Genes Matter: 8 Different Genetic Testing Companies Used

[VikLevaPatel]

For those of you who care. Just know that 23andme is selling your genetic data. The real money isn't made from selling kits but in selling data to huge Pharma companies. Stay woke
https://www.newscientist.com/article...its-users-dna/

Oh Jesus, Mary and Joseph! 8 different genetic testing companies have my data.

[VikLevaPatel]

According to the EasyDNA ANCESTRAL ORIGINS Report:

Each dot in the large population match map represents an individual population that the tested individual's genetic profile was
compared with. Hundreds of populations, comprising fifteen anthropological regions, are utilized to create this map.

ABOUT THE POPULATION MATCH MAP AND ITS STRENGTH INDICATOR GRAPH

Through several stages of analysis and statistical calculation that take genetic and anthropological factors into account,
populations that the tested profile is most likely to be genetically linked with become apparent. The populations with an
apparent link to the tested profile are indicated by highlighting them in green or yellow, depending on the strength of the link.

Each population's dot has a shape that indicates which anthropological region it belongs to. This, in addition to the color of the
population’s dot, allows the populations and regions that the tested individual is most closely related to - in a “geogenetic
sense” - to be seen at a glance.

The populations in the African Immigrant, European Immigrant, Asian Immigrant and Hispanic Immigrant anthropological
regions are known as “dispersed” populations, and indicate migration to North America from other native lands. Where
possible, they have been placed where they belong in North America. However, with the dispersed populations that appear in
the ocean, only the ethnicities of the people sampled and the fact that they are somewhere in North America is known, not
their current specific location.

The Population Match Map has a Strength Indicator Graph on the right side of the poster. Where the colors of dots in the
Population Match Map indicate the strength of each individual population, the bars in the population match strength indicator
graph display the overall strength of all the populations contained in each matched anthropological region in comparison with
other matched regions.

[VikLevaPatel]

My EasyDNA ancestry results:

Attachment 111188

The Regional Affiliation refers to the 15 anthropological regions currently included in the database (FoGG DB). The Number of Population Matches refers to the number of databases in the corresponding Regional Affiliation that rank as Good (Yellow Symbol) or Best (Green Symbol) on your unique map. Individuals that are known or suspected to be multi-racial may show a stronger linkage to a particular Regional Affiliation due to the statistical odds of genetic inheritance.

Region Defintions: Genetic Breakdown by Percent

Middle Eastern 0.03%
Ancestral Origins region "Middle Eastern" is a transcontinental region centered on Western Asia and Egypt in North Africa consisting of mainly Arabs, Turks, Persians, Kurds, and Azeris (excluding Republic of Azerbaijan). Minorities of the Middle East include Jews, Assyrians and other Arameans, Baloch, Berbers, Coptic Christians, Druze, Lurs, Mandaeans, Samaritans, Shabaks, Tats, and Zazas. Among other migrant populations are Bengalis as well as other Indians, Chinese, Filipinos, Indonesians, Pakistanis, and Sub-Saharan Africans.

North African 0.38%
Ancestral Origins region "North African" is a group of Mediterranean countries situated in the northern-most region of the African continent. It is defined as stretching from the Atlantic shores of Morocco in the west, to the Suez Canal and the Red Sea in the east.

Asian Dispersed 0.95%
Ancestral Origins region "Asian Dispersed" represents migration of peoples from the East Asian and South Asian regions to the North American regions.

European Dispersed 3.73%
Ancestral Origins region "European Dispersed" represents migration of peoples from the Northern and Southern European regions to the North American regions as well as migrants to Oceanic regions of Australia and New Zealand.

Southern European 8.74%
Ancestral Origins region "Southern European" is the southern region of the European continent. Most definitions of Southern Europe, also known as Mediterranean Europe, include the countries of the Iberian peninsula (Spain and Portugal), the Italian peninsula, Greece and Malta. The definition includes the entirety of Southeast Europe or the Balkan countries of Southeast Europe.

