes was much more skilled with DNA tools than Davidski who was a true amateur and was very lacking on understanding on how these things worked.
You can see some of their arguments from 2012 on Dienekes blog at http://dodecad.blogspot.com/2012/08/...ffect.html?m=1
For example Davidski was foolishly arguing that he understood the calculator effect to which he was truly clueless
Polako also proposes a "solution" to the problem:
I actually designed my Eurogenes ancestry tests for Gedmatch with this problem in mind, by only using academic references to source the allele frequencies. This means that test results for Eurogenes project members and non-members are directly comparable. Perhaps other genome bloggers can eventually do the same?
The only effect of this "solution" is to ensure that there is a "calculator effect" for everyone using his tools. For example, if he uses only published Finns and Lithuanians to build his calculator, then every Finn and Lithuanian who takes his test will wonder why he is "different" from the published Finns and Lithuanians, because they will all suffer a "calculator effect" with respect to the reference populations. So, perhaps they will all be on equal footing with respect to each other, but their results will all be biased because of the issue I had identified.
Moreover, their results will never improve as more people join his Project, because these new people will not be included in newer versions of calculators: all users of DIY Eurogenes tools will continue to receive sub-par results. Well, small consolation, at least they'll all receive comparable sub-par results
12 comments:
AnonymousAugust 11, 2012 at 2:30 PM
I try to ignore Polako as much as possible. It's apparent to everyone with a modicum of critical talent that Eurogenes exists purely to assuage his own ethnic insecurities and at the same time find 'undesirable' admixture in populations he dislikes (basically Southern and Western Europeans). He's not a scientist. He wears his agenda on his sleeve. Polako's thought process can be summarised as thus: If it finds less non-European admixture in Poles, it's correct. If it finds more admixture in Poles, it requires revision.
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DienekesAugust 11, 2012 at 2:46 PM
I try to ignore Polako as much as possible.
That is probably best, but I wanted to prevent other genome bloggers from making the same mistake of thinking that by removing project samples they're actually creating better calculators.
Reply
DavidskiAugust 11, 2012 at 3:13 PM
You're missing the point, as usual.
There are lots of people out there confused RIGHT NOW by the results your tools are producing. They have a right to be confused, because the results are useless.
It doesn't help them that maybe in 5 years you'll have enough samples to eliminate the Calculator Effect from many of your tests.
Have some consideration for other people, and stop thinking about yourself and your blog for once.
Explain clearly why people who aren't part of your project can't rely on your population portraits and oracle results.
Reply
DienekesAugust 11, 2012 at 4:08 PM
You're missing the point, as usual.
There are lots of people out there confused RIGHT NOW by the results your tools are producing. They have a right to be confused, because the results are useless.
It is you who is missing the point.
If there is a "calculator effect", then it affects ALL people who use your tools, because NONE of them have been included in the admixture analysis that produced them. By your own admission, you use only "academic references".
Your "fix" to the problem is to make everyone suffer a bias, including your own project members. The fact that all people (project members or not) who use your tools are on equal footing is no consolation, because they are ALL getting bad results.
In the case of the Dodecad Project, the results obtained by project members are as good as can be hoped for, while the results obtained by non-members using DIY tools may suffer a small bias, which will continue to decrease over time. Moreover, whatever bias exists for the Dodecad Project is reduced compared to an "academic only" approach, because the components are inferred with a larger and more repsentative collection of samples.
There is no magic bullet to obtaining higher accuracy.
Dodecad = Great results for some + slightly biased results for non-participants
Eurogenes = Biased results for everyone, participant and non-participant alike.
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