POST PERSONAL DNA/GENETIC REPORTS

[VikLevaPatel]

I cant believe how accurate the report is. To A Tee...

Athletic Performance: Results (sequencing.com)

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Your genes can affect many aspects of your health, including your potential to excel at specific workouts and sports. The genetic testing results below allow you to personalize your physical fitness routine in-order to help you reach your fitness and wellness goals.

Genetic testing for athletic performance focuses on a gene that determines your muscle fiber type. A number of different genes that are associated with exercise-induced fatigue and exercise-iinduced muscle damage have also been analyzed.

You are likely to excel at power-based sports and physical activities. This doesn’t mean you can’t play or excel at endurance-based sports, only that when participating in endurance-based sports you are more likely to experience fatigue and muscle pain earlier and more intensely than people predisposed to those endurance sports.

A number of genes were assessed and you are not genetically predisposed to becoming abnormally fatigued while exercising.

You do not have sickle cell trait and are not at risk of exercise-induced muscle damage due to this specific trait.

Your Athletic Predisposition

Your genes indicate that you are more likely to excel in sports requiring physical power and strength. These activities include:

 Five to ten minutes intervals of intense exercise on cardio equipment
 Resistance and weight training
 Short distance running and sprints
 Short distance swimming
 Gymnastics, wrestling, and boxing
 Ice hockey, soccer, volleyball, tennis, archery, and downhill skiing

Based on your genes, you are less likely to excel at sports that require endurance. These activities usually involve low to medium physical exertion and last longer than 20 minutes without rest. They include:

 Using cardio equipment, such as the elliptical, treadmill, Stairmaster, or rowing machine for longer than 20 minutes without a rest
 Long distance and marathon running
 Long-distance swimming
 Rowing, kayaking, and canoeing
 Hiking, mountaineering, and cross-country skiing
 Triathlons such as Ironman competitions

You are not predisposed to an abnormal amount of exercise-induced fatigue.

While everyone has the potential to become tired after prolonged exercise, you most likely will not experience an abnormal amount of fatigue.

You do not have sickle cell trait.

[VikLevaPatel]

Genomelink: Childhood Intelligence

You have a stronger tendency for having high childhood intelligence

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Intelligence in childhood, as measured by IQ tests, is correlated with important outcomes in later life, such as educational attainment, income, and health. The referenced study on children aged 6-18 years old found that while no single SNP could explain variance in childhood intelligence independently, the aggregate effect of an array of SNPs predicted 22-46% of variance in childhood intelligence.

https://genomelink.io/dashboard/childhood-intelligence/

Reference papers and your DNA

Childhood intelligence is heritable, highly polygenic and associated with FNBP1L.
Benyamin B et al. 2014

This is the first report of a genome-wide association study (GWAS) on childhood intelligence from 17,989 individuals in six discovery and three replication samples. The meta-analysis identified 18 independent genome-wide significant loci. FNBP1L, previously reported to be the most significantly associated gene for adult intelligence, was also significantly associated with childhood intelligence.

www.ncbi.nlm.nih.gov/pubmed/23358156

[VikLevaPatel]

Corona virus COVID-19 genetic susceptibility report

Use this free test to understand what role your genes may play in influencing your response to Corona virus.

https://www.yourdnaportal.com/cor

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yourDNAportal.com does not diagnose any medical condition. This test is not diagnostic test. It is essential that you do not make a decision on your health or that of your family based on this test. If you are concerned or have questions about what it means for you and your family you must consult with your doctor or a professional healthcare provider. Make sure you follow your government's advice on COVID-19.

Your results

Nasopharyngeal shedding of severe acute respiratory syndrome-associated coronavirus is associated with genetic polymorphisms.

rs1800587GG: People with your genotype may have a lower chance of developing a corona virus infection.

References:
https://www.ncbi.nlm.nih.gov/pubmed/16652313

Interleukin-10 (anti-inflammatory cytokine) - Risk of respiratory infection.

rs1800795GG: People with your genotype have a greater chance of infection.

References:
https://www.researchgate.net/publica...ovirus_Illness
https://www.nature.com/articles/srep35021

rs1800871AG: People with your genotype have a greater chance of infection.

References:
https://journals.plos.org/plosone/ar...l.pone.0140799
https://www.ncbi.nlm.nih.gov/pubmed/21829141
https://www.ncbi.nlm.nih.gov/pubmed/16860701
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884322/

rs1800872GT: People with your genotype have a slightly increased risk of infection.

References:
https://journals.plos.org/plosone/ar...l.pone.0140799
ps://www.ncbi.nlm.nih.gov/pubmed/21829141
https://www.ncbi.nlm.nih.gov/pubmed/16860701

rs1800896TT: People with your genotype have an increased risk of infection.

References:
https://journals.plos.org/plosone/ar...l.pone.0140799
https://www.ncbi.nlm.nih.gov/pubmed/21829141
https://www.ncbi.nlm.nih.gov/pubmed/16860701
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884322

rs3024505GG: People with your genotype have a slightly reduced risk of infection.

References:
https://pubmed.ncbi.nlm.nih.gov/31570879/
https://journals.plos.org/plosone/ar...l.pone.0140799
https://www.ncbi.nlm.nih.gov/pubmed/21829141
https://www.ncbi.nlm.nih.gov/pubmed/16860701
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884322/

Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes.

rs2660AG: People with your genotype carry one marker that may increase your chance of developing a corona virus infection.