East Asian 22.82%
Ancestral Origins region "East Asian" is the eastern sub region of the Asian continent, which can be defined in either geographical or ethno-cultural terms.
Geographically and geopolitically, it includes China (including Hong Kong and Macau), Mongolia, Korea (North and South), Japan and Taiwan.

South Asian 31.36%
Ancestral Origins region "South Asian" is a term used to represent the southern region of the Asian continent, which comprises the sub-Himalayan SAARC countries and, adjoining countries to the west and east. Topographically, it is dominated by the Indian Plate, which rises above sea level as Nepal and northern parts of India situated south of the Himalayas and the Hindu Kush. South Asia is bounded on the south by the Indian Ocean and on land (clockwise, from west) by West Asia, Central Asia, East Asia, and Southeast Asia.

Northern European 31.98%
Ancestral Origins region "Northern European" is the northern part or region of Europe. It consists of European areas north of the Alpine region including (but not limited to) Iceland, the Republic of Ireland, the Isle of Man, the United Kingdom, the Faroe Islands, the Netherlands, Germany, Denmark, Norway, Sweden, Finland, Estonia, Latvia, Lithuania, Belarus and northwest Russia.

[VikLevaPatel]

European Dispersed 3.73%
Ancestral Origins region "European Dispersed" represents migration of peoples from the Northern and Southern European regions to the North American regions as well as migrants to Oceanic regions of Australia and New Zealand.

Southern European 8.74%
Ancestral Origins region "Southern European" is the southern region of the European continent. Most definitions of Southern Europe, also known as Mediterranean Europe, include the countries of the Iberian peninsula (Spain and Portugal), the Italian peninsula, Greece and Malta. The definition includes the entirety of Southeast Europe or the Balkan countries of Southeast Europe.

East Asian 22.82%
Ancestral Origins region "East Asian" is the eastern sub region of the Asian continent, which can be defined in either geographical or ethno-cultural terms.
Geographically and geopolitically, it includes China (including Hong Kong and Macau), Mongolia, Korea (North and South), Japan and Taiwan.

South Asian 31.36%
Ancestral Origins region "South Asian" is a term used to represent the southern region of the Asian continent, which comprises the sub-Himalayan SAARC countries and, adjoining countries to the west and east. Topographically, it is dominated by the Indian Plate, which rises above sea level as Nepal and northern parts of India situated south of the Himalayas and the Hindu Kush. South Asia is bounded on the south by the Indian Ocean and on land (clockwise, from west) by West Asia, Central Asia, East Asia, and Southeast Asia.

Northern European 31.98%
Ancestral Origins region "Northern European" is the northern part or region of Europe. It consists of European areas north of the Alpine region including (but not limited to) Iceland, the Republic of Ireland, the Isle of Man, the United Kingdom, the Faroe Islands, the Netherlands, Germany, Denmark, Norway, Sweden, Finland, Estonia, Latvia, Lithuania, Belarus and northwest Russia.

EasyDNA Region Defintions: Genetic Breakdown by Percent

Database Matches By Region

The following list of population databases indicate the closest matches to your unique DNA profile within each region.

Northern European
Irish, Caucasian - Dorset (UK), Swedish, Netherlands, Caucasian - United Kingdom, Scottish, German - Bavarian

South Asian
India - Karan, India - Kayasth, India - Brahmin, India - Rajput, India - Nepali, India - Golla, India - Gope, India - Bangladesh, India - Khandayat, India -
Tamil, India - General, India - Bhutia, India - Kayastha, India - Dhangar

East Asian
Asian - Guam, Chinese, Chinese - Macau, Taiwanese

Southern European
Italian, Portugese - Northern

European Dispersed
Caucasian Dispersed - Australia

[VikLevaPatel]

Since your signature cannot be longer than 500 characters excluding BB code markup.

