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Thread: W Asians don't score much E Asian using calculators

  1. #11
    Veteran Member Zoro's Avatar
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  2. #12
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    Quote Originally Posted by Zoro View Post
    Here is additional PROOF about how calculators should not be relied on for total E Asian admixture.

    These are F2 genetic distances (Admixtools 2) from a high quality WGS 7000 year old E. Asian called Devils-Gate-N. Whole genomes of various Asians and Europeans were used for comparison to maximize overlapping SNPs to 200,000 with no missing SNPs in any of the populations.

    You can easily see that these results agree with the qpAdm results for Kurds where Kurds have lower genetic distance to Devils-Gate-N than other W. Asians such as Kayseri Turks, Armenians, Georgians, Hasanlu-IA, Arabs.

    I realize that some other Turks would be closer and I would be glad to include them if there are WGS of them so for now I only have Kayseri Turks (2 samples). I also didn't have access to other Iranian WGS samples except for the 2 Fars ones

    Keep in mind if a population has S. Eurasian ancestry it would also be higher in the list because there's quite a bit of shared ancestry between S. Eurasian (Onge like) and E. Eurasian

    Sorted from closest genetic distance to ancient E. Asian to furthest based on F2 and Z score. W. Asians are highlighted


    NO. POP1 POP2 F2 SE Z
    1 Devils-Gate-N-WGS Eskimo-Chaplin 0.222 0.001 247
    2 Devils-Gate-N-WGS Kolyma-Mesol-WGS 0.224 0.001 155
    3 Devils-Gate-N-WGS Eskimo-Sireniki 0.224 0.001 276
    4 Devils-Gate-N-WGS China-Tianyuan-UP 0.24 0.002 143
    5 Devils-Gate-N-WGS Turkmen 0.241 0.001 222
    6 Devils-Gate-N-WGS Bashkir 0.244 0.001 262
    7 Devils-Gate-N-WGS Saami 0.247 0.001 288
    8 Devils-Gate-N-WGS Yana-UP-WGS 0.249 0.001 189
    9 Devils-Gate-N-WGS Tatar-Volga 0.249 0.001 228
    10 Devils-Gate-N-WGS Punjabi 0.251 0.001 280
    11 Devils-Gate-N-WGS Kurds-IRAQ 0.253 0.001 267
    12 Devils-Gate-N-WGS Pathan 0.253 0.001 273
    13 Devils-Gate-N-WGS Kalash 0.254 0.001 356
    14 Devils-Gate-N-WGS UstIshim-UP 0.255 0.002 170
    15 Devils-Gate-N-WGS Brahui 0.255 0.001 307
    16 Devils-Gate-N-WGS MA1-ANE 0.256 0.002 152
    17 Devils-Gate-N-WGS Karelia-EHG 0.256 0.001 183
    18 Devils-Gate-N-WGS Balochi 0.256 0.001 270
    19 Devils-Gate-N-WGS Turkish-KAYSERI 0.256 0.001 325
    20 Devils-Gate-N-WGS Kotias-CHG 0.257 0.001 240
    21 Devils-Gate-N-WGS Estonian 0.257 0.001 299
    22 Devils-Gate-N-WGS Iranians-FARS 0.258 0.002 172
    23 Devils-Gate-N-WGS Georgian 0.258 0.001 263
    24 Devils-Gate-N-WGS Sardinian 0.258 0.001 305
    25 Devils-Gate-N-WGS Armenian 0.259 0.001 260
    26 Devils-Gate-N-WGS Bulgarian 0.259 0.001 316
    27 Devils-Gate-N-WGS Iran-Hasanlu-IA 0.26 0.001 218
    28 Devils-Gate-N-WGS Villabruna-WHG 0.261 0.001 207
    29 Devils-Gate-N-WGS Jordanian 0.261 0.001 271
    30 Devils-Gate-N-WGS Saharawi 0.268 0.001 258
    31 Devils-Gate-N-WGS Khomani-San 0.306 0.001 213
    Before someone asks the F2 genetic distances posted above are much more accurate than for example distances based on PCA coordinates of G25 or distances based on Gedmatch calculators for the reason that these are based on direct one-to-one SNP comparisons between ancient E. Asian and the various pops in the list.
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    Quote Originally Posted by Dr_Maul View Post
    Target: Kurdish
    Distance: 1.8512% / 0.01851186
    32.8 Kura-Araxes_ARM_Kaps
    24.4 IRN_Ganj_Dareh_N
    17.2 Levant_PPNB
    13.0 Yamnaya_RUS_Samara
    11.6 TUR_Barcin_N
    1.0 Han

