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Thread: Origin and ancient History of red hair

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    Veteran Member Annihilus's Avatar
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    Quote Originally Posted by Graham View Post
    It comes from BritainDna, Allice already posted that map a few pages before Jackson.

    Here is some information of the test.. http://www.britainsdna.com/products/red-head
    rs1805007 is on MC1R and 23andme tests 15 snp's, but they only link this one to redhair. Interesting to know which ones they test overlap with 23andme.

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    Made a thread on that Anni. You should post your results also.
    http://www.theapricity.com/forum/sho...ight=rs1805007

    Btw my cousin, on my Dad's side is a proper redhead. So the gene runs on his side.

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    I carry the red hair gene and the highest amount of red-haired people are in Russia and not in Scotland or Ireland like many believe and I have R1b matches in Germany and England which is interesting? My Great Grandpa had natural red hair with amber eyes which is uncommon among us Indians. While me, my dad and Grandpa just have chestnut ginger hair in our beards and my surname is Khaira, which is an odd surname for an Indian.


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    Quote Originally Posted by Smeagol View Post
    The Udmurts have the highest percentage of red hair, 14% I think.
    Urdmurtian minorities do have a high frequency of red hair that's true. However, Northwestern Europe especially the British Isles show a concentration of red hair which is unequalled.
    Ireland = 10% - 30%
    Scotland = 10% - 25%
    Wales = 10% - 15%
    England = 8%
    Iceland = 6%
    Norway = 5%
    Belgium = 4%
    Denmark, Sweden, France = 3%
    The Netherlands = 2.5%
    Germany, Austria, Finland = 2%

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    My hair has lots of red in it and my kids have golden-strawberry blonde hair, but I do not have the red hair gene. It baffles me.

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    Quote Originally Posted by Fire Haired View Post
    Spoiler!
    I think this pic is wrong, they are both Etruscans....

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    Quote Originally Posted by MinervaItalica View Post
    I think this pic is wrong, they are both Etruscans....
    Yes, they are both Etruscans. The pic is a bullishit.

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    Quote Originally Posted by Starseed88 View Post
    I carry the red hair gene and the highest amount of red-haired people are in Russia and not in Scotland or Ireland like many believe and I have R1b matches in Germany and England which is interesting? My Great Grandpa had natural red hair with amber eyes which is uncommon among us Indians. While me, my dad and Grandpa just have chestnut ginger hair in our beards and my surname is Khaira, which is an odd surname for an Indian.
    Are you from northern India? Most probably you have ancestors from White Huns (Akhuns) that conquered and ruled the area for more that 150 years, they were described as red and blonde haired with blue eyes etc, like the Kushan before them. Kaira or Kayra is the name of main god (Tengri) of proto-Turks and Turkic peoples

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    The MC1R gene provides instructions for making a protein called the 1 melanocortin receptor, which produces two forms of melanin, eumelanin and pheomelanin. These MC1R genes reduce the ability of the melanocortin 1 receptor to stimulate eumelanin production, causing melanocytes to make mostly pheomelanin. People who produce mostly pheomelanin tend to have red or blond hair. Individuals with two MC1R alleles are generally red heads, and persons with 0 or 1 MC1R alleles are rarely red heads. MC1R variants are also linked to increased melanoma risk (Robles-Espinoza et al. 2016).


    Melanocortin 1 receptor (MC1R) is a G protein-coupled receptor expressed on the surface of melanocytes that signals to downstream effectors, such as the microphthalmia-associated transcription factor, to regulate skin pigmentation and to control cell proliferation and apoptosis1. Melanin is generated by melanocytes in two major forms, pheomelanin and eumelanin. Unlike eumelanin, which is dark brown or black in colour, pheomelanin is red/orange, and is associated with type I/II skin, freckles, red hair and an inability to tan2. People with this phenotype are generally highly photosensitive, and prone to sunburn when exposed to ultraviolet (UV) light3.

    Population sequencing studies have revealed a number of null or hypomorphic MC1R alleles, which are collectively referred to as R alleles and are strongly associated with the red hair and light skin phenotype4,5. Other missense variants are referred to as r alleles and are less strongly associated with this hair colour and complexion4,6. While R/R individuals are generally red heads, and persons with 0 or 1 R alleles are rarely red heads, pigmentation traits such as degree of tanning after repeated UV exposure3 and skin reflectance7 depend additively on the number of R alleles. In addition to regulating skin pigmentation, MC1R signalling has been reported to increase phosphorylation of DNA repair proteins, initiating the DNA damage repair process, and also to activate survival pathways8,9,10,11. As such, polymorphisms in MC1R have been linked to increased melanocyte apoptosis and inefficient DNA repair12. Collectively these factors link MC1R variants to increased melanoma risk6,13,14. In animal model systems, null alleles of Mc1r (Mc1re/e) have been shown to co-operate with BrafV600E to promote melanoma development via mechanisms including enhanced lipid peroxidation, a phenotype rescued on an albino mouse background owing to a lack of pheomelanin production15. This has led to the suggestion that loss of MC1R function, even in the absence of UV light, may be oncogenic. Despite these insights, it is still unclear whether MC1R germline variant alleles influence the genome-wide somatic mutation burden in melanoma.

    In this study, we set out to establish the contribution of germline MC1R alleles to the somatic mutation landscape of sporadic melanoma. Mutations found in melanomas are predominantly C>T transitions due to the production of cyclobutane pyrimidine dimers (CPDs) in response to solar UV damage, but other mutational classes such as C>A transversions have also been observed16,17,18,19,20. Indeed, hotspot mutations in key driver genes, such as BRAF and KIT, are almost exclusively acquired as non-C>T mutations17. Our results indicate that individuals with one or two germline MC1R R alleles have a significantly higher somatic mutational load than individuals with no R alleles. This finding has implications for our understanding of melanomagenesis, as well as the identification of individuals at higher risk of developing melanoma.

    https://www.nature.com/articles/ncomms12064

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    Quote Originally Posted by Artek View Post
    I have no doubt that those maps are biased.
    Oh believe me they always are, most of these Hair Colour, Eye Colour etc maps have no source attached to them and are made by pseudo-anthro-tards that think that "The Further South you go the less likely you are to have Redhair so make it very unlikely" - when the actual truth is that it's more widespread than people believe, there is however, a certain point where it becomes unlikely but I know for a fact that Redhair is common among Levantines, many Syrians, Lebanese, Ashkenazi Jews, Sephardic or Mizrahim also have Redhair.

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