Even minimal exposure to Aluminum through vaccines can provoke autoimmune disordersExperimental evidence shows that simultaneous administration of as little as two to three immune adjuvants, or repeated stimulation of the immune system by the same antigen, can overcome genetic resistance to autoimmunity.5
Aluminum adjuvants have a potential to induce serious immunological disorders in humans. In particular, aluminum in adjuvant form (from vaccines) carries a risk for autoimmunity, long-term brain inflammation and associated neurological complications and may thus have profound and widespread adverse health consequences.4
Vaccines can induce the appearances of autoantibodies, enigmatic inflammatory condition, and overt autoimmune disease. Of which, non-specific manifestations such as arthritis, neuronal damage, fatigue, encephalitis and vasculitis were frequently described.26
A variety of conditions encompassed by the 'Autoimmune/inflammatory syndrome induced by adjuvants' (ASIA) have been linked to exposure to aluminum (Al) vaccine adjuvants. These conditions include: Siliconosis, the Gulf war syndrome (GWS), the macrophagic myofasciitis syndrome (MMF), and post-vaccination phenomena. Furthermore, these four diseases share a similar complex of signs and symptoms: Myalgia (muscle pain), myositis (inflamed, damaged muscles) or muscle weakness, arthralgia (pain in joints) and/or arthritis (inflammation of joints), chronic fatigue, un-refreshing sleep or sleep disturbances, neurological manifestations (especially associated with demyelination (degeneration of nerves)), cognitive impairment, memory loss, pyrexia (fever), dry mouth, appearance of auto-antibodies or antibodies directed at the suspected adjuvant, irritable bowel syndrome, evolvement of an autoimmune disease (i.e. Multiple Sclerosis).5
Recently, autoantibody, production was studied in 92 healthy medical workers after influenza vaccination. For subjects with autoantibodies before vaccination, increased titers were documented 1 and 6 months post-vaccination in 11% and 13% of them respectively. Moreover 4 participants developed de novo (new) autoantibodies 6 months after vaccination, one of them with very high titers alluding to a possible long-lasting effect. In addition to the appearance of autoantibodies, clinical presentations or mild exacerbations of an autoimmune disease were occasionally observed following vaccinations. Autoimmune diseases develop in individuals who are genetically susceptible after their immune system is triggered (i.e., by infection or vaccine). Avoiding such a triggering stimulus may allow an individual to remain asymptomatic throughout his or her life.24
The increased risk of autoimmunity among recipients of a certain vaccine may stem not only from its antigenic-mediated responses but also from other constituents of the vaccine, such as yeast, adjuvant and preservative. For example adjuvants have been added to vaccines to improve their immunogenicity. However, alongside their supportive role they were found to themselves inflict an illness of autoimmune nature, defined as "adjuvant disease".24
Influenza vaccine, like most human vaccines, is capable of inducing immune responses and includes also an adjuvant and other components that can increase its autoimmune pathogenicity (ability to cause harm). Thus, for the minority of individuals who are probably genetically susceptible, as well as for patients with active Systemic lupus erythematosus (SLE) disease, the influenza vaccine, among others, may trigger an overt autoimmune disease.24
The latency period between immunization and autoimmunity ranges between days to years. An individuals susceptibility (for example, relating to genetic factors) might have an important role in vaccine–autoimmunity interactions.25
Aluminum has a range of mechanisms inwhich it causes inflammation: 27
- Aluminum is a pro-oxidant (induces oxidative stress) which inturn induces an inflammation response.
- Aluminum induces an inflammation response known as NALP3 inflammasome (associated with autoimmune disease).
- Aluminum itself can be antigenic (elicits the response of antibodies).
Aluminum (found in vaccines) is a potential factor for the induction of inflammation in Crohn's disease (chronic inflammation of the intestines), and its immune activities share many characteristics with the immune pathology of Crohn's disease. The Crohn's disease mucosa is confronted with numerous inappropriate bacterial components adsorbed on the aluminum compound surface, constituting a pro-inflammatory supra-adjuvant. Aluminum fits the diagnostic criteria of the newly described autoimmune/inflammatory syndrome induced by adjuvants (ASIA).34
Other studies correlating Aluminum with illnessMacrophagic myofasciitis (MMF) is characterized by specific muscle lesions with long-term persistence of aluminum hydroxide at the site of previous immunization. Macrophagic myofasciitis lesions show an ongoing local immune reaction, and are detected in patients with systemic symptoms which appeared subsequently to vaccination. Affected patients mainly complain of arthromyalgias (joint and muscle pain), chronic fatigue, and cognitive difficulties. One-third of patients with macrophagic myofasciitis develop autoimmune disease.17, 18, 19
In preterm infants, prolonged intravenous feeding with solutions containing aluminum is associated with impaired neurologic development.We estimate that for infants receiving full intravenous feeding (approx 180ml per kilogram every 24 hours) with a mean aluminum intake of 45μg per kilogram per day, the expected reduction in the Bayley Mental Development Index (a score of 50 to 150) would be, on average, one point per day of intravenous feeding. The former (infants who received an intravenous feeding solution with higher amounts of aluminum) were significantly more likely (39 percent, vs. 17 percent of the latter group; P = 0.03) to have a Mental Development Index of less than 85, increasing their risk of subsequent educational problems.28
Young, male colony CD-1 mice were injected with the (aluminum) adjuvants at doses equivalent to those given to US military service personnel. Subsequent testing showed:
- Motor deficits expressed as a progressive decrease in strength (50%).
- Significant cognitive deficits in water-maze learning (4.3 vs 0.2 errors per trial).
- Significant motor neuron loss in the lumbar spinal cord (35%).
- Significantly increased numbers of astrocytes (cells that are expressed when the nervous system is injured and needs repair) in the lumbar spinal cord (350%).
- Significantly increased activated caspase-3 (protein that promotes programmed cell death) labeling in lumbar spinal cord (255%) and primary motor cortex (192%).
The findings suggest a possible role for the aluminum adjuvant in some neurological features associated with Gulf War Illness (GWI).29
Vaccine-exposed and saline-injected control infants (macaques) underwent MRI and PET imaging at approximately 4 and 6 months of age, representing two specific timeframes within the vaccination schedule. Maturational changes in amygdala (part of the brain involved in processing and expressing emotions) volume was significantly altered in infant macaques receiving the vaccine schedule (the complete US vaccine schedule that was given in 1994-1999).30
We conclude that exposure of Hepa1-6 cells (mouse liver cells) to a low dose of (aluminum) adjuvanted hepatitis B vaccine leads to loss of mitochondrial integrity, apoptosis (programmed cell death) induction, and cell death.31
Studies show Aluminum is also correlated with AutismAluminum (Al), the most commonly used vaccine adjuvant, is a demonstrated neurotoxin and a strong immune stimulator. Hence, adjuvant Al has the potential to induce neuroimmune disorders. Our results show that:
(i) children from countries with the highest ASD prevalence appear to have the highest exposure to Al from vaccines;
(ii) the increase in exposure to Al adjuvants significantly correlates with the increase in ASD prevalence in the United States observed over the last two decades (Pearson r = 0.92, p < 0.0001); and
(iii) a significant correlation exists between the amounts of Al administered to preschool children and the current prevalence of ASD in seven Western countries, particularly at 3–4 months of age (Pearson r = 0.89–0.94, p = 0.0018–0.0248).
The data indicates that the correlation between Al in vaccines and ASD may be causal.12
Do vaccines cause autism? (must see)
Reply With Quote
Originally Posted by iNird
Bookmarks