    Target: Kurdish
    Distance: 2.4473% / 0.02447277
    32.6 IRN_Ganj_Dareh_N
    22.2 TUR_Barcin_N
    19.0 Levant_PPNB
    14.0 Yamnaya_RUS_Samara
    12.0 GEO_CHG
    0.2 Han

    Code:
    TUR_Barcin_N,0.1175998,0.180118,0.0035312,-0.101158,0.0510443,-0.0483875,-0.0043582,-0.0069334,0.0362287,0.0807473,0.0079718,0.0118803,-0.0234545,0.0004691,-0.0419807,-0.0101913,0.0233091,0.0019866,0.0136954,-0.0097489,-0.0142249,0.0057723,-0.0041232,-0.0031658,-0.0043437
    Han,0.0206952,-0.4507105,-0.0082967,-0.0651579,0.0780846,0.0374475,0.0029055,-0.004804,-0.0150232,-0.0031146,-0.0495875,-0.0070573,0.0072707,-0.0081072,-0.0043305,0.0012535,0.0017542,-0.0008638,-0.0020455,-0.0102206,0.0122397,0.0069582,0.0141063,-0.0012925,-0.0022315
    IRN_Ganj_Dareh_N,0.0430252,0.0664158,-0.1550722,0.0047158,-0.122669,0.0235384,0.017109,-0.0011998,-0.082546,-0.0544158,-0.0028258,-0.0016186,0.0044896,-0.0062756,0.0316498,0.0561384,-0.0054242,0.0068664,0.0136508,-0.0334162,0.00856,-0.028836,-0.0110678,-0.039331,0.0222254
    Kura-Araxes_ARM_Kaps,0.1013025,0.133034,-0.07071,-0.043605,-0.0498555,-0.0092035,0.008108,-0.011653,-0.066368,-0.01631,0.0030855,0.011015,-0.019846,0.005849,0.0042075,-0.0102095,-0.0001305,-0.003927,-0.001697,0.0032515,0.003494,-0.000247,-0.0036975,-0.0090975,-0.0030535
    Levant_PPNB,0.072847,0.1639064,-0.0316026,-0.1361132,0.0332986,-0.0645352,-0.0134426,-0.0147684,0.0741604,0.03601,0.0188046,-0.0150764,0.035738,0.0025596,-0.0217696,0.006099,0.0098048,-0.0013176,-0.0047264,0.0188088,-0.001797,0.0071472,0.0008872,-0.0056874,-0.0037602
    Yamnaya_RUS_Samara,0.1255849,0.089028,0.0426986,0.1153479,-0.0287232,0.0450564,0.0036033,-0.0025642,-0.0559032,-0.0728943,0.0018222,3.32e-05,-0.0026924,-0.0233041,0.0366141,0.0157633,-0.0012316,-0.0017879,-0.0038408,0.0137704,-0.0031749,0.0007557,0.0110649,0.0186102,-0.004537
    (I replaced the Kura Axes with CHG on the other one)
    With Devil's Gate Cave instead of Han

    Target: Kurdish
    Distance: 1.8563% / 0.01856289
    32.8 Kura-Araxes_ARM_Kaps
    24.4 IRN_Ganj_Dareh_N
    17.4 Levant_PPNB
    13.0 Yamnaya_RUS_Samara
    11.4 TUR_Barcin_N
    1.0 RUS_Devils_Gate_Cave_N

    Target: Zaza_Dersim
    Distance: 1.9318% / 0.01931776
    31.4 Kura-Araxes_ARM_Kaps
    20.4 IRN_Ganj_Dareh_N
    16.8 Yamnaya_RUS_Samara
    15.2 TUR_Barcin_N
    14.6 Levant_PPNB
    1.6 RUS_Devils_Gate_Cave_N

    Target: Iranian_Lor
    Distance: 1.7713% / 0.01771342
    29.2 IRN_Ganj_Dareh_N
    28.8 Kura-Araxes_ARM_Kaps
    18.4 Levant_PPNB
    11.2 Yamnaya_RUS_Samara
    10.4 TUR_Barcin_N
    2.0 RUS_Devils_Gate_Cave_N