Y-DNA (P): E1b1b (DNA Solutions Australia; DNA Diagnostics Center (DDC) Cincinnati OH).
mtDNA (M): W6 (DNA Solutions Australia; FTDNA; 23andMe).
Ancestry/Autosomal DNA/DNA Origins: 77% Ancient European (FTDNA).
ancientOrigins/Ancient European Origins: Metal Age Invader 67%, Early Farmer 10%, Hunter-Gatherer 0%, non-European 23% (FTDNA).
Ancestral Origins: Irish, Swedish, Scottish, German (Bavarian), Italian, Portugese, India (General), Kayastha, Karan, Brahmin, Rajput, Khandayat, Golla, Gope, Dhangar, Tamil, Nepali, Bhutia, Chinese, Taiwanese (EasyDNA).

EasyDNA Australia Ancestral Origin Discovery Upgrade test results:

CHART.jpg
bc676e0226774b7f862736a9f2a040e0-0003.jpg
northerneuropean.jpg

Kevin Alan Brook notes in Gujarati Genetics that "[o]n average, Gujaratis have 81.9% South Asian ancestry, 7.6% European ancestry, 4.9% Southeast Asian ancestry, 2.8% Austronesian ancestry, 2.3% West Asian ancestry, and 0.4% Northeast Asian ancestry, and most don't have any West African."

I'm way, way above average, in regard to European ancestry; and conversely, way, way below the average in regard to South Asian ancestry.

Northern European 31.98% (easyDNA Australia)
Southern European 8.74% (easyDNA Australia)
European Dispersed 3.73% (easyDNA Australia)
Total European Ancestry 44.45% (easyDNA Australia)
South Asian 31.36% (easyDNA Australia)
East Asian 22.82% (easyDNA Australia)
The results from 23andMe and ftDNA, however, show zero percent East Asian ancestry.
Origins: Asia 100%, Indian Subcontinent, Western India 100% (FTDNA)
Ancient European Origins (Autosomal DNA Results): 67% Metal Age Invader, 10% Farmer, 0% Hunter-Gatherer, 23% non-European (FTDNA)
99.6% Central and South Asian (23andMe)
99.6% Central Asian, Northern Indian & Pakistani (23andMe)
99.6% Gujarati Patidar (23andMe)
0.4% Sudanese (23andMe)
Asian Dispersed 0.95% (easyDNA Australia)
Middle Eastern 0.03% (easyDNA Australia)
North African 0.38% (easyDNA Australia)
0% Sub-Saharan African [AF] (DDC; easyDNA Australia)
0% East Asian [EA] (DDC)

DDC (DNA Diagnostics Center) DNA REPORT: GetFileAttachment_pages-to-jpg-0001.jpg

Maternal Haplogroup W6 (23andMe)
Paternal Haplogroup C-Z5896 (23andMe) [Y-SNP]

Confirmed mtDNA Haplogroup W6 (FTDNA)
Confirmed Y-DNA Haplogroup C-K466 ​(FTDNA) [Y-SNP]

We ought to note that the boundary between Asia and Europe has no official line, so the definition of "Asian" may include Central Asians, East Asians, Native Hawaiians and Pacific Islanders, Southeast Asians and South Asians, as well as West Asians.

In The Prodigal Tongue: The Love-Hate Relationship Between American and British English, Murphy writes about a British journalist whose use of the word “means ‘from the Indian subcontinent,’ and so when he wants to talk about people from China, Korea, or Japan, he [says] east Asians. In America, the situation is just the opposite: say Asian and people assume ‘east Asian.’ When people mean ‘south Asian,’ they’ll probably say Indian or maybe South Asian.”

https://archive.md/BVXhB#selection-1025.0-1029.370

[VikLevaPatel]

Of course, there is no such thing as the perfect DNA test, and there has always been the problem of whether the lab performed the genealogical DNA test accurately.

CRI+Genetics+review+table.jpg

The results should be taken with a grain of salt, for obvious reasons.

Multiple DNA testing companies need to be used and the results need to be compared, in order to produce comparable and compatible findings and conclusions.

Ethnicity results on 24Genetics: https://archive.md/KLsnY

I just ordered my last DNA test kit (the ninth, and last in the list) from 24Genetics.

Express Shipping FedEx, DHL or similar. Kit return included.

