Nebula results soon

[Flashball]

Nice. One question though, isn't genetic testing illigal in France?

It was already in 2016, when I ordered an FTDNA kit... but the government was more flexible? It seems (maybe) however that it is Myheritage who decided to stop for France, for 23andme I don't know.

Anyway, I'll post all the results here.

[Flashball]

[Flashball]

Y DNA:
I am R-FT288677 (u106 sub-branch)
As you can see I'm the ID YF114365 and there's another guy who has the same sub-branch (ID YF084402)



Maternal haplogroup:

[Flashball]

Good
50gb bam file converted into multitudes of raw data

The rar file is 1.5 GB in total, I'm downloading it right now


I don't expect to find my entire genome contained in a single raw data file, however I think there will likely be more SNPs in it than contained in the current raw data version of 23andme.

[HannibaltheGreat]

How is Yseq WGS++ conpared to Nebula?

[Flashball]

How is Yseq WGS++ conpared to Nebula?

I believe however considering the price, this is 100x whole genome sequencing, so it could be better than 30x (although that is already very good).

The difference can be located here I think:

"The YSEQ analysis does not contain any medical relevant information since the purpose is genealogy. But of course health related information is contained in the raw data and can be extracted from a third-party expert"

In the case of Nebula, there is information for health.. but it is relatively basic (not always), however they update via new studies (for certain diseases and others), which is very good .

The genome exploration interface on the Nebula site is also very good, relatively simple, very easy to find an SNP without going through the raw files.

In both cases, you can extract your raw data and derive more benefit from it, so don't worry.

I believe the price for 100x whole genome sequencing is about the same on Nebula, though you might find more promotion there I think, but that might be the case on yseq as well

Nebula customer service is pretty quick to respond, in my case I had a very active follow up. I had been told the steps, that some steps took longer than others (quality control much longer than sequencing, which only takes few day in my case).

I had no problems with Nebula, even when my kit took longer than expected to arrive: I contacted customer service and they answered me right away.



For YSEQ raw data extraction, there seems to be something more: they offer to convert your raw data into gedmatch (and others) compatible data, I guess?

You have to pay extra, but honestly, it would take less time to pay than doing it yourself (download 100-150 GB BAM). There is the VCF too, but I don't know if it's the same to convert a VCF to gedmatch compatible raw data, I had tried and the quality was lower than what 23andme offered, i.e. there were less Snps!!!

Nebula account offers this, it seems to me from what I understand, soon. Which will make the task easier, because it's very difficult to convert BAM files into gedmatch (and other) compatible files... I've already done it for a nuragic sample: I had to download a VCF, so not even a bam, and the quality was a little bit more bad after conversion.

[Zoro]

I have some interest in this test to be honest but there are two things that put me off. The first is the need to become a member and pay a monthly fee every month or get a lifetime membership for $275. The second is the 100 GB of Raw Data. How would you send a 100 GB file to Davidksi to generate your G25 for example, and does he have the capacity to process a file of that size?

If you are taking it just for sending it to Davidski or gedmatch you are wasting your money because Davidski will not use the whole WGS data because his test uses data from ancient data and other 23andme people. The ancient data is only 1250k and 23andme is like 700 or 800K so he will not be using the whole WGS data.
Same think gedmatch those calculators only use maximum 180K of data

So basically your results will change maybe little bit so maybe it is worth it a little bit. I think the only tests that use wgs are Eurasiandna.com but last i heard is they didnot have time for test for individual people

[Flashball]

If you are taking it just for sending it to Davidski or gedmatch you are wasting your money because Davidski will not use the whole WGS data because his test uses data from ancient data and other 23andme people. The ancient data is only 1250k and 23andme is like 700 or 800K so he will not be using the whole WGS data.
Same think gedmatch those calculators only use maximum 180K of data

So basically your results will change maybe little bit so maybe it is worth it a little bit. I think the only tests that use wgs are Eurasiandna.com but last i heard is they didnot have time for test for individual people

Yes, my converted Bam file contains a little more than a V3 23andme but that's it, don't expect a big difference on gedmatch...

I think it is not possible to exploit this kind of data with Gedmatch and G25... I mean, yes you can but that couldn't render fidelity to the high quality of your WSG data

"I think the only tests that use wgs are Eurasiandna.com" can you expand? how can they exploit large files?

[Etelfrido]

So, how did it compare to other companies you've tried?

[kingmob]

I'll wait for your results and feedback then. I want to better understand what are the advantages and disadvantages of this company. I've been a little tired of always using the same data from 23andMe since 2017, it's time to test something different.

The advantages are that you have medical reports on your whole genome, the list is endless, this is very useful for people who are interested in diseases/conditions they may suffer from.

For geneologists, you get good Y-chr coverage and you can upload your file to something like YFULL.

For anthrotards, the advantage is that you can produce a raw-dna file that has 100% SNP coverage with all gedmatch calculators.

The disadvantages are the pricing.