"Around the same time, a GWAS of 9,747 Caucasian BD patients and 14,278 controls identified a novel risk locus at the same intergenic region8. The lead SNP, rs12202969, was associated with ∼10-20% increased risk for BD. Another GWAS study of BD confirmed this signal10. A third GWAS of 9,784 Caucasian BD patients and 30,471 controls pinpointed the proxy variant rs1487441 (r2 = 0.98 with rs12202969)9.
We observed that the two BD GWAS lead SNPs (rs12202969 and rs1487441) were in high LD with the lead SNPs in the GWAS’s of educational attainment and cognition (rs9320913, rs1906252, and rs104757441) (pairwise r2 = 0.92-0.99), suggesting a shared genetic basis for cognitive performance and BD (Table S1). Intriguingly, the variants associated with enhanced cognitive performance were associated with increased BD risk, consistent with the finding that children with higher IQs are at higher risk for developing manic features"
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