How accurate is 24Genetics? Very accurate. Unlike some DNA tests, 24Genetics sequences and stores your whole genome, meaning it's very accurate. What's more, the ancestry DNA test analyzes 700,000 genetic markers and coveres more than 1,000 geographical regions.

https://archive.md/XJZzH

Overall, I feel like my top most results from this company are accurate but it's missing significant locations and the smallest percentages are likely just noise. An interesting assessment, especially the more specific break down that you don't always get from other companies, but as with any ethnicity report, don't take it too literally.

https://archive.md/UqIDk#selection-675.1-675.341

It’s estimated the industry will be worth a staggering £7.7bn by 2022; in the last year alone, market leader AncestryDNA pulled in $1bn in revenue.

https://archive.md/SBRSv#selection-1127.28-1139.27

Privacy is a major concern for everyone using these sites, but perhaps more so for those from minority backgrounds. For those who are already discriminated against, having their genome used against them – for example, in the criminal justice system – could have serious implications. An internal report revealed that in 2017, AncestryDNA received 34 law enforcement requests, and provided information to 31.

https://archive.md/SBRSv#selection-1279.0-1279.605

There’s also the question of just how much information is passed down through a person’s DNA. Thomas explains that we probably inherit very few genes from our ancestors; DNA is inherited in “chunks” that break up the further back in time you go. “You start with two parents, then four grandparents, then eight great-grandparents, it goes to 16, 32 and so on. And by the time you go 10 generations back, there are ancestors from whom you inherit no DNA.”

https://archive.md/SBRSv#selection-1313.0-1313.453

[VikLevaPatel]

The results should be taken with a grain of salt, for obvious reasons. Multiple DNA testing companies need to be used and the results need to be compared, in order to produce comparable and compatible findings and conclusions.

Knowledge is most definitely power.

23andMe had devastating news about my health. I wish a person had delivered it:

To my utter shock, the results showed that I have a mutation in a gene called BRCA1, which puts me at a huge risk of developing breast and ovarian cancer. I broke into tears.

At first, I didn’t believe what I was seeing. My father’s sister died of breast cancer when she was 37, but her mother (my grandmother) and her sisters all lived long healthy lives. My aunt’s death was always talked about as an unforeseeable tragedy, not a family legacy. I knew that being an Ashkenazi Jew (100%, according to 23andMe) put me at a higher risk of BRCA but at 1 in 40 that’s still only 2.5% of my tribe.

https://archive.md/VTC5U#selection-1379.0-1387.36

Home testing: a parlor game?

On every step of this journey, I was aware of one glaring fact: All of this would have been infinitely more difficult if I had to do it while also fighting cancer.

23andMe says its mission is to empower users with information, and I did feel empowered. If I hadn’t taken the at-home test, I likely would not have seen a doctor and a genetic counselor and had my genes tested. And instead of being able to take preventive action, I would probably have ended up undergoing the same surgeries but with the added complications that come with chemotherapy. In that sense, I am infinitely thankful that at-home genetics tests are cheap and available to people like me.

But with the growth of DNA testing, it can feel like we’re treating serious medical diagnoses as a parlor game, and that’s frightening. As scary as it is to get the news that you have a mutation, getting a clean bill of health from 23andMe could potentially be worse. While the company is quite clear that it tests for only three variants in the BRCA1 and BRCA2 genes, it points out that there are more than 1,000 variants in these genes that can elevate individuals’ cancer risks. In other words, a report from 23andMe showing that you don’t have a BRCA mutation doesn’t necessarily mean you’re in the clear.

“That’s where I see potential downfall,” says John E. Lee, program manager at the Genetic Counseling Clinic at Cedars-Sinai. “For the three variants they test for, they’re very accurate, but they’re not looking at the rest of the genes” that can lead to breast or ovarian cancer.

https://archive.md/VTC5U#selection-1603.0-1603.28

[Turul Karom]

A chargeback (over 700 AUD) has been filed, and I would not recommend them. There's no phone number to contact them and unlike most other DNA testing companies, they do not use the best delivery options for international packages (FedEx, UPS, DHL).



I have been informed that USPS has stopped and suspended all services to various foreign countries including Australia.