References:
https://www.ncbi.nlm.nih.gov/pubmed/16390004
https://www.ncbi.nlm.nih.gov/pubmed/15766558
https://www.ncbi.nlm.nih.gov/pubmed/16824203

Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection.

rs1800450CC: People with your genotype may have a lower chance of developing a corona virus infection.

References:
https://www.ncbi.nlm.nih.gov/pubmed/16170752
https://www.ncbi.nlm.nih.gov/pubmed/15838797

[VikLevaPatel]

The yourDNAportal report's pretty much accurate.

https://www.yourdnaportal.com/yourhealthrisks

Type 2 Diabetes
Genotype: CC
Gene: SLC30A8
People with your genotype are at increased risk for type-2 diabetes

Maintaining a healthy weight and exercising may improve outlook. (CC) 3 increased risk for type-2 diabetes.

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Diabetes runs in the family. So it's no surprise then that I've inherited this sh*tty gene.

[VikLevaPatel]

tellmeGen: https://genportal.tellmegen.eu/

TECHNICAL REPORT
SNP: rs6746030
Gen or Region: SCN9A

GENOTYPE
GG
RESULT
Decreased pain sensation to nociceptive stimuli.

It is well known that people differ widely in sensitivity to pain. At one end of the spectrum people can easily support the sensations that most people would consider unbearable; on the other, people feel more pain than normal. Although little about the specific genes that are involved are known, it appears that there is a substantial genetic component to pain sensitivity.

SNP rs6746030 is the one located in the Nav1.7 sodium channel (SCN9A) gene

In five cohorts analyzed, with a total of 1,277 individuals, the allele less frequent rs6746030 (A) was associated with increased pain (P = 0.0001).

Bibliography

Reimann F, Cox JJ, Belfer I, Diatchenko L, Zaykin D V, McHale DP, et al. Pain perception is altered by a nucleotide polymorphism in SCN9A. Proc Natl Acad Sci U S A. 2010;107(11):5148–53.

Pain Sensitivity

Pain is a subjective and complex sensation; it can be throbbing, intense, slight or even burn. Knowing how to distinguish these different forms is crucial for its treatment since it hints at the cause of the pain and where it is coming from. Pain can be classified as nociceptive pain (inflammatory), neuropathic (nerve related origin), psychogenic (associated with psychologicalfactors) according to its cause and location.

Each person perceives pain differently. It is also important to note that there is a perceptible difference in pain sensitivity between men and women. Contrary to what is believed, women are usually more sensitive to pain mainly because of their sexual hormones and cultural and social influence.

Estrogens influence pain sensitivity in women because they increase the levels of alertness and activity in the nervous system and therefore, pain transmission. In addition, men have the advantage of the male sexual hormone, testosterone, which reduces sensitivity to pain.

A new study carried out by researchers at King College of London showed that pain sensitivity could be altered by a person’s life style and surroundings. Their research is based on the discovery that pain sensitivity, previously considered inflexible, can change as a result of a gene “switching off” or “switching on”, that is, of the expression of the genes according to life style and environmental factors in a process known as epigenetics, in charge of the chemical alteration of the genes.

This research has been published in the magazine “Nature Communications” and has important implications for understanding pain sensitivity and could lead to new treatments directed towards “turning off” certain genes epigenetically.

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[VikLevaPatel]

tellmeGen: MY RESULTS / TRAITS: Skin pigmentation

Less likely to have light skin

https://genportal.tellmegen.eu/results/traits

TECHNICAL REPORT

SNP: rs1426654
Gen or Region: SLC24A5

SNP USED: rs1426654
GENOTYPE: AA
RESULT: High likely to have light skin

SNP: rs16891982
Gen or Region: SLC24A5

SNP USED: rs16891982
GENOTYPE: CC
RESULT: High likely to have dark skin

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The colour of the skin is determined by the melanosomes, intracellular organelles of the melanocytes that contain melanin. This brown-black pigment is responsible for absorbing UV radiation and transforming it into callous. The colouring of the skin is determined by the number, size, and shape of the melanosomes and the amount and type of melatonin. Although some genes that contribute physiologically to skin colour have been described, the SLC24A5 gene has been cataloged as the most important.

The SLC24A5 gene (located on the long arm of chromosome 15) encodes for the NCKX5 protein, a membrane transporter of the Na-K exchanger family located in the Golgi apparatus of melanocytes and involved in melanin biosynthesis. Disruption studies show how the elimination of this protein causes a significant reduction in melanin biogenesis.

The rs1426654 variant of the SLC24A5 gene, also known as c.331A>G or p.Thr111Ala, is directly related to the determination of skin colour. In particular, the A allele is associated with a lighter skin phenotype and is characteristic of Europeans and Western Asians. In contrast, the G allele is associated with a darker skin tone and is more present in Asian or African individuals.

The other variant of the same gene analysed, the rs16891982, also known as c.1122G>C or p.Leu374Phe, is also associated with skin colour. In this, the G allele (oriented according to dbSNP) is associated with light skin colour and is typical of European descent, whereas the C allele is associated with a dark colour and is especially frequent in the African and South Asian population.

Bibliography

Valenzuela R. et al. Predicting phenotype from genotype: normal pigmentation. J Forensic Sci. 2010 Mar 1;55(2):315-22.

Beleza S. et al. Genetic architecture of skin and eye color in an African-European admixed population. PLoS Genet. 2013 Mar;9(3):e1003372.

Lamason R. et al. SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. Science. 2005 Dec 16;310(5755):1782-6.

so you're telling me... you're highly likely to have both light skin and dark skin



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[ANXIETY (ADEPT)]

No reports on your haplogroup? haha