Correlationship between human macrohaplogroups and viral infections

[Shubotai]

First of all, there has been no research that connects human haplogroups to coronavirus infections and definitely not any large scale research to discern the relationship between human haplogroups and viral infections. However, there is some knowledge about how some viruses like HIV are mainly distributed in sub-saharan Africa.

Viruses are distant cousins of the other five life forms that are found on Earth. Animals, plants, fungi, bacteria and protozoa are all cellular organisms based on DNA while viruses are non-cellular organisms based on RNA and include a smaller but ancestral minority which is based on DNA. All of the major viruses are round shaped organisms based on RNA. In RNA the base thymine (T) has been substituted by the base uracil (U) resulting in the viral genome consisting of A, G, C, U while the cellular genomes consist of A, G, C, T.

The general idea that I am going to conceive here is that there is a general correlation between the family of COV coronaviruses and y-dna haplogroup F descendants and a correlation between HTLV retroviruses and y-dna haplogroup DE. Similarly, there seems to be a general correlation between the family of COV coronaviruses and mtdna haplogroup N descendants and a correlation between HTLV retroviruses and mtdna haplogroup M descendants. In the case of African mtdna haplogroups the picture is definitely more complex but I would suggest that mtdna haplogroups that spread with Bantu or Afroasiatic expansions namely L3b'f, L3c'd, L3'i'k'x and possibly L3h are more likely to correlate with the HTLV family, while I would express uncertainty about L3h, L3a and possible correlation thereof with COV family and total uncertainty about older mtdna haplogroups L4, L6, L2, L5, L1 and L0.

The ATL retrovirus, a member of HTLV family is mainly distributed in isolated regions of Japan, Tibetans and sub-saharan Africans. So while Japanese and Tibetans experienced few and none COV exposure respectively, they have had to deal with the ATL retrovirus. Previously, Japanese and Tibetan populations also experienced few or none exposure to SARS. We would also expect similar behaviour from D-M15, a haplogroup that more commonly occurs in south Chinese populations. Neighbouring regions also like Mongolia and Korea have experienced
a low number of coronaviruses cases supposedly because of the prevalence of mtdna M.

It is noteworthy that the previous SARS virus had way more limited distribution but higher mortality culminating in 17% of the patients in South Korea, Taiwan, Hong Kong and Singapore. The majority of the patients likely belonged to haplogroup O.

It is also possible that these ancient Asian populations have developed some kind of immunity to the coronavirus diseases.

Haplogroup NO carriers descend from later populations coming from macrohaplogroup F and since generally haplogroups do show correlation with various diseases it is more likely that they would also be exposed to COV but not to HTLV.

HIV is a virus mainly distributed in sub-saharan Africa and it has a common origin with HTLV viruses and it also affects same parts in the human organism. Therefore I suggest that it also has correlation with the YAP+ haplogroup.

The case of y-dna C is more tricky. It doesn't share many mutations with haplogroup F and the populations that descend from it diverged a long time ago so it could very well be that is has also acquired some kind of immunity to coronavirus, but there should be caution in any case. From the existing evidence, it seems that Mongolians have one of the lowest exposure to coronavirus.

In Europe, Lombardy in Italy was the first region that reported a high number of coronavirus cases and over an extended period of time. Lombardy is also a region with one of the highest frequencies of haplogroup R1b. There was also a research conducted on this region that is referenced below that reached the same conclusion.

African Americans is an other group where many coronavirus cases were reported. This more likely happened because of worsen healthy conditions and poor access to medical treatment but the haplogroup distribution is also of interest. African Americans carry roughly 60% haplogroup E and 40% haplogroup R1b and a wide range of mtdna L, especially L3. It is unknown whether the positive persons belonged to one or the other type but there could likely be a higher number of R1b patients.

A Chinese research on correlation between blood types and coronavirus exposure examined the city of Wuhan for blood-type distribution and found 32.16%, 24.90%, 9.10% and 33.84% for A, B, AB and O, respectively. The 1,775 patients with COVID-19 from Wuhan Jinyintan Hospital showed an ABO distribution of 37.75%, 26.42%, 10.03% and 25.80% for A, B, AB and O, respectively. The proportions of blood groups A, B, AB and O in the 206 dead patients were 41.26%, 24.27%, 9.22% and 25.24%, respectively. The results revealed a higher risk associated with blood-type A and coronavirus exposure and a lower risk for blood type O.

Later, a similar Russian research found a higher risk associated with blood-type B and coronavirus exposure and a lower risk for blood type O. In Europe there is a high frequency of blood type A, and an elevated frequency of blood type B in east Europe, while the highest frequncy is still attained by blood type O. There is a high frequency of blood type A in Turkey and a high frequency of blood type B in the Indian subcontinent. There is a high frequency of blood type O in Native Americans. Worldwide blood type O is the most common, followed by A, B and AB. Essentially, the presence of either A or B protein in the blood is associated with a higher risk of coronavirus while the absence of these proteins which is named blood type O is associated with a lower risk of coronavirus. However, this is a correlation and does not mean that proteins A and B necessarily assist coronavirus spread.

If a person is prone to a coronavirus disease or an atl disease it is highly unlikely that the person will ever be prone to the other type of disease.

Isolated or insular populations may be more susceptible to various types of diseases and more rarely, resistant to some.

Finally, based on the basic premise that correlation does not mean causation, these evidence should not be taken as granted and when dealing with diseases or even physical abilities autosomal dna plays a much more important role than haplogroup correlations and blood types and there should be many genes that should be studied for their distribution in the general population and calculating the total outcome of their effect, that would lean towards or away from a certain type of disease or physical ability.

DE HTLV Retrovirus
F COV Coronavirus
C COV Coronavirus?

M HTLV Retrovirus
N COV Coronavirus
L HTLV Retrovirus OR COV Coronavirus

1. Uracil within DNA: an actor of antiviral immunity
2. Relationship between the ABO Blood Group and the COVID-19 Susceptibility
3. The potential influence of human Y-chromosome haplogroup on COVID-19 prevalence and mortality
4. Distribution of Two Subgroups of Human T-Lymphotropic Virus Type 1 (HTLV-1) in Endemic Japan