Compare this with my latest order (over a thousand dollars and the last one in the list) from Genetrack Biolabs based in Vancouver, British Columbia. Top Notch Service. I received my kit within a few days (via FedEx Express)!

If you are trying to do a full genome sequence, use sequencing.com

They are much better.

[VikLevaPatel]

How in the hell did I get such a high EasyDNA East Asian reading (22.82%).

In any case, the highest component is Northern European (31.98%), followed by South Asian (31.36%).

So anyway you look at it, a large majority, almost 70 percent, of my ancestry comes from outside of South Asia or the overwhelming majority of it is not Indian or South Asian.

ancestralorigins.jpg
ancestralorigins2.jpg
ancestralorigins3.jpg

East Asian Group 1E
Northern European Group 3N
Northern European Group 2N

ABOUT THE NATIVE REGION MATCH MAP AND ITS STRENGTH INDICATOR GRAPH
A modified set of analyses and statistical calculations have been performed to identify the so-called “Native Regions” of the
tested genetic profile. Most people will only have one or two regions. These anthropological regions indicate a more “deep
roots” match than does the Population Match, and as such there are no “dispersed” anthropological regions indicated on this
map. If there is more than one match, the strongest match is indicated in green, the rest in yellow.

Your STR PROFILE is a permanent means of
individual identification. Unlike a name that may be
shared, an identification card number that can be
stolen, or photographs that change over time, your
personal DNA identity remains constant from the
moment of conception to the end of life. Your profile
demonstrates your genetic similarity to family
members as well as the genetic uniqueness that
distinguishes you from the rest of the world. Should
you or your family need help from a law enforcement
agency – such as in search for a missing person due
to abduction, accident, or a natural disaster – your
profile is fully compatible with the internationally
recognized DNA identity standards.

UNDERSTANDING MIGRATION
It is not uncommon to find some surprises in your Ancestral Origins map. One key to understanding your unique geogenetic
makeup is to understand the history of human migration and how natural migrations along with conquest and discovery have
contributed to the mixing of people and nations. Human migration is movement (physical or psychological) by humans from
one district to another, sometimes over long distances or in large groups.
The movement of populations in modern times has continued under the form of both voluntary migration within one's region,
country, or beyond, and involuntary migration (which includes the slave trade, trafficking in human beings and ethnic
cleansing). People who migrate are called migrants, or, more specifically, emigrants, immigrants, or settlers, depending on
historical setting, circumstances and perspective.

Compare this with:

FTDNA

All Origins Percentages
Asia 100%
Indian Subcontinent 100%
Western India 100%
Eastern India 0%
Northern India 0%
Southern India 0%

23andMe

Central Asian
0.0% Central Asian
Chinese
0.0% Chinese
Chinese Dai
0.0% Chinese Dai

Your ‘Ethnicity Estimate’ Doesn’t Mean What You Think It Does
The limits of ancestry DNA tests, explained

So what accounts for these differences? Overall, discrepancies in ancestry testing don’t mean that genetic science is a fraud, and that the companies are just making up these numbers. They have more to do with the limitations of the science and some key assumptions companies make when analyzing DNA for ancestry. What’s not always obvious from these reports is that they’re based on estimates that can vary from company to company, and have built-in sources of error. Your results from one company can even change over time as the company signs up more users, and gathers more data.

The issue with "inaccuracy" in DNA ethnicity reports doesn’t have anything to do with your actual DNA. Rather, it has to do with how your DNA is interpreted and presented by the companies providing your results. Each of these companies uses software to compare your information to that of available sample populations in their databases – and it is in the way that these available sample populations are structured, their availability (or lack thereof), how they relate to each other and how the company chooses to present this information to you that causes confusion. This can be demonstrated by looking at several tests from different companies for the same individual.

[Leto]

So what accounts for these differences? Overall, discrepancies in ancestry testing don’t mean that genetic science is a fraud, and that the companies are just making up these numbers. They have more to do with the limitations of the science and some key assumptions companies make when analyzing DNA for ancestry.

What do your Gedmatch results show? Can you show me Dodecad K12b, Harappa World, Eurogenes K13? The components especially.