    Target: Talysh_Azerbaijan
    Distance: 1.6439% / 0.01643888
    41.6 Kura-Araxes_ARM_Kaps
    20.4 IRN_Ganj_Dareh_N
    13.6 Levant_PPNB
    12.0 Yamnaya_RUS_Samara
    9.6 TUR_Barcin_N
    2.8 RUS_Devils_Gate_Cave_N

    Target: Azeri
    Distance: 1.7081% / 0.01708131
    39.0 Kura-Araxes_ARM_Kaps
    17.0 Levant_PPNB
    16.0 IRN_Ganj_Dareh_N
    12.8 Yamnaya_RUS_Samara
    9.0 TUR_Barcin_N
    6.2 RUS_Devils_Gate_Cave_N

  4. #14
    Veteran Member Zoro's Avatar
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    I'm also posting this based on modern Eskimos because there are sometimes some damage in ancient DNA. So this should be regarded a little more accurate than the one based on Devils-Gate because the quality of modern sequences is better than ancients

    NO. POP1 POP2 F2 SE Z
    1 Eskimo-Sireniki Eskimo-Chaplin 0.21 0.0011 184
    2 Eskimo-Sireniki Devils-Gate-N-WGS 0.224 0.0008 276
    3 Eskimo-Sireniki Kolyma-Mesol-WGS 0.227 0.0012 197
    4 Eskimo-Sireniki Turkmen 0.249 0.0010 239
    5 Eskimo-Sireniki Bashkir 0.249 0.0010 259
    6 Eskimo-Sireniki MA1-ANE 0.251 0.0015 163
    7 Eskimo-Sireniki China-Tianyuan-UP 0.251 0.0014 182
    8 Eskimo-Sireniki Saami 0.251 0.0008 314
    9 Eskimo-Sireniki Yana-UP-WGS 0.253 0.0011 241
    10 Eskimo-Sireniki Karelia-EHG 0.253 0.0007 380
    11 Eskimo-Sireniki Tatar-Volga 0.255 0.0011 242
    12 Eskimo-Sireniki Punjabi 0.256 0.0010 265
    13 Eskimo-Sireniki Pathan 0.257 0.0009 302
    14 Eskimo-Sireniki Kalash 0.257 0.0007 351
    15 Eskimo-Sireniki Kurds-IRAQ 0.258 0.0011 233
    16 Eskimo-Sireniki Brahui 0.259 0.0010 259
    17 Eskimo-Sireniki Estonian 0.259 0.0008 318
    18 Eskimo-Sireniki Balochi 0.259 0.0008 329
    19 Eskimo-Sireniki Turkish-KAYSERI 0.26 0.0009 297
    20 Eskimo-Sireniki UstIshim-UP 0.261 0.0012 220
    21 Eskimo-Sireniki Iranians-FARS 0.261 0.0011 231
    22 Eskimo-Sireniki Bulgarian 0.261 0.0008 324
    23 Eskimo-Sireniki Kotias-CHG 0.262 0.0012 220
    24 Eskimo-Sireniki Armenian 0.262 0.0011 244
    25 Eskimo-Sireniki Georgian 0.262 0.0009 287
    26 Eskimo-Sireniki Sardinian 0.263 0.0008 335
    27 Eskimo-Sireniki Iran-Hasanlu-IA 0.264 0.0010 253
    28 Eskimo-Sireniki Jordanian 0.265 0.0009 303
    29 Eskimo-Sireniki Villabruna-UP-WHG 0.266 0.0014 190
    30 Eskimo-Sireniki Saharawi 0.274 0.0009 294
    31 Eskimo-Sireniki Khomani-San 0.313 0.0013 240

  5. #15
    Veteran Member Zoro's Avatar
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    Quote Originally Posted by Leto View Post
    With Devil's Gate Cave instead of Han
    This is precisely why I'm posting direct gene-to-gene one-to-one comparisons between E. Asians and W. Asians because those calculator results have a million things that can skew results.

    So when in doubt always do a gene-to-gene count of the number of similar genes between E. Asians and W. Asians. It's simple and you don't have to worry about any other factors that can skew results.

    My moto is keep it simple and do a manual one to one comparison of every SNP.


    What you posted shows Kurds with highest Iran-N. Iran-N is a bit of a mystery. Some of Harvard’s models show it with 22% AG3 related and other Harvard models show it with 8% Onge S Eurasian.
    Last edited by Zoro; 03-02-2021 at 03:37 PM.

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